Results 1 to 10 of about 8,722 (259)

CYP27A1 deficiency promoted osteoclast differentiation [PDF]

PeerJ, 2023
Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin   +3 more
doaj   +4 more sources

ERK5 activation is essential for osteoclast differentiation. [PDF]

PLoS ONE, 2015
The MEK/ERK pathways are critical for controlling cell proliferation and differentiation. In this study, we show that the MEK5/ERK5 pathway participates in osteoclast differentiation.
Shigeru Amano, Yu-Tzu Chang, Yasuhisa Fukui   +2 more
doaj   +5 more sources

Vitamin Regulation of Osteoclast Differentiation [PDF]

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +3 more sources

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.

PLoS ONE, 2009
BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently ...
Guillaume Mabilleau, Afsie Sabokbar
doaj   +5 more sources

Surface proteins of Propionibacterium freudenreichii MJ2 inhibit RANKL-induced osteoclast differentiation by lipocalin-2 upregulation and lipocalin-2-mediated NFATc1 inhibition

Scientific Reports, 2023
Osteoclasts degrade bone and osteoclast differentiation has been implicated in bone destruction in rheumatoid arthritis. The dairy bacterium Propionibacterium freudenreichii MJ2 (MJ2) isolated from raw milk inhibits osteoclast differentiation and ...
Jiah Yeom, Seongho Ma, Dong Joon Yim, Young-Hee Lim   +3 more
doaj   +1 more source

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. [PDF]

PLoS ONE, 2016
Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of ...
Heejin Ahn, Kyunghee Lee, Jin Man Kim, So Hyun Kwon, Seoung Hoon Lee, Soo Young Lee, Daewon Jeong   +6 more
doaj   +1 more source

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

Cell & Bioscience, 2022
Background Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption.
Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai   +10 more
doaj   +1 more source

Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7 cells via inactivating cannabinoid receptor type 2 with AM630

Regenerative Therapy, 2020
Objective: Nuclear factor-erythroid 2-related factor 2 (Nrf2) is shown to as a negative-regulatory cause in osteoclasts differentiation. Cannabinoid receptor type 2 (CB2) is verified to regulate osteoclast differentiation, though with diversed results ...
Wan Li, Yongxin Sun
doaj   +1 more source

IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Bone Research, 2023
Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

Glycobiology in osteoclast differentiation and function

Bone Research, 2023
AbstractGlycans, either alone or in complex with glycan-binding proteins, are essential structures that can regulate cell biology by mediating protein stability or receptor dimerization under physiological and pathological conditions. Certain glycans are ligands for lectins, which are carbohydrate-specific receptors.
Shufa Yang, Ziyi He, Tong Wu, S Wang, Hui Dai   +4 more
openaire   +3 more sources