Architecture and Expression of the Nfatc1 Gene in Lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Khalid Muhammad +2 more
exaly +11 more sources
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer [PDF]
Cells, 2021 Background: The Nuclear Factor of Activated T-cells 1 (NFATc1) transcription factor and the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) significantly contribute to the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC).
Shilpa Patil +2 more
exaly +6 more sources
DYRK1A activates NFATC1 to increase glioblastoma migration [PDF]
Cancer Medicine, 2021 Glioblastoma (GBM) is the most aggressive glioma, and is prone to develop resistance to chemotherapy and radiotherapy; hence, patients with glioblastoma have a high recurrence rate and a low 1‐year survival rate.
Heng Liu, Xiulian Sun
exaly +4 more sources
Gene Expression Profiling of NFATc1-Knockdown in RAW 264.7 Cells: An Alternative Pathway for Macrophage Differentiation [PDF]
Cells, 2019 NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood.
Roberta Russo +2 more
exaly +4 more sources
NFATc1 phosphorylation by DYRK1A increases its protein stability. [PDF]
PLoS ONE, 2017 NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation.
Heng Liu +6 more
doaj +5 more sources
Mitf regulates osteoclastogenesis by modulating NFATc1 activity [PDF]
Experimental Cell Research, 2014 Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible that the two factors work together to promote osteoclastogenesis.
Ssu-Yi Lu, Mengtao Li, Yi-Ling Lin
openaire +7 more sources
NFATc1 controls the cytotoxicity of CD8+ T cells [PDF]
Nature Communications, 2017 AbstractCytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 −/− cytotoxic T lymphocytes showed a defective cytoskeleton organization and ...
Stefan Klein-Hessling +20 more
openaire +7 more sources
NFATC1 and NFATC2 expression patterns in human osteochondromas
Heliyon, 2023 Background: Our previous study in genetic mouse models found that NFATc1 and NFATc2 suppress osteochondroma formation from entheseal progenitors. However, it remains unclear whether NFAT signaling is also involved in human osteochondromagenesis.
Yuanyuan Wang +3 more
doaj +3 more sources
Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ [PDF]
FEBS Open Bio, 2018 Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because
Kyeong‐Lok Park +4 more
doaj +3 more sources
Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation [PDF]
Scientific Reports, 2023 During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner.
Yasuhiro Omata +4 more
doaj +2 more sources