Results 61 to 70 of about 21,677 (225)

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Water Extracts of Hull-less Waxy Barley (Hordeum vulgare L.) Cultivar ‘Boseokchal’ Inhibit RANKL-induced Osteoclastogenesis

Molecules, 2019
Osteoporosis is a disease that leads to reduced bone mineral density. The increase in patient and medical costs because of global aging is recognized as a problem.
Kwang-Jin Kim, Yongjin Lee, So-Ri Son, Hyunjin Lee, Young-Jin Son, Mi-Kyung Lee, Mija Lee   +6 more
doaj   +1 more source

Association of Myocardial Changes and Gene Expression of the NFATC1 and NFATC4—Calcineurin Signaling Pathway in Children with Bicuspid Aortic Valve

Children, 2023
Background: The role of NFATC gene expression in bicuspid aortic valve (BAV) progression is not fully understood. The aim of this study is to determine the significance of NFATC1 and NFATC4 gene expression for myocardial changes in children with BAV ...
Andrii Kamenshchyk, Margaryta Gonchar, Valentyn Oksenych, Aleksandr Kamyshnyi   +3 more
doaj   +1 more source

Requirement of Activation for Hepatitis B Virus Infection [PDF]

, 2007
Although _in vitro_ models of human hepatitis B virus replication are established, so far none could approximate infection efficiency as expected from _in vivo_ observations.
Claudia Maenz, Michael Bruns
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. [PDF]

, 2010
In contrast to conventional dual-energy X-ray absorptiometry, quantitative computed tomography separately measures trabecular and cortical volumetric bone mineral density (vBMD).
Barrett-Connor, Elizabeth, Cauley, Jane A, Ensrud, Kristine E, Ferrell, Robert E, Hoffman, Andrew R, Kammerer, Candace M, Klei, Lambertus, Lang, Thomas F, Lewis, Cora, Moffett, Susan P, Nestlerode, Cara S, Orwoll, Eric S, Osteoporotic Fractures in Men (MrOS) Study Group, Roeder, Kathryn, Yerges, Laura M, Zmuda, Joseph M   +15 more
core  

Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone [PDF]

, 2011
Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents.
Correro, R M, Ghayor, C, Grätz, K W, Karfeld-Sulzer, L S, Lange, K, Weber, Franz E   +5 more
core   +1 more source

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors [PDF]

Journal of the American Society of Nephrology, 2009
Recovery from acute kidney injury requires regeneration of tubule cells. Because calcineurin induces nuclear transport of NFATc proteins, whose expression pattern correlates with the nephron segments injured by calcineurin inhibitors, we hypothesized that NFATc1 plays a role in modifying epithelial regeneration after injury.
Melissa, Langworthy, Bin, Zhou, Mark, de Caestecker, Gilbert, Moeckel, H Scott, Baldwin   +4 more
openaire   +2 more sources

Ethanol extract of propolis-bovine bone graft combination as a prospective candidate for socket preservation: Enhancing BMP7 and decreasing NFATc1

Saudi Dental Journal, 2021
Objective: To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1.
Utari Kresnoadi, Jennifer Widjaja, Harry Laksono   +2 more
doaj   +1 more source