Results 51 to 60 of about 15,571 (214)
iScience, 2022 Summary: The Mammary gland undergoes complicated epithelial remodeling to form lobuloalveoli during pregnancy, in which basal epithelial cells remarkably increase to form a basket-like architecture. However, it remains largely unknown how dormant mammary
Ruiqi Liu +11 more
doaj +1 more source
Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis
International Archives of Otorhinolaryngology, 2016 Introduction The structural changes underlying permanent noise-induced hearing loss (NIHL) include loss of the sensory hair cells, damage to their stereocilia, and supporting tissues within the cochlear lateral wall.
Tengku Siti Hajar Haryuna +5 more
doaj +1 more source
Transforming growth factor-β enables NFATc1 expression during osteoclastogenesis [PDF]
, 2007 Osteoclastogenesis is dependent on distinct stimuli that prime and activate osteoclast differentiation. One cytokine needed to prime monocytes for osteoclastogenesis is TGF-β, which enables and augments RANKL and TNF-α-induced osteoclast differentiation.
Evans, K.E. +8 more
core +2 more sources
Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways. [PDF]
PLoS ONE, 2014 Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated.
Teruhito Yamashita +7 more
doaj +1 more source
MicroRNA-mediated control of developmental lymphangiogenesis
eLife, 2019 The post-transcriptional mechanisms contributing to molecular regulation of developmental lymphangiogenesis and lymphatic network assembly are not well understood. MicroRNAs are important post-transcriptional regulators during development.
Hyun Min Jung +7 more
doaj +1 more source
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1 [PDF]
Communications Biology, 2018 AbstractRapamycins are immunosuppressant and anti-cancer drugs that inhibit the kinase mTOR. Clinically, they often cause bone pain, bone necrosis, and high bone turnover, yet the mechanisms are unclear. Here we show that mTORC1 activity is high in osteoclast precursors but downregulated upon RANKL treatment. Loss-of-function genetic models reveal that
Huynh, HoangDinh, Wan, Yihong
openaire +2 more sources
AUTOREGULATION DES NFATc1 GEN [PDF]
, 2008 Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt.
Tyrsin, Dmitry
core
Molecules, 2019 Osteoporosis is a disease that leads to reduced bone mineral density. The increase in patient and medical costs because of global aging is recognized as a problem.
Kwang-Jin Kim +6 more
doaj +1 more source
Children, 2023 Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial changes in children with BAV ...
Andrii Kamenshchyk +3 more
doaj +1 more source