Results 1 to 10 of about 13,264 (178)
DYRK1A activates NFATC1 to increase glioblastoma migration [PDF]
Cancer Medicine, 2021 Glioblastoma (GBM) is the most aggressive glioma, and is prone to develop resistance to chemotherapy and radiotherapy; hence, patients with glioblastoma have a high recurrence rate and a low 1‐year survival rate.
Heng Liu, Juan Zhao, Xiulian Sun
exaly +4 more sources
Architecture and Expression of the Nfatc1 Gene in Lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Amiya K Patra +2 more
exaly +6 more sources
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
Cells, 2021 Background: The Nuclear Factor of Activated T-cells 1 (NFATc1) transcription factor and the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) significantly contribute to the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC).
Shilpa Patil +2 more
exaly +3 more sources
NFATC1 and NFATC2 expression patterns in human osteochondromas
Heliyon, 2023 Background: Our previous study in genetic mouse models found that NFATc1 and NFATc2 suppress osteochondroma formation from entheseal progenitors. However, it remains unclear whether NFAT signaling is also involved in human osteochondromagenesis.
Yuanyuan Wang +3 more
doaj +3 more sources
Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ [PDF]
FEBS Open Bio, 2018 Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because
Kyeong‐Lok Park +4 more
doaj +3 more sources
Cells, 2019 NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood.
Roberta Russo +2 more
exaly +3 more sources
Involvement of PU.1 in NFATc1 promoter function in osteoclast development
Allergology International, 2015 Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficient ...
Takuya Yashiro +2 more
exaly +3 more sources
NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs
Frontiers in Immunology, 2022 CD4+CXCR5+Foxp3+ T-follicular regulatory (TFR) cells control the germinal center responses. Like T-follicular helper cells, they express high levels of Nuclear Factor of Activated T-cells c1, predominantly its short isoform NFATc1/αA.
Martin Vaeth, Yin Xiao, Lena Dietz
exaly +3 more sources
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]
OncogenesisThe pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang +8 more
doaj +2 more sources
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes [PDF]
Cell Communication and Signaling, 2012 In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling Edgar +5 more
doaj +3 more sources