Results 111 to 120 of about 16,913 (200)

Circular RNA SMAD4 coordinates with m6A‐dependent IGF2BP2 to promote gallbladder cancer development

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
• circSMAD4 is upregulated in GBC and is associated with poor survival. • IGF2BP2 promotes circSMAD4 biogenesis through m6A‐dependent recognition mediated by its KH3‐KH4 domains. • circSMAD4 and IGF2BP2 reciprocally stabilize each other, forming a positive feedback loop that activates JAK2/STAT3 signalling and EMT.
Yiming Li, Yayun Xu, Yuan Zhang, Si Gao, Lili Gao, Zhiqing Yuan, Ziyi Wang, Shimei Qiu, Peipei Xu, Yuanding Liu, Zhaonan Liu, Huijie Miao, Hang Xu, Maolan Li, Rong Shao, Yingbin Liu   +15 more
wiley   +1 more source

Alpinia oxyphylla Miq.: Chemical Constituents, Neuroprotective and Metabolic Effects, and Translational Challenges—A Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Alpinia oxyphylla Miq. (AOM), a medicinal and edible resource, contains diphenylheptanoids, polysaccharides, flavonoids, terpenoids, and phenolic acids. These constituents exert multi‐target synergistic effects by modulating neuroinflammation, oxidative stress, and the PI3K/Akt pathway, thereby improving Alzheimer's disease, Parkinson's disease, and ...
Ziyan Yang, Hemei Yuan, Dengyou Nie, Jun Sheng, Titi Liu, Huanhuan Xu   +5 more
wiley   +1 more source

Ets2 Is an Activity‐Dependent Transcriptional Regulator of a Fast‐Twitch Muscle Program

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Ets2 is a transcription factor rapidly (24 h) upregulated in skeletal muscle by fast 150 Hz, but not slow 20 Hz, stimulation patterns. Ets2 selectively translocates to nuclei of slow soleus muscle when stimulated by fast‐patterned, but not slow‐patterned, activity. Ets2 binds to a consensus DNA sequence in the troponin I fast intronic enhancer (TnIFIRE)
Zaheer A. Rana, Jo C. Bruusgaard, Jens R. Wendland, Ivan Winje, Ingrid M. Egner, Irina Karavanova, Einar Eftestøl, Detlef Vullhorst, Kristian Gundersen, Andres Buonanno   +9 more
wiley   +1 more source

S100A9 Induces RANKL Expression in Osteocytes Utilizing IL‐6/sIL‐6R Combination and gp130 Signaling Pathways

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
S100A9 promotes osteocyte–macrophage crosstalk by inducing osteocyte‐derived IL‐6 and macrophage‐derived soluble IL‐6 receptor (sIL‐6R). The IL‐6/sIL‐6R complex activates gp130–JAK1–STAT3 signaling in osteocytes, enhancing RANKL expression and RANK‐mediated osteoclastogenesis.
Eijiro Sakamoto, Tetsuya Yoshimoto, Rie Kido, Mikihito Kajiya, Hiromichi Yumoto   +4 more
wiley   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Two Heterozygous Mutations in NFATC1 in a Patient with Tricuspid Atresia

PLoS ONE, 2012
Tricuspid Atresia (TA) is a rare form of congenital heart disease (CHD) with usually poor prognosis in humans. It presents as a complete absence of the right atrio-ventricular connection secured normally by the tricuspid valve. Defects in the tricuspid valve are so far not associated with any genetic locus, although mutations in numerous genes were ...
Zahi Abdul-Sater, Amin Yehya, Jean Beresian, Elie Salem, Amina Kamar, Serine Baydoun, Kamel Shibbani, Ayman Soubra, Fadi Bitar, Georges Nemer   +9 more
openaire   +4 more sources

Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma

Cancer Cell International
Background This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE ...
Hui-Jen Tsai, Kun-Huei Yeh, Chung-Wu Lin, Ming-Shiang Wu, Jyh-Ming Liou, Ping-Ning Hsu, Yi-Shin Zeng, Ming-Feng Wei, Chia-Tung Shun, Hsiu-Po Wang, Li-Tzong Chen, Ann-Lii Cheng, Sung-Hsin Kuo   +12 more
doaj   +1 more source

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Clinical and Translational Medicine
Background The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons.
Bao Sun, Jin‐Gang Yang, Zhe Wang, Zheng Wang, Wei Feng, Xing Li, Sheng‐Nan Liu, Jiang Li, Ya‐Qin Zhu, Ping Zhang, Wei Wang   +10 more
doaj   +1 more source

DSF inhibited RANKL-induced NFATc1 signaling.

, 2015
(A) DSF attenuated RANKL-induced NFATc1 protein expression. Total cell lysates were extracted from BMMs treated with rRANKL for 0, 24, 48 and 72 hrs in the presence or absence of DSF (100nM).
An Qin (172006), Nathan J. Pavlos (172028), Ming H. Zheng (197848), Sarah Rea (732989), Hua Ying (47308), Kerong Dai (387141), Tak S. Cheng (172011)   +6 more
core   +1 more source

Die Bedeutung des Transkriptionsfaktors NFATc1 für die Entwicklung, das Überleben und die Funktion von B-Lymphozyten [PDF]

, 2011
Die Transkriptionsfaktoren der NFAT-Proteinfamilie (Nuclear Factor of Activated T cells, NFATc1-4) sind an entscheidender Stelle in die Regulation des Zellzyklus, des programmierten Zelltodes und der Kanzerogenese involviert.
Deb, Jolly
core   +1 more source