Results 11 to 20 of about 87,738 (302)

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.

PLoS ONE, 2009
BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently ...
Guillaume Mabilleau, Afsie Sabokbar
doaj   +5 more sources

IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Bone Research, 2023
Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms

Antioxidants, 2023
Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established.
Yang Yang, Zhiyuan Liu, Jinzhi Wu, Simeng Bao, Yanshuai Wang, Jiliang Li, Tao Song, Yongxin Sun, Jingbo Pi   +8 more
doaj   +1 more source

TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. [PDF]

PLoS ONE, 2012
Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Recent evidence indicates that in addition to triggering apoptosis, the TNF-related
Men-Luh Yen, Ping-Ning Hsu, Hsiu-Jung Liao, Be-Hang Lee, Hwei-Fang Tsai   +4 more
doaj   +1 more source

Regulation of TNF-Induced Osteoclast Differentiation [PDF]

Cells, 2021
Increased osteoclast (OC) differentiation and activity is the critical event that results in bone loss and joint destruction in common pathological bone conditions, such as osteoporosis and rheumatoid arthritis (RA). RANKL and its decoy receptor, osteoprotegerin (OPG), control OC differentiation and activity.
Zhenqiang Yao, Stephen J. Getting, Ian C. Locke   +2 more
openaire   +3 more sources

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts

Frontiers in Immunology, 2022
Osteoclasts are polykaryons formed by cell–cell fusion of highly motile progenitors of the myeloid lineage. Osteoclast activity can preserve skeletal strength and bone homeostasis.
Bettina Groetsch, Elisabeth Schachtschabel, Philipp Tripal, Benjamin Schmid, Ana-Suncana Smith, Georg Schett, Aline Bozec   +6 more
doaj   +1 more source

Osteoclast Differentiation [PDF]

Critical Reviews in Oral Biology & Medicine, 1991
The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
openaire   +2 more sources

Osteoclast Differentiation Requires Ascorbic Acid [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Osteoclast differentiation assays are usually conducted in alpha minimal essential medium (α-MEM). We reasoned that determining which components of this media are critical for osteoclast differentiation might provide insight into the mechanisms that regulate osteoclast differentiation.
A A, Ragab, S A, Lavish, M A, Banks, V M, Goldberg, E M, Greenfield   +4 more
openaire   +2 more sources

The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats

Scientific Reports, 2023
When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that ...
Shohei Shigemi, Tadasu Sato, Mayuri Sakamoto, Takehiro Yajima, Takahiro Honda, Hiroka Tsumaki, Toru Deguchi, Hiroyuki Ichikawa, Tomohiro Fukunaga, Itaru Mizoguchi   +9 more
doaj   +1 more source

lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis

Acta Biochimica et Biophysica Sinica, 2023
Long noncoding RNAs (lncRNAs) are important regulators of bone metabolism. In this study, lncRNA microarray analysis was used to identify differentially expressed lncRNAs in differentiated osteoclasts.
Zhang Jian, Zhang Lingyan, Yao Gang, Zhao Hai, Qiao Penghai, Wu Shuguang   +5 more
doaj   +1 more source