Results 21 to 30 of about 16,913 (200)

NFATc1 is Suppressed in Tumor Microenvironment of Hodgkin Lymphoma [PDF]

Asian Pacific Journal of Cancer Prevention, 2021
The aims of this research are to evaluate the expression and distribution of NFATc1 in tumor microenvironment of Hodgkin lymphoma.Twenty-eight cases of Hodgkin lymphoma were selected. Clinicopathological data of age, gender, location and subtypes were obtained.
Murti, Krisna, Neti, Neti, Kurniawati, Nyiayu Fauziah, Kartika, Ika, Rasyid, Riana Sari Puspita, Hafy, Zen   +5 more
openaire   +2 more sources

Regulation of NFATc1 in Osteoclast Differentiation [PDF]

Journal of Bone Metabolism, 2014
Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL).
Kim, Jung Ha, Kim, Nacksung
openaire   +2 more sources

Transcriptional Regulation of and by NFATc1 in Lymphocytes [PDF]

The Journal of Immunology, 2013
The transcription factor NFATc1 has been shown to regulate the activation and differentiation of T-cells and B-cells, of DCs and megakaryocytes. Dysregulation of NFAT signaling was shown to be associated with the generation of autoimmune diseases, malignant transformation and the development of cancer [71].
Matthias, Hock, Martin, Vaeth, Ronald, Rudolf, Amiya Kumar, Patra, Duong Anh Thuy, Pham, Khalid, Muhammad, Tobias, Pusch, Tobias, Bopp, Edgar, Schmitt, Rene, Rost, Friederike, Berberich-Siebelt, Dimitri, Tyrsin, Sergei, Chuvpilo, Andris, Avots, Edgar, Serfling, Stefan, Klein-Hessling   +15 more
openaire   +4 more sources

NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

eLife, 2023
The origin and differentiation mechanism of articular chondrocytes remain poorly understood. Broadly, the difference in developmental mechanisms of articular and growth-plate cartilage is still less elucidated. Here, we identified that the nuclear factor
Fan Zhang, Yuanyuan Wang, Ying Zhao, Manqi Wang, Bin Zhou, Bin Zhou, Xianpeng Ge   +6 more
doaj   +1 more source

Regulation of the Murine Nfatc1 Gene by NFATc2 [PDF]

Journal of Biological Chemistry, 2002
NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system. NFATc2 is found abundantly in the cytoplasm of resting T cells, whereas Nfatc1 expression is induced during T cell activation.
Bin, Zhou, Randy Q, Cron, Bingruo, Wu, Anna, Genin, Zhili, Wang, Steve, Liu, Paul, Robson, H Scott, Baldwin   +7 more
openaire   +2 more sources

NFATc1 and NFATc2 repress spontaneous osteoarthritis [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Currently, little is understood about how the transcriptional regulation of cartilage breakdown contributes to pathogenesis of osteoarthritis (OA). Here, we report that, within cartilage, the transcription factor Nuclear factor of activated T cells c1 (NFATc1) displays selective expression in superficial articular ...
Matthew B, Greenblatt, Susan Y, Ritter, John, Wright, Kelly, Tsang, Dorothy, Hu, Laurie H, Glimcher, Antonios O, Aliprantis   +6 more
openaire   +2 more sources

Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species

Frontiers in Pharmacology, 2021
Integrity of the skeleton is sustained through the balanced activities of osteoblasts and osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts activation commonly seen in osteoporosis.
Delong Chen, Delong Chen, Qingqing Wang, Ying Li, Ping Sun, Vincent Kuek, Jinbo Yuan, Junzheng Yang, Longfei Wen, Haibin Wang, Jiake Xu, Peng Chen   +11 more
doaj   +1 more source

The expression of nuclear factor of activated T cell c1 and receptor activator of nuclear factor kappa β induced by Enterococcus faecalis in osteoclastogenesis (laboratory experiment on Wistar rats)

Dental Journal, 2019
Background: Enterococcus faecalis (E. faecalis) is the most common bacteria species in persistent endodontic infection of teeth undergoing root canal treatment at a prevalence of 38%.
Nirawati Pribadi, Rosita Rahmawati, Mandojo Rukmo, Adelina Kristanti Tandadjaja, Hendy Jaya Kurniawan, Ratna Puspita Hadi   +5 more
doaj   +1 more source

MiR‐338 regulates NFATc1 expression and inhibits the proliferation and epithelial‐mesenchymal transition of human non‐small‐cell lung cancer cells

Molecular Genetics & Genomic Medicine, 2020
Background It is well known that nuclear factor of activated T cells c1 (NFATc1) expression is closely associated with progression of many cancers. And we found that miR‐338 could directly target the NFATc1.
Wei He, Jibin Lu
doaj   +1 more source

Do we use methylation of NFATC1 and FOS genes as a biomarker for postmenopausal osteoporosis?

Balkan Journal of Medical Genetics, 2021
Genetic and epigenetic factors have an important role during the development of osteoporosis. Receptor activator of nuclear factor-κ B (NF-κB) (RANK)/receptor activator of NF-κB ligand (RANKL) pathway is important for the bone remodeling, and NFATC1 and ...
Kalkan R, Tosun O
doaj   +1 more source