Results 61 to 70 of about 8,722 (259)

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis [PDF]

, 2009
Kazuo Yudoh1, Rie Karasawa1, Kayo Masuko2, Tomohiro Kato21Department of Frontier Medicine, 2Department of Biochemistry, Institute of Medical Science, St.
Kayo Masuko, et al, Kazuo Yudoh, Rie Karasawa   +3 more
core  

Serum amyloid a inhibits osteoclast differentiation to maintain macrophage function [PDF]

, 2016
Serum amyloid A is an acute phase protein that is elevated under inflammatory conditions. Additionally, the serum levels of serum amyloid A are associated with the progression of inflammatory arthritis; thus, serum amyloid A might be involved in the ...
O J Park, S H Han, S S Kang, Jihyun Yang, J Kim, C H Yun   +5 more
core   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Release from optimal compressive force suppresses osteoclast differentiation [PDF]

, 2016
Bone remodeling is an important factor in orthodontic tooth movement. During orthodontic treatment, osteoclasts are subjected to various mechanical stimuli, and this promotes or inhibits osteoclast differentiation and fusion.
Suzuki, Kuniaki, Hayakawa, Takako, Yoshimura, Yoshitaka, Fukushima, Kumu, Iida, Junichiro, Kikuiri, Takashi, Hasegawa, Tomokazu, Ikeda, Masaaki, Matsuno, Mino, Minamikawa, Hajime   +9 more
core   +1 more source

The Role of Follistatin-like 1 in the Cross-Talk Among Osteoclastogenesis, Bone Marrow Stromal Cell Migration, and Osteoblastogenesis In Vitro

Biomedicines
Background: Bone remodeling depends on the dynamic balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Follistatin-like 1 (FSTL1) has been reported as an osteoclast-secreted protein that inhibits osteoclast ...
Yongxu Piao, Xiangguo Che, Xian Jin, Dong-Kyo Lee, Min Park, Eun-Jung Heo, Jinyoung Oh, Seong-Gon Kim, Dae-Chul Cho, Hyun-Ju Kim, Je-Yong Choi   +10 more
doaj   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Regulation of Osteoclast Differentiation by Myosin X [PDF]

, 2017
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Eric D. Jensen, Rajaram Gopalakrishnan, Amy Tasca, Kristina Astleford, Ari Lederman, Beth S. Lee, Kim C. Mansky   +6 more
core   +1 more source

Polyphenolic Compounds Inhibit Osteoclast Differentiation While Reducing Autophagy through Limiting ROS and the Mitochondrial Membrane Potential

Biomolecules, 2022
Polyphenolic compounds are a diverse group of natural compounds that interact with various cellular proteins responsible for cell survival, differentiation, and apoptosis. However, it is yet to be established how these compounds interact in myeloid cells
Dipranjan Laha, Jaganmay Sarkar, Jyotirindra Maity, Asmita Pramanik, Md Sariful Islam Howlader, Derek Barthels, Hiranmoy Das   +6 more
doaj   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source