Results 91 to 100 of about 16,913 (200)

Transcription factor decoy against NFATc1 in human primary osteoblasts

, 2011
The present study describes, for the first time, the removal of the nuclear factor of activated T cells cytoplasmic 1 (NFATc1) by a decoy approach in human primary osteoblasts (hOBs). hOBs with different NFATc1 expression levels were used.
LAMBERTINI, Elisabetta, LOLLI, Andrea, TORREGGIANI, Elena, PENOLAZZI, Maria Letizia, Facchini A, GAMBARI, Roberto, Penolazzi L., FACCHINI, ANDREA, Ciardo F, Manferdini C., Piva R., VECCHIATINI, Renata, Lambertini E., Vecchiatini R., Lisignoli G., Gabusi E, Lisignoli G, Manferdini C, Torreggiani E., Ciardo F., Lolli A., Gabusi E., Gambari R., PIVA, Maria Roberta, Roberta Piva   +24 more
core   +1 more source

Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

Immunity, Inflammation and Disease, 2020
Background We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies.
Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto   +11 more
doaj   +1 more source

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway [PDF]

, 2013
BACKGROUND: Zinc, an essential trace element, inhibits osteoclast differentiation in vitro and in vivo. The molecular mechanism for the inhibitory effect of zinc, however, is poorly understood.
신동민, 박보령, 이진우, 박전한, 이재면, 이현규, 박광환   +6 more
core   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Journal of Hematology & Oncology, 2019
Background Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome.
Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. Göthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp, Andreas Burchert   +13 more
doaj   +1 more source

Effect of arctigenin on osteoclast-like cell formation induced by the forced expression of NFATc1.

, 2014
(A) Osteoclast-like cell formation in BMM cultures. BMMs were retrovirally transduced with constitutively active (ca)-NFATc1, wild-type (wt)-NFATc1, or control GFP genes, and cultured for 2 days in the presence of M-CSF.
Shigetoshi Kadota (510441), Hiroyasu Esumi (392822), Naoyuki Takahashi (937), Feng Li (30515), Yasuhiro Kobayashi (510442), Nobuyuki Udagawa (934), Shunsuke Uehara (510440), Teruhito Yamashita (510439)   +7 more
core   +1 more source

In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

Journal of Pharmacological Sciences, 2015
The mitogen activated protein kinase p38 plays a role in the receptor activator of NF-ĸB ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated the effect of p38 inhibitor doramapimod on the osteoclast differentiation ...
Seong-Hee Moon, Sik-Won Choi, Seong Hwan Kim   +2 more
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source