Results 91 to 100 of about 13,264 (178)

Synergistic roles of NFATc1 and c-Jun in immunomodulation

Biochemistry and Biophysics Reports
The immune system relies on precise regulatory mechanisms, with transcription factors being central to modulating immune responses. NFATc1 and c-Jun are key transcription factors that influence both adaptive and innate immunity. This review provides a comprehensive examination of the individual and synergistic roles of NFATc1 and c-Jun in immune ...
Bo Cao, Renqian Wei
openaire   +3 more sources

CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway

Mediators of Inflammation, 2015
Our previous study proved that CD137-CD137L interaction can regulate the expression of NFATc1. Here, we investigated whether CD137 signaling regulates the expression of NFATc1 in mice VSMCs through TRAF6/NF-κB p65 pathway.
Jinchuan Yan, Yunjie Yin, Wei Zhong, Cuiping Wang, Zhongqun Wang   +4 more
doaj   +1 more source

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

Frontiers in Immunology, 2018
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots   +12 more
doaj   +1 more source

Osteoblast‐Derived Osteomodulin Suppresses Bone Loss in Osteoporosis by Inhibiting Osteoclastogenesis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Osteoblast‐derived matricellular protein osteomodulin (OMD) critically regulates bone remodeling homeostasis via directly and competitively binding to RANKL, the master cytokine driving osteoclast formation. OMD shares overlapping binding sites on RANKL with osteoprotegerin and functional receptor RANK.
Meiling Jing, Xiaohan Zhu, Yueyi Yang, Xuchen Hu, Wenduo Tan, Xiaoyu Liu, Yujie Zhang, Xin Wang, Chenguang Niu, Zhengwei Huang   +9 more
wiley   +1 more source

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This graphical abstract illustrates that SCD1 inhibition by A939572 or the targeted nanovesicle POCM‐NP@A939572 reprograms arachidonic acid metabolism via the COX1‐HPGDS‐PGD2 axis and impairs mitochondrial homeostasis, thereby suppressing osteoclastogenesis and alleviating bone loss in osteoporosis.
Yihao Zhao, Xiaoan Wei, Haihao Wu, Chengjun Yao, Zeyu Zheng, Weishao Chen, Zhenhua Feng, Bao Huang, Zimin Cai, Qize Xue, Jian Chen, Fengdong Zhao, Junhui Liu   +12 more
wiley   +1 more source

Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

BMC Cell Biology, 2007
Background IL-10 has a potent inhibitory effect on osteoclastogenesis. In vitro and in vivo studies confirm the importance of this cytokine in bone metabolism, for instance IL-10-deficient mice develop the hallmarks of osteoporosis.
Fox Simon W, Evans Kathryn E
doaj   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Two Heterozygous Mutations in NFATC1 in a Patient with Tricuspid Atresia

PLoS ONE, 2012
Tricuspid Atresia (TA) is a rare form of congenital heart disease (CHD) with usually poor prognosis in humans. It presents as a complete absence of the right atrio-ventricular connection secured normally by the tricuspid valve. Defects in the tricuspid valve are so far not associated with any genetic locus, although mutations in numerous genes were ...
Zahi Abdul-Sater, Amin Yehya, Jean Beresian, Elie Salem, Amina Kamar, Serine Baydoun, Kamel Shibbani, Ayman Soubra, Fadi Bitar, Georges Nemer   +9 more
openaire   +4 more sources

Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma

Cancer Cell International
Background This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE ...
Hui-Jen Tsai, Kun-Huei Yeh, Chung-Wu Lin, Ming-Shiang Wu, Jyh-Ming Liou, Ping-Ning Hsu, Yi-Shin Zeng, Ming-Feng Wei, Chia-Tung Shun, Hsiu-Po Wang, Li-Tzong Chen, Ann-Lii Cheng, Sung-Hsin Kuo   +12 more
doaj   +1 more source