Results 1 to 10 of about 21,677 (225)
NFATc1 controls the cytotoxicity of CD8+ T cells [PDF]
Nature Communications, 2017 NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal ...
Martin Väth +2 more
exaly +9 more sources
NFATC1 and NFATC2 expression patterns in human osteochondromas
Heliyon, 2023 Background: Our previous study in genetic mouse models found that NFATc1 and NFATc2 suppress osteochondroma formation from entheseal progenitors. However, it remains unclear whether NFAT signaling is also involved in human osteochondromagenesis.
Yuanyuan Wang +3 more
doaj +3 more sources
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]
OncogenesisThe pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang +8 more
doaj +2 more sources
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development [PDF]
Nature Communications, 2016 NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in ...
Stefan Klein-Hessling +12 more
doaj +12 more sources
Involvement of PU.1 in NFATc1 promoter function in osteoclast development
Allergology International, 2015 Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficient ...
Takuya Yashiro +2 more
exaly +3 more sources
Bone Reports, 2021 The transcription factor NFATc1 and its binding partner AP-1 (a complex containing c-fos and c-Jun) play a central role in osteoclast differentiation. NFATc1 and AP-1 promote the expression of target genes such as Acp5, Ctsk and also auto-regulate NFATc1
Kazuma Yasuda +4 more
doaj +1 more source
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
Cells, 2021 Background: The Nuclear Factor of Activated T-cells 1 (NFATc1) transcription factor and the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) significantly contribute to the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC).
Shilpa Patil +11 more
doaj +1 more source
Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation
Scientific Reports, 2023 During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner.
Yasuhiro Omata +4 more
doaj +1 more source
eLife, 2023 The origin and differentiation mechanism of articular chondrocytes remain poorly understood. Broadly, the difference in developmental mechanisms of articular and growth-plate cartilage is still less elucidated. Here, we identified that the nuclear factor
Fan Zhang +6 more
doaj +1 more source
The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]
, 2013 Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Courtial, Nadine +5 more
core +10 more sources