Results 121 to 130 of about 16,913 (200)

NFATC1 promotes epicardium-derived cell invasion into myocardium

, 2011
Epicardium-derived cells (EPDCs) contribute to formation of coronary vessels and fibrous matrix of the mature heart. Nuclear factor of activated T-cells cytoplasmic 1 (NFATC1) is expressed in cells of the proepicardium (PE), epicardium and EPDCs in mouse
Katherine E. Yutzey, Alexander W. Lange, Michelle D. Combs, Caitlin M. Braitsch, Jeanne F. James   +4 more
core   +1 more source

Autoregulation of NFATc1 gene

, 2008
Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt. Wurden NFAT-Faktoren zunächst als T-zell-spezifische Aktivatoren von Zytokinpromotoren beschrieben, so hat sich inzwischen gezeigt, dass sie in einer Vielzahl von Geweben eine wichtige ...
openaire   +1 more source

NFATc1 mutants abolished the effects of DYRK1A.

, 2017
A. Nine mutant constructs of NFATc1 were co-transfected with pCMV-DYRK1A in HEK293 cells. B. HEK293 cells co-transfected with NFATc1 and nine mutant constructs of NFATc1 were treated with proteasome inhibitor lactacystin (5uM) for 24 hours after ...
Yuankai Zhang (3779878), Heng Liu (293917), Qian Sun (53880), Shuai Chen (506142), Long Chen (315739), Xiulian Sun (573264), Ketao Wang (3779881)   +6 more
core   +1 more source

NFATc1/alphaA: The other Face of NFAT Factors in Lymphocytes

, 2012
In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling, Edgar, Berberich-Siebelt, Friederike, Vaeth, Martin, Rudolf, Ronald, Avots, Andris, Klein-Hessling, Stefan   +5 more
core   +2 more sources

Effect of estradiol and NFATc1-specific siRNA on NFATc1 and MUC5AC mRNA expression in 1HAE₀ cells.

, 2014
A) Quantitative real-time PCR demonstrates 10−7 M estradiol stimulates a time-dependent increase in NFATc1 mRNA/HPRT1 expression with maximal increase at 4 h.
Shu-Fan Paul Man (588858), Don D. Sin (116489), Anthony Tam (588855), Delbert Dorscheid (588857), Samuel Wadsworth (588856)   +4 more
core   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

NFATC1 Gene [PDF]

, 2020
openaire   +1 more source

(A-C) Phosphorylation of NFATc1 on serine 259, phosphorylation of NFATc3 on serine 265, and expression of modulatory calcineurin-interacting protein 1 were similar in all four groups (P = NS vs. Control in each case).

, 2015
(D) Representative immunoblotting results for phosphorylated and total NFATc1 and NFATc3, together with expression of modulatory calcineurin-interacting protein 1.
Kouichi Shiozawa (750992), Kenji Suita (750993), Takayuki Fujita (324224), Yasutake Saeki (576297), Satoshi Okumura (324225), Yasumasa Mototani (750991), Daisuke Umeki (750990), Yoshiki Ohnuki (576298), Yoshiki Nakamura (560864)   +8 more
core   +1 more source

NFATc1 as a Therapeutic Target in Burkitt’s Lymphoma [PDF]

, 2015
Das Burkitt Lymphom (BL) ist ein sehr aggressives, aus dem Keimzentrum entsprungenes, B Zell Lymphom. Es tritt meisten in Kindern aus Äquatorialafrika auf, welche sowohl das EB-Virus als auch den Malariaerreger in sich tragen. Neben dieser endemischen Form gibt es auch eine sporadische und eine Immundefizienz-assozierte Form.
openaire  

NFATC1 wt Allele [PDF]

, 2020
openaire   +1 more source