Results 81 to 90 of about 21,677 (225)
ThPOK Inhibits Osteoclast Formation Via NFATc1 Transcription and Function
JBMR Plus, 2022 Both LRF (Zbtb7a) and ThPOK (Zbtb7b) belong to the POK (BTB/POZ and Kruppel) family of transcription repressors that participate in development, differentiation, and oncogenesis.
Wei Zou +5 more
doaj +1 more source
Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma cells
Frontiers in Oncology, 2023 In Burkitt lymphoma (BL), a tumor of germinal center B cells, the pro-apoptotic properties of MYC are controlled by tonic B cell receptor (BCR) signals. Since BL cells do not exhibit constitutive NF-κB activity, we hypothesized that anti-apoptotic NFATc1
Krisna Murti +9 more
doaj +1 more source
Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis [PDF]
, 2014 Wnt signaling plays a major role in bone homeostasis and mechanotransduction, but its role and regulatory mechanism in osteoclast development are not fully understood.
Chen, Andy +5 more
core +1 more source
BMEMat, EarlyView.This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen +12 more
wiley +1 more source
Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
Scientific ReportsAbstractAging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limited skeletal muscles.
Jin-Man Kim +8 more
openaire +3 more sources
Biochemical and Biophysical Research Communications, 2021 Receptor Activator of NF-κB (RANK) expressed on osteoclasts and their precursors is a receptor for RANK ligand (RANKL). Signals transduced by RANKL-RANK interaction induce genes essential for the differentiation and function of osteoclasts, partly through the direct binding of NFATc1, to target gene promoters.
Riko Kitazawa +3 more
openaire +2 more sources
NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation
iScience, 2023 Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development ...
Sabrina Giampaolo +10 more
doaj +1 more source
Food Safety and Health, EarlyView.In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso +3 more
wiley +1 more source
Scientific ReportsThe Nuclear Factor of Activated T-cells cytoplasmic 1 (NFATc1) is identified to be an oncogene in several human cancers. However, its specific role in HCC progression and the relevant mechanisms remain unclear.
Zhaobin Chen +7 more
doaj +1 more source
The Direct Effect of Low-Magnitude High-Frequency Mechanical Vibration on Osteoclast Formation from RAW267.4 Monocytes [PDF]
, 2015 Low-magnitude high-frequency (LMHF) mechanical vibration has been demonstrated to enhance bone formation possibly through inhibition of osteoclastogenesis of bone.
Abraham, Maxwell Antonio
core +1 more source