Results 91 to 100 of about 21,677 (225)

Smoking is Associated with Hypermethylation of the APC 1A Promoter in Colorectal Cancer: the ColoCare Study [PDF]

, 2017
Smoking tobacco is a known risk factor for the development of colorectal cancer, and for mortality associated with the disease. While smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, there ...
Abbenhardt-Martin, C, Barrow, Timothy, Boehm, J, Boerries, M, Brenner, H, Busch, H, Gigic, B, Habermann, N, Herpel, E, Klett, H, Michels, KB, Scherer, D, Schirmacher, P, Schneider, M, Schrotz-King, P, Skender, S, Toth, R, Ulrich, A, Ulrich, CM, Zielske, L   +19 more
core   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, EarlyView.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

NFATc1 Regulates PD-1 Expression upon T Cell Activation [PDF]

The Journal of Immunology, 2008
Abstract PD-1 is a transmembrane protein involved in the regulation of immunological tolerance. Multiple studies have reported an association between high levels of PD-1 expressed on T cell surfaces and exhaustion in lymphocyte populations when challenged by chronic viral infections, such as HIV.
Kenneth J, Oestreich, Hyesuk, Yoon, Rafi, Ahmed, Jeremy M, Boss   +3 more
openaire   +2 more sources

The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis

Cellular & Molecular Biology Letters, 2023
Background Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases.
Tao Yang, Renyi Hei, Xiaosong Li, Tianhua Ma, Yifen Shen, Chao Liu, Wen He, Lin Zhu, Yongchun Gu, Yanping Hu, Wenbin Wei, Yihang Shen   +11 more
doaj   +1 more source

Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis [PDF]

, 2016
Osteoarthritis (OA) is a whole joint disorder that involves cartilage degradation and periarticular bone response. Changes of cartilage and subchondral bone are associated with development and activity of osteoclasts from subchondral bone.
Feng, Shiqing, Li, Jie, Li, Xinle, Liu, Daquan, Niu, Kaijun, Yang, Jing, Yokota, Hiroki, Zhang, Ping   +7 more
core   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Nfatc1 orchestrates aging in hair follicle stem cells [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Signs of aging often first appear in our skin and hair. As animals age, hair follicles spend more time resting instead of generating hair. Here we show that this decline is rooted in age-related changes in systemic, local, and intrinsic factors, which collaborate to reduce hair follicle stem cell (HFSC) activity.
Brice E, Keyes, Jeremy P, Segal, Evan, Heller, Wen-Hui, Lien, Chiung-Ying, Chang, Xingyi, Guo, Dan S, Oristian, Deyou, Zheng, Elaine, Fuchs   +8 more
openaire   +2 more sources

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase [PDF]

, 2015
Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia.
A Agrawal, A Bondareva, A Gartland, AC Monteiro, Alison Gartland, AM Baker, AM Baker, AM Parfitt, Anette M. Høye, Ankita Agrawal, BE Bax, CP El-Haibi, DA Chan, Demelza Bird, EJ Feres-Filho, Erwin M. Schoof, Georgina Lang, Hamish Forrest, HE Barker, Holly R. Evans, Iain D. Huggins, IR Garrett, Janine T. Erler, JT Chi, JT Erler, JT Erler, L Jin, Lara Perryman, M Smid, MA Blanco, MJ van de Vijver, N Pischon, N Wang, Norain Ab Latif, PS Steeg, RE Coleman, RN Kaplan, Robin M. H. Rumney, Rune Linding, S Hiratsuka, SR Vora, Thomas R. Cox, TR Cox, WJ Boyle, Y Kang   +44 more
core   +2 more sources

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

Phospholipase Cγ1 (PLCγ1) controls osteoclast numbers via colony-stimulating factor 1 (CSF-1)-dependent diacylglycerol/β-catenin/cyclinD1 pathway [PDF]

, 2016
Phospholipases Cγ (PLCγ) 1 and 2 are a class of highly homologous enzymes modulating a variety of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).
Faccio, Roberta, Kim, Seokho, Mahajan, Sahil, Yang, Zhengfeng, Zamani, Ali   +4 more
core   +2 more sources