Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm
Biomedicines, 2021 Unlike bolus insulin secretion mechanisms, basal insulin secretion is poorly understood. It is essential to elucidate these mechanisms in non-hyperinsulinaemia healthy persons.
Isabella D. Cooper +4 more
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Effect of Obesity and Osteocalcin on Brain Glucose Metabolism in Healthy Participants
Brain Sciences, 2023 We evaluated the effects of obesity and osteocalcin on glucose metabolism in the brain. A total of 179 healthy men were enrolled in this study. After preprocessing positron emission tomography images, including by performing coregistration, spatial ...
Seunghyeon Shin, Hyun-Yeol Nam
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Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model. [PDF]
, 2014 The clinical management of bone defects caused by trauma or nonunion fractures remains a challenge in orthopedic practice due to the poor integration and biocompatibility properties of the scaffold or implant material. In the current work, the osteogenic
Barrientos-Durán, Antonio +5 more
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Serum osteocalcin and bone mineral density in postmenopausal women
Universa Medicina, 2016 Since high bone turnover is associated with decreased bone mass, biochemical markers of bone remodeling, such as serum osteocalcin, may be used to assess osteoporosis and to predict fractures in elderly women, particulary those involving trabecular bone,
Lie T. Merijanti Susanto
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Deficits in trabecular bone microarchitecture in young women with Type 1 diabetes mellitus [PDF]
, 2015 Context: The pathophysiological mechanism of increased fractures in young adults with Type 1 Diabetes Mellitus (T1DM) is unclear. Objective: Case:control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with ...
Al-Daghri +49 more
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Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates
Frontiers in Genetics, 2021 Matrix Gla protein (Mgp) and bone Gla protein (Bgp) are vitamin-K dependent proteins that bind calcium in their γ-carboxylated versions in mammals. They are recognized as positive (Bgp) or negative (Mgp and Bgp) regulators of biomineralization in a ...
Nicolas Leurs +4 more
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The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]
, 2015 The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA +3 more
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Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones
Frontiers in Endocrinology, 2021 In addition to its structural role, the skeleton serves as an endocrine organ that controls mineral metabolism and energy homeostasis. Three major cell types in bone - osteoblasts, osteoclasts, and osteocytes – dynamically form and maintain bone and ...
Jialiang S. Wang +4 more
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Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing [PDF]
, 2010 Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Alexandra E Porter +21 more
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Jurnal Kedokteran Diponegoro, 2020 Introduction: Thalassemia is an inherited disorder that decrease the rate of globin synthesis. Multiple blood transfusions in thalassemia patients leading to complications of hemosiderosis and hemochromatosis. Iron chelator aims to remove excess iron in
Sesa Amelia +3 more
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