Results 91 to 100 of about 15,571 (214)

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1 [PDF]

Experimental & Molecular Medicine, 2015
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone cells has not yet been well characterized.
Song, Min-Kyoung, Lee, Zang Hee, Kim, Hong-Hee   +2 more
openaire   +2 more sources

The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis

Cellular & Molecular Biology Letters, 2023
Background Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases.
Tao Yang, Renyi Hei, Xiaosong Li, Tianhua Ma, Yifen Shen, Chao Liu, Wen He, Lin Zhu, Yongchun Gu, Yanping Hu, Wenbin Wei, Yihang Shen   +11 more
doaj   +1 more source

Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry

Periodontology 2000, EarlyView.
Abstract The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated.
Nima Farshidfar, Karol Alí Apaza Alccayhuaman, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron   +6 more
wiley   +1 more source

NFATc1/alphaA: The other Face of NFAT Factors in Lymphocytes [PDF]

, 2012
In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling, Edgar, Berberich-Siebelt, Friederike, Vaeth, Martin, Rudolf, Ronald, Avots, Andris, Klein-Hessling, Stefan   +5 more
core  

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

NFATC1 promotes epicardium-derived cell invasion into myocardium [PDF]

, 2011
Epicardium-derived cells (EPDCs) contribute to formation of coronary vessels and fibrous matrix of the mature heart. Nuclear factor of activated T-cells cytoplasmic 1 (NFATC1) is expressed in cells of the proepicardium (PE), epicardium and EPDCs in mouse
Katherine E. Yutzey, Alexander W. Lange, Michelle D. Combs, Caitlin M. Braitsch, Jeanne F. James   +4 more
core   +1 more source

Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

Immunity, Inflammation and Disease, 2020
Background We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies.
Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto   +11 more
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source