Results 11 to 20 of about 8,722 (259)
Osteogenic Differentiation of Human Gingival Fibroblasts Inhibits Osteoclast Formation [PDF]
CellsGingival fibroblasts (GFs) can differentiate into osteoblast-like cells and induce osteoclast precursors to differentiate into osteoclasts. As it is unclear whether these two processes influence each other, we investigated how osteogenic differentiation ...
Merve Ceylan +7 more
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Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation [PDF]
Cell Communication and SignalingBone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL).
Aaron Babendreyer +8 more
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Regulation of TNF-Induced Osteoclast Differentiation. [PDF]
, 2021 Increased osteoclast (OC) differentiation and activity is the critical event that results in bone loss and joint destruction in common pathological bone conditions, such as osteoporosis and rheumatoid arthritis (RA).
Yao, Zhenqiang +2 more
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TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. [PDF]
PLoS ONE, 2012 Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Recent evidence indicates that in addition to triggering apoptosis, the TNF-related
Men-Luh Yen +4 more
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Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms
Antioxidants, 2023 Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established.
Yang Yang +8 more
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Frontiers in Immunology, 2022 Osteoclasts are polykaryons formed by cell–cell fusion of highly motile progenitors of the myeloid lineage. Osteoclast activity can preserve skeletal strength and bone homeostasis.
Bettina Groetsch +6 more
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Osteoclast Differentiation [PDF]
Critical Reviews in Oral Biology & Medicine, 1991 The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
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Scientific Reports, 2023 When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that ...
Shohei Shigemi +9 more
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lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis
Acta Biochimica et Biophysica Sinica, 2023 Long noncoding RNAs (lncRNAs) are important regulators of bone metabolism. In this study, lncRNA microarray analysis was used to identify differentially expressed lncRNAs in differentiated osteoclasts.
Zhang Jian +5 more
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Signaling Pathways in Osteoclast Differentiation [PDF]
Chonnam Medical Journal, 2016 Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). M-CSF and RANKL bind to their respective
Kim, Jung Ha, Kim, Nacksung
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