Results 21 to 30 of about 21,677 (225)

MiR‐338 regulates NFATc1 expression and inhibits the proliferation and epithelial‐mesenchymal transition of human non‐small‐cell lung cancer cells

Molecular Genetics & Genomic Medicine, 2020
Background It is well known that nuclear factor of activated T cells c1 (NFATc1) expression is closely associated with progression of many cancers. And we found that miR‐338 could directly target the NFATc1.
Wei He, Jibin Lu
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Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Cell Communication and Signaling, 2019
Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the
Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen   +13 more
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NFATc1 Induction in Peripheral T and B Lymphocytes [PDF]

The Journal of Immunology, 2013
Abstract NFAT transcription factors control the proliferation and survival of peripheral lymphocytes. We have reported previously that the short isoform NFATc1/αA whose generation is induced by immune receptor stimulation supports the proliferation and inhibits the activation-induced cell death of peripheral T and B cells.
Matthias, Hock, Martin, Vaeth, Ronald, Rudolf, Amiya Kumar, Patra, Duong Anh Thuy, Pham, Khalid, Muhammad, Tobias, Pusch, Tobias, Bopp, Edgar, Schmitt, Rene, Rost, Friederike, Berberich-Siebelt, Dimitri, Tyrsin, Sergei, Chuvpilo, Andris, Avots, Edgar, Serfling, Stefan, Klein-Hessling   +15 more
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Do we use methylation of NFATC1 and FOS genes as a biomarker for postmenopausal osteoporosis?

Balkan Journal of Medical Genetics, 2021
Genetic and epigenetic factors have an important role during the development of osteoporosis. Receptor activator of nuclear factor-κ B (NF-κB) (RANK)/receptor activator of NF-κB ligand (RANKL) pathway is important for the bone remodeling, and NFATC1 and ...
Kalkan R, Tosun O
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NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs

Frontiers in Immunology, 2022
CD4+CXCR5+Foxp3+ T-follicular regulatory (TFR) cells control the germinal center responses. Like T-follicular helper cells, they express high levels of Nuclear Factor of Activated T-cells c1, predominantly its short isoform NFATc1/αA.
Anika Koenig, Martin Vaeth, Yin Xiao, Cristina M. Chiarolla, Raghu Erapaneedi, Matthias Klein, Lena Dietz, Nadine Hundhausen, Snigdha Majumder, Felix Schuessler, Tobias Bopp, Tobias Bopp, Tobias Bopp, Tobias Bopp, Stefan Klein-Hessling, Andreas Rosenwald, Andreas Rosenwald, Ingolf Berberich, Friederike Berberich-Siebelt   +18 more
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Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]

, 2018
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy, Fan, Yao, Jalali, Aydin, Li, Bai-Yan, Liu, Shengzhi, Minami, Kazumasa, Nakshatri, Harikrishna, Ogawa, Kazuhiko, Yokota, Hiroki   +8 more
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NFATc1 activates the acetylcholinesterase promoter in rat muscle [PDF]

Journal of Neurochemistry, 2004
AbstractNuclear factor of activated T‐cells (NFAT) plays a role in the response of muscle to chronic contractile activity that can result in fiber type switching and hypertrophy. These effects are due in part to activation of target genes following Ca2+‐mediated nuclear translocation of NFAT.
Tatiana V, Cohen, William R, Randall
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
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NFATc1 regulates lymphatic endothelial development

Mechanisms of Development, 2009
NFATc1 transcription factor is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis and osteoclastogenesis. We identified a role for calcineurin-NFAT signaling in lymphatic development and patterning. NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial ...
Kulkarni, Rishikesh M., Greenberg, James M., Akeson, Ann L.   +2 more
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mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1 [PDF]

Communications Biology, 2018
AbstractRapamycins are immunosuppressant and anti-cancer drugs that inhibit the kinase mTOR. Clinically, they often cause bone pain, bone necrosis, and high bone turnover, yet the mechanisms are unclear. Here we show that mTORC1 activity is high in osteoclast precursors but downregulated upon RANKL treatment. Loss-of-function genetic models reveal that
Huynh, HoangDinh, Wan, Yihong
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