The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]
, 2013 Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Stefanie Herkt +11 more
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Differentiation and function of osteoclasts
The Keio Journal of Medicine, 2003 Osteoclasts, which are responsible for bone resorption, are rare cells with only 2-3 cells seen per 1 mm3 of bone. However, the loss of function in osteoclasts, problems with their differentiation and decrease in their number lead to bone osteosclerosis/osteopetrosis. On the other hand, an increase in their number or function induces bone osteoporosis,
Miyamoto, Takeshi, Suda, Toshio
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Tnf-Related Apoptosis-Inducing Ligand (Trail) Induces Osteoclast Differentiation from Monocyte/Macrophage Lineage Precursor Cells [PDF]
, 2011 Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Many of the proinflammatory cytokines and growth factors implicated in inflammatory
YEN, MEN-LUH;TSAI, HWEI-FANG;WU, YI-YING;HWA, HSIAO-LIN;LEE, BE-HAN;HSU, PING-NING +1 more
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Ribosome Inactivating Protein B-Chain Induces Osteoclast Differentiation from Monocyte/Macrophage Lineage Precursor Cells [PDF]
, 2012 Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain.
王淵明;陸自利;許秉寧;湯智昕;劉國慶;高榮達;曾志正 +1 more
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Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. [PDF]
PLoS ONE, 2017 Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoting breast cancer growth and progression. While the autocrine effects of FGFR activation in tumor cells have been extensively studied, little is known about the ...
Kelly Aukes +8 more
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Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]
, 2013 Peer ...
Thompson, K. +3 more
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Life, 2022 (1) Background: Osteoporosis is a disease in which bones are weakened and fractured easily because of various factors. It is mainly observed in elderly and postmenopausal women, and it continues to carry high economic costs in aging societies.
Yongjin Lee +5 more
doaj +1 more source
Regulation of NFATc1 in Osteoclast Differentiation [PDF]
Journal of Bone Metabolism, 2014 Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL).
Kim, Jung Ha, Kim, Nacksung
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Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation [PDF]
, 2015 Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammatory ...
Fukuma, Yutaka +15 more
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A novel assay for analysis of the regulation of the function of human osteoclasts. [PDF]
, 2006 BACKGROUND: Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo.
Shiroo Masahiro +17 more
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