Results 1 to 10 of about 13,969 (112)
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
Cells, 2021 Background: The Nuclear Factor of Activated T-cells 1 (NFATc1) transcription factor and the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) significantly contribute to the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC).
Shilpa Patil +2 more
exaly +3 more sources
Cells, 2019 NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood.
Roberta Russo +2 more
exaly +3 more sources
Involvement of PU.1 in NFATc1 Promoter Function in Osteoclast Development
Allergology International, 2015 Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficient ...
Nobuhiro Nakano +2 more
exaly +3 more sources
DYRK1A Activates NFATC1 to Increase Glioblastoma Migration
Cancer Medicine, 2021 Glioblastoma (GBM) is the most aggressive glioma, and is prone to develop resistance to chemotherapy and radiotherapy; hence, patients with glioblastoma have a high recurrence rate and a low 1‐year survival rate.
Heng Liu, Xiulian Sun, Wenming Jia
exaly +2 more sources
NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs
Frontiers in Immunology, 2022 CD4+CXCR5+Foxp3+ T-follicular regulatory (TFR) cells control the germinal center responses. Like T-follicular helper cells, they express high levels of Nuclear Factor of Activated T-cells c1, predominantly its short isoform NFATc1/αA.
Andreas Rosenwald +2 more
exaly +3 more sources
Targeting TARDBP to Restore Colonic Barrier Integrity in Ulcerative Colitis via NFATC1 mRNA Destabilization [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by limited understanding of post-transcriptional mechanisms governing intestinal barrier integrity.
Yin Jiang +7 more
doaj +2 more sources
Scientific ReportsThe Nuclear Factor of Activated T-cells cytoplasmic 1 (NFATc1) is identified to be an oncogene in several human cancers. However, its specific role in HCC progression and the relevant mechanisms remain unclear.
Junping Shi, Congrui Zhang
exaly +2 more sources
Two Faces of NFAT Transcription Factors in Lymphocytes—A Personal Account [PDF]
BiomoleculesThe two NFAT transcription factors NFATc1 and NFATc2 are the most prominent Ca++-dependent TFs in the nuclei of activated peripheral lymphocytes. They control the activity of thousands of genes during immune responses.
Edgar Serfling
doaj +2 more sources
Bone Reports, 2021 The transcription factor NFATc1 and its binding partner AP-1 (a complex containing c-fos and c-Jun) play a central role in osteoclast differentiation. NFATc1 and AP-1 promote the expression of target genes such as Acp5, Ctsk and also auto-regulate NFATc1
Kazuma Yasuda +4 more
doaj +1 more source
Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation
Scientific Reports, 2023 During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner.
Yasuhiro Omata +4 more
doaj +1 more source