Results 51 to 60 of about 8,722 (259)

MDP/NOD2はRAW264.7細胞におけるRANKL誘導破骨細胞分化を促進する [PDF]

大阪歯科大学Osaka Dental University博士（歯学）Objective: Receptor activator of nuclear factor-κB ligand (RANKL) is intimately involved in regulating bone remodeling during osteoclast differentiation and promotion of osteoclast function. Upon binding to its receptor,
スギモト, ワカナ, 杉本, 和香菜, Sugimoto, Wakana   +2 more
core   +1 more source

miRNA-340 inhibits osteoclast differentiation via repression of MITF [PDF]

, 2017
Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in ...
Hongying Zhao, Jun Zhang, Haiyu Shao, Mengran Jin, Jinping Chen, Jianwen Liu, Yazeng Huang   +6 more
core   +1 more source

CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral Science
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step.
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu   +9 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Synovial macrophage-osteoclast differentiation in inflammatory arthritis. [PDF]

, 2002
BACKGROUND: Pathological bone resorption (marginal erosions and juxta-articular osteoporosis) by osteoclasts commonly occurs in rheumatoid arthritis (RA).
Athanasou, NA, Danks, L, Sabokbar, A, Sabokbar, Afsaneh, Gundle, R, Athanasou, Nicholas   +5 more
core   +1 more source

Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization

Scientific Reports
Several studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai, Yingxue Wang, Xinyuan Ma, Yingying Yang, Cong Deng, Mengling Sun, Chen Lin, Linkun Zhang   +7 more
doaj   +1 more source

A Novel Role of Protecadherin-7 in Regulation of Pydc3 Expression and the IFN-β Response During Osteoclast Differentiation

Cells
Protocadherin-7 (Pcdh7) is a member of the protocadherin family, a subgroup of the cadherin superfamily. We previously demonstrated that Pcdh7 functions as a signaling receptor in osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NFκB and Interferon signaling; implications for Paget’s disease [PDF]

, 2015
Paget’s disease of bone (PDB) is a common disease characterized by osteoclast activation that leads to various skeletal complications. Susceptibility to PDB is mediated by a common variant at the optineurin (OPTN) locus, which is associated with reduced ...
Ralston, Stuart H., Wani, Sachin E., Hurd, Toby, Azfer, Asim, Obaid, Rami, Rami Obaid, Sachin E. Wani, Ruth Jones, Albagha, Omar M. E., Toby Hurd, Albagha, Omar M.E., Obaid, Rami Abdulhadi Abdulmajeed, Philip Cohen, Omar M.E. Albagha, Cohen, Philip; id_orcid, Cohen, Philip, Asim Azfer, Stuart H. Ralston, Jones, Ruth   +18 more
core   +1 more source

Extracellular Vesicles Derived From Murine Cementoblasts Possess the Potential to Increase Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis

Frontiers in Physiology, 2022
Cementum resorption, unlike bone resorption, is clinically known to occur only with limited pathological stimuli, such as trauma, orthodontic forces, and large apical periodontitis; however, the molecular mechanisms that control osteoclast formation on ...
Rei Sato, Kentaro Maruyama, Eiji Nemoto, Yukihiko Sakisaka, Shigeki Suzuki, Jiajun Li, Kento Numazaki, Hiroyuki Tada, Satoru Yamada   +8 more
doaj   +1 more source