Results 81 to 90 of about 15,571 (214)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley +1 more source
RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation [PDF]
, 2011 NFATc1 (nuclear factor of activated T-cells c1), a key transcription factor, plays a role in regulating expression of osteoclast-specific downstream target genes such as TRAP (tartrate-resistant acid phosphatase) and OSCAR (osteoclast-associated receptor)
Jung Ha Kim +9 more
core +1 more source
NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation
iScience, 2023 Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development ...
Sabrina Giampaolo +10 more
doaj +1 more source
Journal of Clinical Periodontology, EarlyView.ABSTRACT Aim To investigate whether local administration of sodium tanshinone IIA sulfonate (STS) modulates periodontal inflammation, alveolar bone loss, immune response and bone remodelling–related signalling pathways in a ligature‐induced murine model of periodontitis.
Rafael Scaf de Molon +11 more
wiley +1 more source
NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors [PDF]
Journal of the American Society of Nephrology, 2009 Recovery from acute kidney injury requires regeneration of tubule cells. Because calcineurin induces nuclear transport of NFATc proteins, whose expression pattern correlates with the nephron segments injured by calcineurin inhibitors, we hypothesized that NFATc1 plays a role in modifying epithelial regeneration after injury.
Melissa, Langworthy +4 more
openaire +2 more sources
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling
Journal of Periodontal Research, EarlyView.Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon +4 more
wiley +1 more source
NFATc1 self-promotes to build bone [PDF]
The Journal of Experimental Medicine, 2005 Self-promotion is the way to get ahead during bone development, according to Asagiri and colleagues. They show on page 1261 that the inducible transcription factor NFATc1 must turn on its own expression for bone-resorbing osteoclasts to form. Figure NFATc1-deficient mice (right) lack osteoclasts and thus have abnormally dense bones.
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B cell development is critically dependent on NFATc1 activity [PDF]
Cellular & Molecular Immunology, 2018 B cell development in bone marrow is a precisely regulated complex process. Through successive stages of differentiation, which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors, the common lymphoid progenitors ultimately give rise to mature B cells.
Giampaolo, Sabrina +4 more
openaire +3 more sources
ThPOK Inhibits Osteoclast Formation Via NFATc1 Transcription and Function
JBMR Plus, 2022 Both LRF (Zbtb7a) and ThPOK (Zbtb7b) belong to the POK (BTB/POZ and Kruppel) family of transcription repressors that participate in development, differentiation, and oncogenesis.
Wei Zou +5 more
doaj +1 more source
Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw
Oral Diseases, EarlyView.ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park +5 more
wiley +1 more source