Results 121 to 130 of about 15,571 (214)
The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts
Frontiers in Immunology, 2018 The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur +12 more
doaj +1 more source
Cell Proliferation, Volume 59, Issue 7, July 2026.Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao +11 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.ABSTRACT Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti‐inflammatory and ...
Feng Zhu +10 more
wiley +1 more source
CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway
Mediators of Inflammation, 2015 Our previous study proved that CD137-CD137L interaction can regulate the expression of NFATc1. Here, we investigated whether CD137 signaling regulates the expression of NFATc1 in mice VSMCs through TRAF6/NF-κB p65 pathway.
Jinchuan Yan +4 more
doaj +1 more source
BMC Cell Biology, 2007 Background IL-10 has a potent inhibitory effect on osteoclastogenesis. In vitro and in vivo studies confirm the importance of this cytokine in bone metabolism, for instance IL-10-deficient mice develop the hallmarks of osteoporosis.
Fox Simon W, Evans Kathryn E
doaj +1 more source
MK2 deficiency does not regulate NFATc1 colocalization. [PDF]
, 2015 (A) Representative confocal images of male dOCPlo cells treated with M-CSF (control) or M-CSF and RANKL for 30 minutes. A 3x magnified portion of p-p38 was inset (middle,left). (B) Pearson’s r correlation coefficients for NFATc1 and DAPI colocalization. (
Matthias Gaestel (131424) +3 more
core +1 more source
Two Heterozygous Mutations in NFATC1 in a Patient with Tricuspid Atresia
PLoS ONE, 2012 Tricuspid Atresia (TA) is a rare form of congenital heart disease (CHD) with usually poor prognosis in humans. It presents as a complete absence of the right atrio-ventricular connection secured normally by the tricuspid valve. Defects in the tricuspid valve are so far not associated with any genetic locus, although mutations in numerous genes were ...
Zahi Abdul-Sater +9 more
openaire +4 more sources
The expression of NFATc1 in adult rat skeletal muscle fibres [PDF]
, 2007 Although numerous studies have recently implicated the calcineurin–nuclear factor of activated T-cells (Cn–NFAT) signalling pathway in the regulation of activity-dependent fibre type switching in adult mammalian skeletal muscles, little is known about ...
Gabriel Mutungi, Mutungi, Gabriel
core +1 more source
Phospho-Sulindac Inhibits Pancreatic Cancer Growth: The Role of NFATc1 [PDF]
, 2012 While significant progress has been made in the battle against pancreatic cancer, it ranks 4th in cancer-related deaths in the U.S. Lending to the lethality of the disease is its ability to grow virtually undetected.
Murray, Onika T.
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation [PDF]
, 2020 Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled ...
Li, Xiaoxiao
core +1 more source