Results 111 to 120 of about 15,571 (214)

Gene expression of transcription factor NFATc1 in periodontal diseases

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2011
Belibasakis GN, Emingil G, Saygan B, Turkoglu O, Atilla G, Bostanci N. Gene expression of transcription factor NFATc1 in periodontal diseases. APMIS 2011; 119: 167-172. Periodontitis is a disease of infectious aetiology that causes inflammatory destruction of the tooth-supporting tissues. Activated T cells are central to the pathogenesis of the disease,
Belibasakis, G N, Emingil, G, Saygan, B, Turkoglu, O, Atilla, G, Bostanci, N   +5 more
openaire   +5 more sources

Targeting TARDBP to Restore Colonic Barrier Integrity in Ulcerative Colitis via NFATC1 mRNA Destabilization

The Turkish Journal of Gastroenterology
Background/Aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by limited understanding of post-transcriptional mechanisms governing intestinal barrier integrity.
Yin Jiang, JingLin Gao, YaLi Huang, XingHui Song, GuangTing Li, Yuan Jiang, XiuHua Liu, DaGui Chen   +7 more
doaj   +1 more source

Multiple myeloma: A tale of deregulated transcription factors

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte, Edurne San José‐Enériz, Estíbaliz Urizar‐Compains, Paula Rodriguez‐Otero, Felipe Prósper, Xabier Agirre   +5 more
wiley   +1 more source

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

Nature Communications, 2016
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in ...
Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling, Amiya Kumar Patra   +12 more
doaj   +1 more source

TRPM2 Deficiency Attenuates Allergic Rhinitis‐Like Inflammation With Altered Ca2+‐NFAT Signaling, Treg Responses, and sIgE Production

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Background Allergic rhinitis (AR) is a prevalent chronic inflammatory condition characterized by nasal itching, sneezing, and congestion, significantly impairing patients' quality of life. Despite the availability of various therapeutic options, treatment efficacy remains suboptimal for certain patients, and long‐term use may be accompanied by
Zhenke Huang, Jianping Fan, Xinxin Shan, Juntao Su, Lixin Zhu, Lijing Peng   +5 more
wiley   +1 more source

NFATc1 and cFos cooperate to activate the Zp-V3. [PDF]

, 2018
(A) EBV-negative BJAB cells were transfected with the wildtype Zp-V3 luciferase vector, the Zp-V3-141A, or the Zp-V3 ZIIIA mutant promoter luciferase constructs, with or without plasmids expressing cFos and/or NFATc1 as indicated.
Emily R. Albright (5566292), Makoto Ohashi (104612), Jillian A. Bristol (5566289), Carrie B. Coleman (584493), Eric C. Johannsen (802956), Rosemary Rochford (427830), Paul J. Farrell (166232), Robert F. Kalejta (242232), Shannon C. Kenney (184312), James C. Romero-Masters (4112614), Reza Djavadian (2854739), Mitchell Hayes (5334887), Elizabeth A. Barlow (5566295)   +12 more
core   +1 more source

De Novo Genome Assemblies of Four Rainbow Trout Genetic Lines Reveal Structural Variants in Pursuit of a Pangenome Reference

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Rainbow trout (Oncorhynchus mykiss) exhibit extensive genomic diversity shaped by domestication, life history and geographic origin. To advance the development of a comprehensive pangenome reference, we present new de novo genome assemblies of two genetically and ecologically distinct lines: Whale Rock (WR; wild, landlocked, Central California)
Ali Ali, Geoffrey C. Waldbieser, Ramey C. Youngblood, Paul A. Wheeler, Brian E. Scheffler, Stuart Willis, Shawn R. Narum, Gary H. Thorgaard, Mohamed Salem, Yniv Palti   +9 more
wiley   +1 more source

Synergistic roles of NFATc1 and c-Jun in immunomodulation

Biochemistry and Biophysics Reports
The immune system relies on precise regulatory mechanisms, with transcription factors being central to modulating immune responses. NFATc1 and c-Jun are key transcription factors that influence both adaptive and innate immunity. This review provides a comprehensive examination of the individual and synergistic roles of NFATc1 and c-Jun in immune ...
Bo Cao, Renqian Wei
openaire   +3 more sources

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

The role of NFATc1 in proximal tubule injury and repair [PDF]

, 2008
Recovery from acute kidney injury (AKI) requires renal tubule cell regeneration. The population of cells that repair the damaged proximal tubule epithelial cells (PTC) has been proposed to be derived from an external population circulating in the blood ...
Langworthy, Melissa Marie
core