Results 131 to 140 of about 15,571 (214)

Mechanismen der NFATc1-abhängigen Regulation von Stammzelleigenschaften im Pankreaskarzinom [PDF]

, 2016
Die infauste Prognose des Pankreaskarzinoms ist vor allem dem aggressiven Wachstumsverhalten und der ausgeprägten Resistenz gegenüber konventionellen Chemotherapeutika geschuldet. Beide Charakteristika sind mit einer Entdifferenzierung des Tumors und der
Vogt, Sophia, Ellenrieder, Volker (Prof. Dr.)   +1 more
core   +1 more source

Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma

Cancer Cell International
Background This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE ...
Hui-Jen Tsai, Kun-Huei Yeh, Chung-Wu Lin, Ming-Shiang Wu, Jyh-Ming Liou, Ping-Ning Hsu, Yi-Shin Zeng, Ming-Feng Wei, Chia-Tung Shun, Hsiu-Po Wang, Li-Tzong Chen, Ann-Lii Cheng, Sung-Hsin Kuo   +12 more
doaj   +1 more source

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Clinical and Translational Medicine
Background The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons.
Bao Sun, Jin‐Gang Yang, Zhe Wang, Zheng Wang, Wei Feng, Xing Li, Sheng‐Nan Liu, Jiang Li, Ya‐Qin Zhu, Ping Zhang, Wei Wang   +10 more
doaj   +1 more source

NFATc1 controls the T-cell-mediated allergic contact dermatitis [PDF]

Die allergische Kontaktdermatitis (ACD) zählt in Europa mit ca. 20% zu den häufigsten Erkrankungen der Haut. Nach Hautkontakt mit dem Allergen wird sie im Rahmen einer sog.
Azeem, Muhammad
core   +1 more source

Autoregulation of NFATc1 gene

, 2008
Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt. Wurden NFAT-Faktoren zunächst als T-zell-spezifische Aktivatoren von Zytokinpromotoren beschrieben, so hat sich inzwischen gezeigt, dass sie in einer Vielzahl von Geweben eine wichtige ...
openaire   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

NFATC1 Gene [PDF]

, 2020
openaire   +1 more source

NFATc1 in cardiac valve development and EPDC invasion [PDF]

, 2011
Congenital malformations are the most common cause of death in infancy in the United States. Of these birth defects, most are malformations of cardiac valvuloseptal structures and a significant number are coronary vessel malformations.
Combs, Michelle D.
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Epigenetische Repression des NFATc1 Transkriptionsfakors in menschlichen Lymphomen [PDF]

, 2005
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1.
Akimzhanov, Askar M.
core  

Die funktionelle Rolle von NFATc1 in der Kontrolle von Leben und Tod von Lymphozyten [PDF]

, 2007
In this study, murine ES cells and DT40 B cells were used in parallel to disrupt the Nfatc1 gene and to study the function of individual 6 Nfatc1 isoforms, especially the function of highly inducible NFATc1/aA.We found that the short isoform NFATc1/aA ...
Chen, Wen
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