Results 31 to 40 of about 16,913 (200)

NFATc1 activates the acetylcholinesterase promoter in rat muscle [PDF]

Journal of Neurochemistry, 2004
AbstractNuclear factor of activated T‐cells (NFAT) plays a role in the response of muscle to chronic contractile activity that can result in fiber type switching and hypertrophy. These effects are due in part to activation of target genes following Ca2+‐mediated nuclear translocation of NFAT.
Tatiana V, Cohen, William R, Randall
openaire   +2 more sources

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Cell Communication and Signaling, 2019
Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the
Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen   +13 more
doaj   +1 more source

Vitamin Regulation of Osteoclast Differentiation

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +1 more source

Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1

Cells, 2022
Hematopoietic stem and progenitor cell (HSPC) maintenance and the differentiation of various lineages is a highly complex but precisely regulated process.
Carlotta Barahona de Brito, Stefan Klein-Hessling, Edgar Serfling, Amiya Kumar Patra   +3 more
doaj   +1 more source

Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

eLife, 2015
Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone-degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled ...
Xiaoxiao Li, Wei Wei, HoangDinh Huynh, Hao Zuo, Xueqian Wang, Yihong Wan   +5 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation [PDF]

Advanced science
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Liang H, Xiao Y, Luo J, Yang X, Yang Y, Wu Q, Yu C, Zhou Z, Si X, Miao J, Tu Y, Lu Q, Qian B, Wang X, Xu J, Shi C, Jin H.   +16 more
europepmc   +2 more sources

Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Journal of Experimental Medicine, 2020
Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its role in
Yin Xiao, Musga Qureischi, Lena Dietz, Martin Vaeth, Subrahmanya D. Vallabhapurapu, Stefan Klein-Hessling, Matthias Klein, Chunguang Liang, Anika König, Edgar Serfling, Anja Mottok, Tobias Bopp, Andreas Rosenwald, Mathias Buttmann, Ingolf Berberich, Andreas Beilhack, Friederike Berberich-Siebelt   +16 more
openaire   +2 more sources

NFATc1 regulates lymphatic endothelial development

Mechanisms of Development, 2009
NFATc1 transcription factor is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis and osteoclastogenesis. We identified a role for calcineurin-NFAT signaling in lymphatic development and patterning. NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial ...
Kulkarni, Rishikesh M., Greenberg, James M., Akeson, Ann L.   +2 more
openaire   +2 more sources

Atypical behavior of NFATc1 in cultured intercostal myofibers [PDF]

Skeletal Muscle, 2014
Abstract Background The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control the fiber type in response to muscle activity.
Robison, Patrick, Hernández-Ochoa, Erick O, Schneider, Martin F   +2 more
openaire   +2 more sources

The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis [PDF]

International Journal of Molecular Sciences, 2020
The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation.
Jung Yun Kang, Namju Kang, Yu-Mi Yang, Jeong Hee Hong, Dong Min Shin   +4 more
openaire   +3 more sources