Results 31 to 40 of about 13,264 (178)
Vitamin Regulation of Osteoclast Differentiation
Central Asian Journal of Medical Sciences, 2020 Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu +5 more
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Cells, 2022 Hematopoietic stem and progenitor cell (HSPC) maintenance and the differentiation of various lineages is a highly complex but precisely regulated process.
Carlotta Barahona de Brito +3 more
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eLife, 2015 Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone-degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled ...
Xiaoxiao Li +5 more
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NFATc1 regulates lymphatic endothelial development
Mechanisms of Development, 2009 NFATc1 transcription factor is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis and osteoclastogenesis. We identified a role for calcineurin-NFAT signaling in lymphatic development and patterning. NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial ...
Kulkarni, Rishikesh M. +2 more
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Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity
Journal of Experimental Medicine, 2020 Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its role in
Yin Xiao +16 more
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Atypical behavior of NFATc1 in cultured intercostal myofibers [PDF]
Skeletal Muscle, 2014 Abstract Background The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control the fiber type in response to muscle activity.
Robison, Patrick +2 more
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The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis [PDF]
International Journal of Molecular Sciences, 2020 The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation.
Jung Yun Kang +4 more
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OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice. [PDF]
PLoS ONE, 2013 BACKGROUND: Our previous studies have shown that OX40-OX40L interaction regulates the expression of nuclear factor of activated T cells c1(NFATc1) in ApoE(-/-) mice during atherogenesis.
Jinchuan Yan +3 more
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Solution Structure of the Core NFATC1/DNA Complex [PDF]
Cell, 1998 The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
Zhou, Pei +4 more
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Drug Design, Development and Therapy, 2020 Jiaxuan Peng,1,* Kangxian Zhao,2,* Jiling Zhu,3,* Yanben Wang,4,5 Peng Sun,2 Qichang Yang,2 Tan Zhang,4 Weiqi Han,4 Wenjun Hu,4 Wanlei Yang,4 Jianwei Ruan,6 Yu Qian1,2,4 1Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University ...
Peng J +11 more
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