Architecture and expression of the Nfatc1 gene in lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Ronald eRudolf +7 more
doaj +7 more sources
NFATc1 phosphorylation by DYRK1A increases its protein stability.
PLoS ONE, 2017 NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation.
Heng Liu +6 more
doaj +5 more sources
Mitf regulates osteoclastogenesis by modulating NFATc1 activity [PDF]
Experimental Cell Research, 2014 Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible ...
Li, Mengtao, Lu, Ssu-Yi, Lin, Yi-Ling
core +6 more sources
NFATC1 and NFATC2 expression patterns in human osteochondromas
Heliyon, 2023 Background: Our previous study in genetic mouse models found that NFATc1 and NFATc2 suppress osteochondroma formation from entheseal progenitors. However, it remains unclear whether NFAT signaling is also involved in human osteochondromagenesis.
Yuanyuan Wang +3 more
doaj +3 more sources
Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ [PDF]
FEBS Open Bio, 2018 Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because
Kyeong‐Lok Park +4 more
doaj +3 more sources
NFATc1 controls the cytotoxicity of CD8+ T cells [PDF]
Nature Communications, 2017 Cytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 −/−
Ronald Rudolf +41 more
core +6 more sources
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes [PDF]
Cell Communication and Signaling, 2012 In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling Edgar +5 more
doaj +3 more sources
Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
Scientific ReportsAging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limited skeletal ...
Jin-Man Kim +8 more
core +4 more sources
Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation. [PDF]
Adv Sci (Weinh)Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Lu J +5 more
europepmc +2 more sources
NFATc1 deficiency in B cells ameliorates atopic dermatitis
Scientific ReportsAtopic dermatitis (AD) is a common skin allergy, affecting large population worldwide. Currently, there is no cure for AD. NFATc1, a transcription factor, operates through a calcium-dependent calcineurin/calmodulin pathway to regulate target genes and is
Hidaya Abdul Kader +11 more
doaj +3 more sources