Results 11 to 20 of about 15,571 (214)
Involvement of PU.1 in NFATc1 promoter function in osteoclast development
Allergology International, 2015 Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficient ...
Nobuhiro Nakano +2 more
exaly +3 more sources
NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs
Frontiers in Immunology, 2022 CD4+CXCR5+Foxp3+ T-follicular regulatory (TFR) cells control the germinal center responses. Like T-follicular helper cells, they express high levels of Nuclear Factor of Activated T-cells c1, predominantly its short isoform NFATc1/αA.
Andreas Rosenwald +2 more
exaly +3 more sources
Extracellular C1qbp inhibits myogenesis by suppressing NFATc1 [PDF]
Scientific ReportsAbstractAging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limited skeletal muscles.
Jin-Man Kim +8 more
openaire +4 more sources
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes [PDF]
Cell Communication and Signaling, 2012 In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling Edgar +5 more
doaj +3 more sources
NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression [PDF]
OncogenesisThe pentose phosphate pathway (PPP) supplies abundant reducing equivalents and biosynthetic precursors to support the rapid proliferation of tumor cells. An increased PPP flux is a hallmark of metabolic reprogramming in tumors. Although nuclear factor of
Suyang Zhang +8 more
doaj +2 more sources
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells [PDF]
Cell, 2008 Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP ...
Horsley, Valerie +4 more
openaire +4 more sources
Scientific ReportsThe Nuclear Factor of Activated T-cells cytoplasmic 1 (NFATc1) is identified to be an oncogene in several human cancers. However, its specific role in HCC progression and the relevant mechanisms remain unclear.
Liyuan Huang +2 more
exaly +2 more sources
NFATc1 as a Therapeutic Target in Burkitt’s Lymphoma [PDF]
, 2015 Das Burkitt Lymphom (BL) ist ein sehr aggressives, aus dem Keimzentrum entsprungenes, B Zell Lymphom. Es tritt meisten in Kindern aus Äquatorialafrika auf, welche sowohl das EB-Virus als auch den Malariaerreger in sich tragen. Neben dieser endemischen Form gibt es auch eine sporadische und eine Immundefizienz-assozierte Form.
Fender, Hendrik Eike
openaire +2 more sources
NFATc1 deficiency in B cells ameliorates atopic dermatitis
Scientific ReportsAtopic dermatitis (AD) is a common skin allergy, affecting large population worldwide. Currently, there is no cure for AD. NFATc1, a transcription factor, operates through a calcium-dependent calcineurin/calmodulin pathway to regulate target genes and is
Hidaya Abdul Kader +11 more
doaj +3 more sources
Bone Reports, 2021 The transcription factor NFATc1 and its binding partner AP-1 (a complex containing c-fos and c-Jun) play a central role in osteoclast differentiation. NFATc1 and AP-1 promote the expression of target genes such as Acp5, Ctsk and also auto-regulate NFATc1
Kazuma Yasuda +4 more
doaj +1 more source