Results 11 to 20 of about 42,214 (280)

Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study

Cardiovascular Diabetology, 2022
Background The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data.
Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao   +9 more
doaj   +1 more source

Between-subject and within-subject variability in measures of biochemical markers of bone turnover in cynomolgus and rhesus macaques

Bone Reports, 2021
Development of optimal bone mass during early adulthood is determined by the balance between bone formation and resorption. The utility of minimally invasive biomarkers for monitoring bone turnover balance in maturing non-human primates has received ...
Lara H. Sattgast, Adam J. Branscum, Vanessa A. Jimenez, Natali Newman, Kathleen A. Grant, Russell T. Turner, Urszula T. Iwaniec   +6 more
doaj   +1 more source

Glucose Tolerance Tests and Osteocalcin Responses in Healthy People

Frontiers in Endocrinology, 2018
Aim: Osteocalcin and undercarboxylated osteocalcin are suggested to be endocrine messengers from the bones and have been shown to stimulate insulin secretion from pancreatic β-cells.
Jakob Starup-Linde, Sidse Westberg-Rasmussen, Simon Lykkeboe, Aase Handberg, Bolette Hartmann, Jens J. Holst, Kjeld Hermansen, Peter Vestergaard, Peter Vestergaard, Søren Gregersen   +9 more
doaj   +1 more source

Serum osteocalcin levels in overweight children [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2019
Purpose Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure ...
Seok Bin Oh, Won Young Lee, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee   +4 more
doaj   +1 more source

The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2013
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c ...
Qingqing Wang, Beibei Zhang, Yulan Xu, Hongdi Xu, Nan Zhang   +4 more
doaj   +1 more source

Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function

The Journal of Clinical Investigation, 2022
Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland–derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss.
Typhanie Dumontet, Gary D. Hammer
doaj   +1 more source

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

Disease Models & Mechanisms, 2016
Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the
Laura J. Lambert, Anil K. Challa, Aidi Niu, Lihua Zhou, Janusz Tucholski, Maria S. Johnson, Tim R. Nagy, Alan W. Eberhardt, Patrick N. Estep, Robert A. Kesterson, Jayleen M. Grams   +10 more
doaj   +1 more source

Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance. [PDF]

PLoS ONE, 2013
BACKGROUND: Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood.
Martí Juanola-Falgarona, José Cándido-Fernández, Jordi Salas-Salvadó, Miguel A Martínez-González, Ramón Estruch, Miquel Fiol, Victoria Arija-Val, Mònica Bulló, PREDIMED Study Investigators   +8 more
doaj   +1 more source

Undercarboxylated osteocalcin reverts insulin resistance induced by endoplasmic reticulum stress in human umbilical vein endothelial cells

Scientific Reports, 2017
Osteocalcin has been considered to be an important regulator of energy metabolism in type 2 diabetes mellitus (T2DM). However, the mechanism underlying the involvement of uncarboxylated osteocalcin in the vascular complications of T2DM is not fully ...
Qinyue Guo, Huixia Li, Lin Xu, Shufang Wu, Hongzhi Sun, Bo Zhou   +5 more
doaj   +1 more source

Relation between osteocalcin and the energy metabolism in obesity [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Numerous findings have indicated the potential relation between the osteocalcin, the traditional parameter of bone turnover and the regulation of energy metabolism.
Nikolić Stanislava, Ćurić Nikola, Ilinčić Branislava, Stošić Zoran, Tomić-Naglić Dragana, Benc Damir   +5 more
doaj   +1 more source