Results 31 to 40 of about 21,677 (225)

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]

, 2010
DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E, Antonenko, Svetlana, Bigler, Michael E, Blumenschein, Wendy M, Bowman, Edward P, Chao, Cheng-Chi, Cua, Daniel J, Heyworth, Paul G, Joyce-Shaikh, Barbara, McClanahan, Terrill K, Murphy, Erin E, Phillips, Joseph H   +11 more
core   +3 more sources

Vitamin Regulation of Osteoclast Differentiation

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +1 more source

Gene Expression Profiling of NFATc1-Knockdown in RAW 264.7 Cells: An Alternative Pathway for Macrophage Differentiation

Cells, 2019
NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood.
Roberta Russo, Selene Mallia, Francesca Zito, Nadia Lampiasi   +3 more
doaj   +1 more source

Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1

Cells, 2022
Hematopoietic stem and progenitor cell (HSPC) maintenance and the differentiation of various lineages is a highly complex but precisely regulated process.
Carlotta Barahona de Brito, Stefan Klein-Hessling, Edgar Serfling, Amiya Kumar Patra   +3 more
doaj   +1 more source

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells [PDF]

, 2016
Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease.
A Johnston, A Kaczmarek, A Nast, A Nayak, A Roers, A Saxena, A Walter, A Yoshizaki, B Flutter, C Loh, C Mauri, C Scholz, E Hobeika, E Serfling, E Soutoglou, EC Rosser, EF Wagner, F Berberich-Siebelt, GJ Martinez, GK Perera, H Blumberg, H Li, H Vinter, H Vinter, HB Schonthaler, J Mehta, J Rengarajan, J Skrzeczynska-Moncznik, K Asadullah, K Guilloteau, K Miles, K Muhammad, K Yanaba, K Yanaba, K Yanaba, KE Kolodziej, L Dietz, M Dannappel, M Gilliet, M Hock, M Matsumoto, M Pasparakis, M Yang, MA Lowes, MC Bonnet, MP Schon, MP Schon, PA Blair, PG Hogan, PJ Hampton, PJ Mease, R Lande, R Weinlich, S Benoit, S Bhattacharyya, S Chuvpilo, S McManus, S Tenzer, T Nojima, U Distler, VC Kyttaris, WI Al-Daraji, WI Al-Daraji   +62 more
core   +2 more sources

Atypical behavior of NFATc1 in cultured intercostal myofibers [PDF]

Skeletal Muscle, 2014
Abstract Background The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control the fiber type in response to muscle activity.
Robison, Patrick, Hernández-Ochoa, Erick O, Schneider, Martin F   +2 more
openaire   +2 more sources

Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

eLife, 2015
Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone-degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled ...
Xiaoxiao Li, Wei Wei, HoangDinh Huynh, Hao Zuo, Xueqian Wang, Yihong Wan   +5 more
doaj   +1 more source

A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]

, 2017
Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core   +3 more sources

Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1 [PDF]

Journal of Clinical Medicine, 2018
Osteoporosis is a disease characterized by osteoclast-mediated low bone mass. The modulation of osteoclasts is important for the prevention or therapeutic treatment of loss of bone mass. Osteoclasts, which are bone-resorbing multinucleated cells, are differentiated from the hematopoietic stem cell monocyte/macrophage lineage by Receptor activator of ...
Kwang-Jin Kim, Yongjin Lee, Hae-Gwang Hwang, Sang Sung, Mina Lee, Young-Jin Son   +5 more
openaire   +2 more sources

Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Journal of Experimental Medicine, 2020
Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its role in
Yin Xiao, Musga Qureischi, Lena Dietz, Martin Vaeth, Subrahmanya D. Vallabhapurapu, Stefan Klein-Hessling, Matthias Klein, Chunguang Liang, Anika König, Edgar Serfling, Anja Mottok, Tobias Bopp, Andreas Rosenwald, Mathias Buttmann, Ingolf Berberich, Andreas Beilhack, Friederike Berberich-Siebelt   +16 more
openaire   +2 more sources