Results 131 to 140 of about 21,677 (225)

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

BMC Cell Biology, 2007
Background IL-10 has a potent inhibitory effect on osteoclastogenesis. In vitro and in vivo studies confirm the importance of this cytokine in bone metabolism, for instance IL-10-deficient mice develop the hallmarks of osteoporosis.
Fox Simon W, Evans Kathryn E
doaj   +1 more source

Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma

Cancer Cell International
Background This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE ...
Hui-Jen Tsai, Kun-Huei Yeh, Chung-Wu Lin, Ming-Shiang Wu, Jyh-Ming Liou, Ping-Ning Hsu, Yi-Shin Zeng, Ming-Feng Wei, Chia-Tung Shun, Hsiu-Po Wang, Li-Tzong Chen, Ann-Lii Cheng, Sung-Hsin Kuo   +12 more
doaj   +1 more source

破骨細胞分化におけるNfatc1 isoformによる機能的差異の検討 [PDF]

, 2018
埼玉医科大学平成29年
立花 秀介
core   +1 more source

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Clinical and Translational Medicine
Background The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons.
Bao Sun, Jin‐Gang Yang, Zhe Wang, Zheng Wang, Wei Feng, Xing Li, Sheng‐Nan Liu, Jiang Li, Ya‐Qin Zhu, Ping Zhang, Wei Wang   +10 more
doaj   +1 more source

NFATc1 deficiency in B cells ameliorates atopic dermatitis

Scientific Reports
Atopic dermatitis (AD) is a common skin allergy, affecting large population worldwide. Currently, there is no cure for AD. NFATc1, a transcription factor, operates through a calcium-dependent calcineurin/calmodulin pathway to regulate target genes and is
Hidaya Abdul Kader, Syed Sabih Ur Rehman, Dhanya Saraswathiamma, Sadiya Sadiq Shiek, Antonio A. Bencomo-Hernández, Ubaid Rahman Moorakkan, Muhammad Touseef Haider, Nayla Munawar, Rabah Iratni, Edgar Serfling, Mohammad Tauqeer Alam, Khalid Muhammad   +11 more
doaj   +1 more source

Autoregulation of NFATc1 gene

, 2008
Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt. Wurden NFAT-Faktoren zunächst als T-zell-spezifische Aktivatoren von Zytokinpromotoren beschrieben, so hat sich inzwischen gezeigt, dass sie in einer Vielzahl von Geweben eine wichtige ...
openaire   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

Molekulare Signalwege der aseptischen Endoprothesenlockerung [PDF]

, 2017
Die Behandlung von immobilisierenden degenerativen und entzündlichen Gelenkerkrankungen mit der Implantation von Endoprothesen ist ein großer Erfolg und Fortschritt in der Medizin und hat stark zur Verbesserung der Lebensqualität der betroffenen ...
Drees, Philipp, Eckardt, Anke, Gay, Renate E., Gay, Steffen, Huber, Lars C.   +4 more
core  

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation [PDF]

, 2018
Fanxin Long, Hart, Ismaili, Kitagawa, Megason, Seung-Yon Lee   +5 more
core   +2 more sources