Results 51 to 60 of about 16,913 (200)
MicroRNA-mediated control of developmental lymphangiogenesis
eLife, 2019 The post-transcriptional mechanisms contributing to molecular regulation of developmental lymphangiogenesis and lymphatic network assembly are not well understood. MicroRNAs are important post-transcriptional regulators during development.
Hyun Min Jung +7 more
doaj +1 more source
TRANSKRIPTIONSMECHANISMEN UND FUNKTIONEN VON NFATC1 IN LYMPHOZYTEN
, 2007 The Nuclear Factors of Activated T cells (NFATs) are critical transcription factors that direct gene expression in immune and non-immune cells. Interaction of T cells with Ag-presenting cells results in the clustering of T-cell antigen receptor (TCR), co-
Liu, Jiming
core +2 more sources
Molecules, 2019 Osteoporosis is a disease that leads to reduced bone mineral density. The increase in patient and medical costs because of global aging is recognized as a problem.
Kwang-Jin Kim +6 more
doaj +1 more source
Advanced Science, EarlyView.This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li +8 more
wiley +1 more source
, 2008 Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt.
Tyrsin, Dmitry
core +2 more sources
mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1 [PDF]
Communications Biology, 2018 Abstract Rapamycins are immunosuppressant and anti-cancer drugs that inhibit the kinase mTOR. Clinically, they often cause bone pain, bone necrosis, and high bone turnover, yet the mechanisms are unclear. Here we show that mTORC1 activity is high in osteoclast precursors but downregulated upon RANKL treatment. Loss-of-function genetic
Huynh, HoangDinh, Wan, Yihong
openaire +2 more sources
Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation
Frontiers in Immunology, 2018 In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in ...
Khalid Muhammad +8 more
doaj +1 more source
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network [PDF]
, 2011 By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B cells upon B cell receptor (BCR ...
Duong Anh Thuy Pham +43 more
core +1 more source
Children, 2023 Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial changes in children with BAV ...
Andrii Kamenshchyk +3 more
doaj +1 more source