Results 61 to 70 of about 15,571 (214)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence [PDF]

, 2016
Despite recent insights into prostate cancer (PCa)-associated genetic changes, full understanding of prostate tumorigenesis remains elusive owing to complexity of interactions among various cell types and soluble factors present in prostate tissue.
Tripathi, P., Humphrey, P. A., Ding, L., Zhang, Hong, Maher, C. A., Liapis, H., Ning, J., Ruzinova, M. B., Manda, K. R., Chen, F., Hsi, A. C., Bailey, M., You, Z., Andriole, G. L.   +13 more
core   +1 more source

Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation

Frontiers in Immunology, 2018
In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in ...
Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Katsuyoshi Takata, Nobuko Matsushita, Volker Ellenrieder, Eisaku Kondo, Edgar  Serfling   +8 more
doaj   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Sumolierung moduliert die NFATc1-vermittele Lymphokin Genexpression [PDF]

, 2007
Die Aktivität von Transkriptionsfaktoren kann durch die Modifikation mit SUMO positiv oder negativ beeinflusst werden, indem Protein-Protein-Interaktionen als auch die subzelluläre bzw. subnukleäre Lokalisation verändert werden.
Nayak, Arnab
core  

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

BMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen, Haoyue Hu, Danyang Wang, Ying Wang, Zhibang Li, Xiaoyi Liu, Yandi Zhang, Junkun Feng, Weiwei Zhao, Kai Li, Qi‐Zhi Zhong, Shaohua Ge, Jianhua Li   +12 more
wiley   +1 more source

RCANs regulate the convergent roles of NFATc1 in bone homeostasis [PDF]

Scientific Reports, 2016
AbstractActivation of calcineurin-dependent nuclear factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis. NFATc1 regulates both osteoclastogenesis and osteoblastogenesis. Here we investigated the roles of regulator of calcineurin (RCAN) genes in bone homeostasis.
Kim, Jung Ha, Kim, Kabsun, Kim, Inyoung, Seong, Semun, Jeong, Byung-chul, Nam, Kwang-Il, Kim, Kyung Keun, Molkentin, Jeffery D., Kim, Nacksung   +8 more
openaire   +3 more sources

TRANSKRIPTIONSMECHANISMEN UND FUNKTIONEN VON NFATC1 IN LYMPHOZYTEN [PDF]

, 2007
The Nuclear Factors of Activated T cells (NFATs) are critical transcription factors that direct gene expression in immune and non-immune cells. Interaction of T cells with Ag-presenting cells results in the clustering of T-cell antigen receptor (TCR), co-
Liu, Jiming
core  

DSF inhibited RANKL-induced NFATc1 signaling. [PDF]

, 2015
(A) DSF attenuated RANKL-induced NFATc1 protein expression. Total cell lysates were extracted from BMMs treated with rRANKL for 0, 24, 48 and 72 hrs in the presence or absence of DSF (100nM).
An Qin (172006), Nathan J. Pavlos (172028), Ming H. Zheng (197848), Sarah Rea (732989), Hua Ying (47308), Kerong Dai (387141), Tak S. Cheng (172011)   +6 more
core   +1 more source

Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1

Saudi Dental Journal, 2021
Objective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1.
Utari Kresnoadi, Jennifer Widjaja, Harry Laksono   +2 more
doaj   +1 more source