Results 61 to 70 of about 16,913 (200)
Advanced Science, EarlyView.Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou +11 more
wiley +1 more source
RCANs regulate the convergent roles of NFATc1 in bone homeostasis [PDF]
Scientific Reports, 2016 AbstractActivation of calcineurin-dependent nuclear factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis. NFATc1 regulates both osteoclastogenesis and osteoblastogenesis. Here we investigated the roles of regulator of calcineurin (RCAN) genes in bone homeostasis.
Kim, Jung Ha +8 more
openaire +3 more sources
NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract
Translational Oncology, 2017 We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression.
Takashi Kawahara +8 more
doaj +1 more source
Saudi Dental Journal, 2021 Objective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1.
Utari Kresnoadi +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.This study dynamically charts the developmental process of the knee joint cartilage from the embryonic stage through to postnatal life, revealing key developmental events including the origin of knee joint development, chondrification, primary ossification, secondary ossification, formation of the cartilage cancal, and formation of the growth plate. It
Yan Nie +9 more
wiley +1 more source
Activated NFATc1 negatively modulates Sp1 nuclear content.
, 2013 (A) HK-2 cells were untreated (c) or treated with CsA 10nM, NGF 100ng/ml alone or in combination for 15h before lysis. Nuclear and cytosolic expression of NFATc1 (Antibody dilution 1:100) and Sp1 (1:1000) were evaluated.
Donatella Vizza (480988) +8 more
core +1 more source
Transforming growth factor-β enables NFATc1 expression during osteoclastogenesis [PDF]
, 2007 Osteoclastogenesis is dependent on distinct stimuli that prime and activate osteoclast differentiation. One cytokine needed to prime monocytes for osteoclastogenesis is TGF-β, which enables and augments RANKL and TNF-α-induced osteoclast differentiation.
Evans, KE +5 more
core +1 more source
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells [PDF]
Cell, 2008 Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP ...
Horsley, Valerie +4 more
openaire +2 more sources
Analysis of NFATc1 gene expression using eGFP-BAC reporter mice
, 2013 In Lymphozyten wird nach Antigenaktivierung die Expression des Nfatc1-Gens durch Aktivierung des P1-Promoters stark induziert. Dagegen ist die, durch den Promoter P2 vermittelte Expression ebenso wie die der anderen NFAT Faktoren c2 und c3 konstitutiv ...
Hock, Matthias
core +2 more sources
Arthritis &Rheumatology, EarlyView.Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim +14 more
wiley +1 more source