Results 111 to 120 of about 100,119 (298)

Multinucleated Osteoclast

, 2002
multinucleated osteoclast ...
Lawrence, Christine
core  

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Leptin inhibits osteoclast generation

, 2002
Leptin inhibits osteoclast ...
DE Myers (14652437), GC Nicholson (14448297), Fiona Collier (17377171), JM Hodge (14447907), GR Collier (14471649), Mary Malakellis (13082913), CJ Aitken (14652431), WR Holloway (14652428), TJ Gough (14652434)   +8 more
core  

A sequential culture approach to study osteoclast differentiation from nonadherent porcine bone marrow cells

, 1998
A "sequential culture step" system was devised to study osteoclast differentiation from newborn porcine bone marrow cells. Nonadherent cells were collected from cultures of bone marrow cells, and subsequently precultured at a low cell density in low ...
Milne, J S, Robins, S P, Scheven, B A
core   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Osteoclast in Bone Marrow

, 2002
osteoclast in bone ...
Lawrence, Christine
core  

Leptin inhibits osteoclast generation.

, 2000
Leptin inhibits osteoclast ...
DE Myers (14652437), GC Nicholson (14448297), GR Collier (14471649), Mary Malakellis (13082913), CJ Aitken (14652431), WR Holloway (14652428), FM Collier (14448291), TJ Gough (14652434)   +7 more
core  

A Comparison of Osteoclast-Rich and Osteoclast-Poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation

, 2014
Osteopetrosis due to lack of acid secretion by osteoclasts is characterized by abolished bone resorption, increased osteoclast numbers, but normal or even increased bone formation.
Gudmann, Natasja Staehr, Flores Bjurström, Carmen, Henriksen, Kim, Moscatelli, Ilana,, Thomsen, Jesper S., Richter, Johan,, Hauge, Ellen-Margrethe, Moscatelli, Ilana, Bruel, Annemarie, Richter, Johan, Flores Bjurström, Carmen,, Thudium, Christian, Karsdal, Morten A., Lund University., Thudium, Christian,   +14 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.

, 2011
International audienceMultiple myeloma is characterized by the clonal expansion of malignant plasma cells (multiple myeloma cells [MMCs]), in the bone marrow.
Thierry Reme, Hose, Dirk, Jerome Moreaux, Philippe Moine, Bernard Klein, Goldschmidt, Hartmut, Guilhem Requirand, Moreaux, Jérôme, Dirk Hose, Moine, Philippe, Alboukadel Kassambara, Rème, Thierry, Requirand, Guilhem, Hartmut Goldschmidt, Kassambara, Alboukadel, Klein, Bernard   +15 more
core   +1 more source