Results 31 to 40 of about 919,707 (247)

Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. [PDF]

PLoS ONE, 2015
An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of LCPUFAs on human osteoclast formation
Abe E Kasonga, Vishwa Deepak, Marlena C Kruger, Magdalena Coetzee   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ribosome Inactivating Protein B-Chain Induces Osteoclast Differentiation from Monocyte/Macrophage Lineage Precursor Cells

, 2012
Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain.
王淵明;陸自利;許秉寧;湯智昕;劉國慶;高榮達;曾志正, WANG, YUAN-MIN;LU, TZU-LI;HSU, PING-NING;TANG, CHIH-HSIN;LIU, KUO-CHING;KAO, JUNG-TA;TZEN, JASON T.C.;WU, YI-YING   +1 more
core   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Tnf-Related Apoptosis-Inducing Ligand (Trail) Induces Osteoclast Differentiation from Monocyte/Macrophage Lineage Precursor Cells

, 2011
Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Many of the proinflammatory cytokines and growth factors implicated in inflammatory
YEN, MEN-LUH;TSAI, HWEI-FANG;WU, YI-YING;HWA, HSIAO-LIN;LEE, BE-HAN;HSU, PING-NING, 嚴孟祿;蔡慧芳;吳怡瑩;華筱玲;李碧涵;許秉寧   +1 more
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral Science
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step.
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu   +9 more
doaj   +1 more source

Extracellular Vesicles Derived From Murine Cementoblasts Possess the Potential to Increase Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis

Frontiers in Physiology, 2022
Cementum resorption, unlike bone resorption, is clinically known to occur only with limited pathological stimuli, such as trauma, orthodontic forces, and large apical periodontitis; however, the molecular mechanisms that control osteoclast formation on ...
Rei Sato, Kentaro Maruyama, Eiji Nemoto, Yukihiko Sakisaka, Shigeki Suzuki, Jiajun Li, Kento Numazaki, Hiroyuki Tada, Satoru Yamada   +8 more
doaj   +1 more source

BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells [PDF]

, 2013
Gene expressionis controlled by epigenetic mechanisms including histone methylation. Osteoclasts are bone-resorptive cells that differentiate from hematopoietic-precursor cells by receptor activator of nuclear factor-KB ligand (RANKL) stimulation ...
Tsuda, Hiromasa, Kuniyasu Ochiai, Imai, Kenichi, Zhao, Ning, Ochiai, Kuniyasu, Hiromasa Tsuda, Kenichi Imai, Ning Zhao, Pishan Yang, Naoto Suzuki, Yang, Pishan, Suzuki, Naoto   +11 more
core   +1 more source