Results 11 to 20 of about 21,677 (225)
Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ [PDF]
FEBS Open Bio, 2018 Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because
Kyeong‐Lok Park +4 more
doaj +3 more sources
DYRK1A activates NFATC1 to increase glioblastoma migration [PDF]
Cancer Medicine, 2021 Glioblastoma (GBM) is the most aggressive glioma, and is prone to develop resistance to chemotherapy and radiotherapy; hence, patients with glioblastoma have a high recurrence rate and a low 1‐year survival rate.
Heng Liu +6 more
doaj +3 more sources
NFATc1 phosphorylation by DYRK1A increases its protein stability.
PLoS ONE, 2017 NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation.
Heng Liu +6 more
doaj +4 more sources
Architecture and expression of the Nfatc1 gene in lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Ronald eRudolf +7 more
doaj +4 more sources
Regulation of NFATc1 in Osteoclast Differentiation [PDF]
Journal of Bone Metabolism, 2014 Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL).
Kim, Jung Ha, Kim, Nacksung
openaire +2 more sources
NFATc1 and NFATc2 repress spontaneous osteoarthritis [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Currently, little is understood about how the transcriptional regulation of cartilage breakdown contributes to pathogenesis of osteoarthritis (OA). Here, we report that, within cartilage, the transcription factor Nuclear factor of activated T cells c1 (NFATc1) displays selective expression in superficial articular ...
Matthew B, Greenblatt +6 more
openaire +2 more sources
Mitf regulates osteoclastogenesis by modulating NFATc1 activity [PDF]
Experimental Cell Research, 2014 Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible that the two factors work together to promote osteoclastogenesis.
Ssu-Yi Lu, Mengtao Li, Yi-Ling Lin
openaire +4 more sources
Frontiers in Pharmacology, 2021 Integrity of the skeleton is sustained through the balanced activities of osteoblasts and osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts activation commonly seen in osteoporosis.
Delong Chen +11 more
doaj +1 more source
Dental Journal, 2019 Background: Enterococcus faecalis (E. faecalis) is the most common bacteria species in persistent endodontic infection of teeth undergoing root canal treatment at a prevalence of 38%.
Nirawati Pribadi +5 more
doaj +1 more source
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]
, 2015 The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya +10 more
core +2 more sources