Hells protects mitochondrial integrity via Nr2f2 suppression during osteoclast differentiation [PDF]
Cell Communication and SignalingBackground Osteoclasts are specialized bone-resorbing cells essential for skeletal homeostasis. While chromatin remodelers play critical roles in gene regulation, their specific contributions to osteoclastogenesis remain largely unexplored. In particular,
Myoung Jun Kim +7 more
doaj +2 more sources
A Novel Role of Protecadherin-7 in Regulation of Pydc3 Expression and the IFN-β Response During Osteoclast Differentiation [PDF]
CellsProtocadherin-7 (Pcdh7) is a member of the protocadherin family, a subgroup of the cadherin superfamily. We previously demonstrated that Pcdh7 functions as a signaling receptor in osteoclast differentiation.
Hyunsoo Kim +2 more
doaj +2 more sources
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
PLoS ONE, 2009 BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently ...
Guillaume Mabilleau, Afsie Sabokbar
doaj +5 more sources
CYP27A1 deficiency promoted osteoclast differentiation [PDF]
PeerJ, 2023 Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang +3 more
doaj +2 more sources
Echinococcus granulosus promotes MAPK pathway-mediated osteoclast differentiation by inhibiting Nrf2 in osseous echinococcosis [PDF]
Veterinary ResearchOsseous echinococcosis causes severe “osteolytic” changes in the bone tissue of Echinococcus granulosus (E. granulosus) infection sites by promoting the over-differentiation of osteoclasts at the site.
Yaqing Liu +7 more
doaj +2 more sources
Scientific Reports, 2023 Osteoclasts degrade bone and osteoclast differentiation has been implicated in bone destruction in rheumatoid arthritis. The dairy bacterium Propionibacterium freudenreichii MJ2 (MJ2) isolated from raw milk inhibits osteoclast differentiation and ...
Jiah Yeom +3 more
doaj +1 more source
Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. [PDF]
PLoS ONE, 2016 Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of ...
Heejin Ahn +6 more
doaj +1 more source
Vitamin Regulation of Osteoclast Differentiation
Central Asian Journal of Medical Sciences, 2020 Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu +5 more
doaj +1 more source
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
Cell & Bioscience, 2022 Background Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption.
Yufeng Zhang +10 more
doaj +1 more source
ERK5 activation is essential for osteoclast differentiation. [PDF]
PLoS ONE, 2015 The MEK/ERK pathways are critical for controlling cell proliferation and differentiation. In this study, we show that the MEK5/ERK5 pathway participates in osteoclast differentiation.
Shigeru Amano +2 more
doaj +1 more source