Results 31 to 40 of about 8,722 (259)

Involvement of Noncoding RNAs in the Differentiation of Osteoclasts

Stem Cells International, 2020
As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism.
Yi Zhao, Lingfei Jia, Yunfei Zheng, Weiran Li   +3 more
doaj   +1 more source

Sodium-Dependent Phosphate Transporters in Osteoclast Differentiation and Function [PDF]

, 2015
Osteoclasts are multinucleated bone degrading cells. Phosphate is an important constituent of mineralized bone and released in significant quantities during bone resorption.
Biber, Jürg, Bonny, Olivier, Wagner, Carsten A, Hernando, N., Wagner, C.A., Moor, M., Moor, Matthias, Wagner, Carsten A., Fuster, D.G., Olivier Bonny, Nati Hernando, Matthias Moor, Dolder, Silvia, Giuseppe Albano, Hofstetter, Willy, Albano, G., Albano, Giuseppe, Jürg Biber, Hofstetter, Wilhelm, Daniel G Fuster, Silvia Dolder, Fuster, Daniel G, Carsten A Wagner, Siegrist, Mark, Willy Hofstetter, Dolder, S., Siegrist, M., Hofstetter, W., Biber, J., Bonny, O., Hernando, Nati, Mark Siegrist, Fuster, Daniel Guido   +32 more
core   +1 more source

Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway

Cells, 2021
Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells.
So-Yeon Kim, Younseo Oh, Sungsin Jo, Jong-Dae Ji, Tae-Hwan Kim   +4 more
doaj   +1 more source

Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss [PDF]

, 2016
Increased osteoclast (OC) bone resorption and/or decreased osteoblast (OB) bone formation contribute to bone loss in osteoporosis and rheumatoid arthritis (RA).
Yao, Z.
core   +1 more source

LncRNA TUG1 positively regulates osteoclast differentiation by targeting v-maf musculoaponeurotic fibrosarcoma oncogene homolog B

Autoimmunity, 2020
Osteoclast differentiation-mediates bone resorption is the key biological basis of orthodontic treatment while the specific mechanism of osteoclastogenesis remains unclear.
Ya-jing Du, Qiong-qiong Yu, Xiao-fei Zheng, Su-ping Wang   +3 more
doaj   +1 more source

Hippo signaling protein MST1 regulates osteoclast differentiation by interacting with integrin linked kinase (ILK) and modulating actin structures [PDF]

Archives of Biological Sciences, 2016
Hippo signaling is implicated in balancing cell proliferation, differentiation and death in multiple organs. However, its role in specific bone cell types such as osteoclasts, and its significance in maintaining overall bone tissue homeostasis ...
Huang Xiao-Han, Su Pan, Li Wu-Yin
doaj   +1 more source

The role of osteoblast cells in the pathogenesis of unicameral bone cysts [PDF]

, 2012
PurposeThe pathogenesis of unicameral bone cysts (UBCs) remains largely unknown. Osteoclasts have been implicated, but the role of osteoblastic cells has, to date, not been explored.
Tayton, Edward R, Fowler, Darren J., Edward D. Gent, Richard O. C. Oreffo, Smith, James O., Oreffo, Richard O.C., Caroline J. Edwards, Edward R. Tayton, James O. Smith, Aarvold, Alexander, Darren J. Fowler, Gent, Edward D., Edwards, Caroline J., Alexander Aarvold   +13 more
core   +1 more source

Osteoclast-Responsive, Injectable Bone of Bisphosphonated-Nanocellulose that Regulates Osteoclast/Osteoblast Activity for Bone Regeneration [PDF]

, 2019
An injectable bone may serve as a minimally invasive therapy for large orthopedic defects and osteoporosis and an alternative to allografting and surgical treatment.
Akihiro Nishiguchi (1532491), Tetsushi Taguchi (1495435)   +1 more
core   +1 more source

PP2A-Mediated GSK3β Dephosphorylation Is Required for Protocadherin-7-Dependent Regulation of Small GTPase RhoA in Osteoclasts

Cells, 2023
Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup of the cadherin superfamily. Pcdh7 has been revealed to control osteoclast differentiation by regulating Rho-family small GTPases, RhoA and Rac1, through its intracellular
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

Osteoclast differentiation in rheumatoid arthritis

Immunological Medicine, 2023
Osteoclasts, derived from the monocyte/macrophage line of bone marrow hematopoietic stem cell progenitors, are the sole bone-resorbing cells of the body. Conventional osteoclast differentiation requires macrophage colony-stimulating factor and receptor activator of nuclear factor kappa-B ligand (RANKL) signaling.
openaire   +3 more sources