Results 111 to 120 of about 21,677 (225)

In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

Journal of Pharmacological Sciences, 2015
The mitogen activated protein kinase p38 plays a role in the receptor activator of NF-ĸB ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated the effect of p38 inhibitor doramapimod on the osteoclast differentiation ...
Seong-Hee Moon, Sik-Won Choi, Seong Hwan Kim   +2 more
doaj   +1 more source

Synovial tissue macrophages: friend or foe? [PDF]

, 2017
Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano, Kurowska-Stolarska, Mariola   +1 more
core   +2 more sources

Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry

Periodontology 2000, EarlyView.
Abstract The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated.
Nima Farshidfar, Karol Alí Apaza Alccayhuaman, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron   +6 more
wiley   +1 more source

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle [PDF]

, 2015
OBJECTIVE: Physical activity and circadian rhythms are well-established determinants of human health and disease, but the relationship between muscle activity and the circadian regulation of muscle genes is a relatively new area of research.
Abraham, Reimar, Agatea, Lisa, Ahdesm\ue4ki, Miika, Argentini, Carla, Bicciato, Silvio, Blaauw, Bert, Ciciliot, Stefano, Dyar, Kenneth A., Forcato, Mattia, Pallafacchina, Giorgia, Schiaffino, Stefano, Tagliazucchi Malagoli, Guidantonio, Tothova, Jana   +12 more
core   +2 more sources

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

Gene expression of transcription factor NFATc1 in periodontal diseases

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2011
PubMed ID ...
Belibasakis, G N, Emingil, G, Saygan, B, Turkoglu, O, Atilla, G, Bostanci, N   +5 more
openaire   +4 more sources

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Epithelial calcineurin controls microbiota-dependent intestinal tumor development. [PDF]

, 2016
Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphatase required for the activation of the nuclear factor of activated T cells (NFAT ...
Arlt, Alexander, Baines, John F, Basic, Marijana, Becker, Thomas, Bianchi, Marco E, Bleich, André, Blumberg, Richard S, Bosse, Esther, Chavakis, Triantafyllos, Egberts, Jan-Hendrik, Hampe, Jochen, Kaser, Arthur, Künzel, Sven, Luzzi, Giuseppina, Muff, Stefanie, Peuker, Kenneth, Röcken, Christoph, Schafmayer, Clemens, Schreiber, Stefan, Strigli, Anne, Ulbricht, Andrea, van den Brink, Gijs R, Wang, Jun, Zeissig, Sebastian, Zeissig, Yvonne   +24 more
core   +1 more source