Results 21 to 30 of about 13,264 (178)

NFATc1 and NFATc2 repress spontaneous osteoarthritis [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Currently, little is understood about how the transcriptional regulation of cartilage breakdown contributes to pathogenesis of osteoarthritis (OA). Here, we report that, within cartilage, the transcription factor Nuclear factor of activated T cells c1 (NFATc1) displays selective expression in superficial articular ...
Matthew B, Greenblatt, Susan Y, Ritter, John, Wright, Kelly, Tsang, Dorothy, Hu, Laurie H, Glimcher, Antonios O, Aliprantis   +6 more
openaire   +2 more sources

Regulation of the Murine Nfatc1 Gene by NFATc2 [PDF]

Journal of Biological Chemistry, 2002
NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system. NFATc2 is found abundantly in the cytoplasm of resting T cells, whereas Nfatc1 expression is induced during T cell activation.
Bin, Zhou, Randy Q, Cron, Bingruo, Wu, Anna, Genin, Zhili, Wang, Steve, Liu, Paul, Robson, H Scott, Baldwin   +7 more
openaire   +2 more sources

Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species

Frontiers in Pharmacology, 2021
Integrity of the skeleton is sustained through the balanced activities of osteoblasts and osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts activation commonly seen in osteoporosis.
Delong Chen, Delong Chen, Qingqing Wang, Ying Li, Ping Sun, Vincent Kuek, Jinbo Yuan, Junzheng Yang, Longfei Wen, Haibin Wang, Jiake Xu, Peng Chen   +11 more
doaj   +1 more source

NFATc1 controls the cytotoxicity of CD8+ T cells [PDF]

Nature Communications, 2017
AbstractCytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 −/− cytotoxic T lymphocytes showed a defective cytoskeleton organization and ...
Stefan Klein-Hessling, Khalid Muhammad, Matthias Klein, Tobias Pusch, Ronald Rudolf, Jessica Flöter, Musga Qureischi, Andreas Beilhack, Martin Vaeth, Carsten Kummerow, Christian Backes, Rouven Schoppmeyer, Ulrike Hahn, Markus Hoth, Tobias Bopp, Friederike Berberich-Siebelt, Amiya Patra, Andris Avots, Nora Müller, Almut Schulze, Edgar Serfling   +20 more
openaire   +4 more sources

The expression of nuclear factor of activated T cell c1 and receptor activator of nuclear factor kappa β induced by Enterococcus faecalis in osteoclastogenesis (laboratory experiment on Wistar rats)

Dental Journal, 2019
Background: Enterococcus faecalis (E. faecalis) is the most common bacteria species in persistent endodontic infection of teeth undergoing root canal treatment at a prevalence of 38%.
Nirawati Pribadi, Rosita Rahmawati, Mandojo Rukmo, Adelina Kristanti Tandadjaja, Hendy Jaya Kurniawan, Ratna Puspita Hadi   +5 more
doaj   +1 more source

MiR‐338 regulates NFATc1 expression and inhibits the proliferation and epithelial‐mesenchymal transition of human non‐small‐cell lung cancer cells

Molecular Genetics & Genomic Medicine, 2020
Background It is well known that nuclear factor of activated T cells c1 (NFATc1) expression is closely associated with progression of many cancers. And we found that miR‐338 could directly target the NFATc1.
Wei He, Jibin Lu
doaj   +1 more source

NFATc1 activates the acetylcholinesterase promoter in rat muscle [PDF]

Journal of Neurochemistry, 2004
AbstractNuclear factor of activated T‐cells (NFAT) plays a role in the response of muscle to chronic contractile activity that can result in fiber type switching and hypertrophy. These effects are due in part to activation of target genes following Ca2+‐mediated nuclear translocation of NFAT.
Tatiana V, Cohen, William R, Randall
openaire   +2 more sources

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Cell Communication and Signaling, 2019
Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the
Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen   +13 more
doaj   +1 more source

Do we use methylation of NFATC1 and FOS genes as a biomarker for postmenopausal osteoporosis?

Balkan Journal of Medical Genetics, 2021
Genetic and epigenetic factors have an important role during the development of osteoporosis. Receptor activator of nuclear factor-κ B (NF-κB) (RANK)/receptor activator of NF-κB ligand (RANKL) pathway is important for the bone remodeling, and NFATC1 and ...
Kalkan R, Tosun O
doaj   +1 more source

Mitf regulates osteoclastogenesis by modulating NFATc1 activity [PDF]

Experimental Cell Research, 2014
Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible that the two factors work together to promote osteoclastogenesis.
Ssu-Yi Lu, Mengtao Li, Yi-Ling Lin
openaire   +4 more sources