Results 91 to 100 of about 141,561 (326)

Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization

Scientific Reports
Several studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai, Yingxue Wang, Xinyuan Ma, Yingying Yang, Cong Deng, Mengling Sun, Chen Lin, Linkun Zhang   +7 more
doaj   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Osteoblast-derived CCN1 : A paracrine regulator of osteoclastogenesis?

, 2011
Peer ...
Aspden, R. M., Crockett, J. C., Schuetze, N., Wang, W.   +3 more
core   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Nature Communications, 2016
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function.
Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang   +33 more
doaj   +1 more source

Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3in vivo [PDF]

, 2002
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of OC seen after 1,25-(OH)2D3 administration in vivo is unclear.
A Jäger, A Kahn, B Riggs, C Dijkstra, D Fischman, D Hughes, F Solari, G Hattersley, G Hattersley, G Roodman, G Vaes, H Uy, I McLean, J Bollerslev, J Feyen, J Gram, J Merke, J Owens, J Zerwekh, JC Gallagher, JG Damoiseaux, JJ Reynolds, M Holtrop, N Athanasou, N Udagawa, P Bianco, P Geusens, P Hauschka, P McSheehy, R Beelen, R Boyce, R Felix, R Felix, R Kitazawa, RG Erben, S Manolagas, S Marks, S Mori, S Ott, S Tinkler, T Murakami, T Sminia, T Suda, T Suda, W Bourque, Y Kobayashi, Y Tanaka   +46 more
core   +4 more sources

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

LncRNA TUG1 positively regulates osteoclast differentiation by targeting v-maf musculoaponeurotic fibrosarcoma oncogene homolog B

Autoimmunity, 2020
Osteoclast differentiation-mediates bone resorption is the key biological basis of orthodontic treatment while the specific mechanism of osteoclastogenesis remains unclear.
Ya-jing Du, Qiong-qiong Yu, Xiao-fei Zheng, Su-ping Wang   +3 more
doaj   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source