Life, 2022 (1) Background: Osteoporosis is a disease in which bones are weakened and fractured easily because of various factors. It is mainly observed in elderly and postmenopausal women, and it continues to carry high economic costs in aging societies.
Yongjin Lee +5 more
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The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]
, 2013 Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Stefanie Herkt +17 more
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Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation [PDF]
, 2015 Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammatory ...
Fukuma, Yutaka +15 more
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Involvement of Noncoding RNAs in the Differentiation of Osteoclasts
Stem Cells International, 2020 As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism.
Yi Zhao +3 more
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Hippo signaling protein MST1 regulates osteoclast differentiation by interacting with integrin linked kinase (ILK) and modulating actin structures [PDF]
Archives of Biological Sciences, 2016 Hippo signaling is implicated in balancing cell proliferation, differentiation and death in multiple organs. However, its role in specific bone cell types such as osteoclasts, and its significance in maintaining overall bone tissue homeostasis ...
Huang Xiao-Han, Su Pan, Li Wu-Yin
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Cells, 2021 Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells.
So-Yeon Kim +4 more
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Cells, 2023 Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup of the cadherin superfamily. Pcdh7 has been revealed to control osteoclast differentiation by regulating Rho-family small GTPases, RhoA and Rac1, through its intracellular
Hyunsoo Kim +2 more
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Sodium-Dependent Phosphate Transporters in Osteoclast Differentiation and Function [PDF]
, 2015 Osteoclasts are multinucleated bone degrading cells. Phosphate is an important constituent of mineralized bone and released in significant quantities during bone resorption.
Biber, Jürg +52 more
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Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation [PDF]
, 2016 Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation.
和田, 政裕 +17 more
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Precision-Engineered Nanotopographical Surfaces to Control Osteoclast Differentiation
, 2016 We have developed precision-engineered strontium eluting nanopatterned surfaces. Nanotopography has been shown to increase osteoblast differentiation, and strontium is an element similar to calcium, which has been proven to increase new bone formation ...
Tsimbouri, P.M. +5 more
core +6 more sources