Results 101 to 110 of about 21,677 (225)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

, 2016
Background: Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.
A Bajayo, A Orr-Urtreger, A Yarilina, AJ Ewins, Attila Mócsai, CL Henemyre, David Győri, DE Rothem, Despoina Sykoutri, DK Williams, E Somm, EX Albuquerque, FC Macintosh, Gyula Poór, H Takayanagi, H Tanaka, H Tanaka, I Wessler, J Tam, JA Dani, Josef S. Smolen, K Kawashima, K Kliemann, K Redlich, KJ Tracey, KS Lips, Kurt Redlich, LM Koval, LM Walker, LZ Wu, M Artico, M Asagiri, M En-Nosse, M Kedmi, M Rosas-Ballina, MA Fang, MA Maanen van, MR McClung, MR Picciotto, O Herault, PC Staton, Peter Mandl, Petra Scholze, R Reitstetter, RL Papke, S Hayer, S Yuhara, SB Cohen, Sigismund Huck, Silvia Hayer, SJ Romano, Stephan Blüml, T Koga, T Negishi-Koga, T Sato, Thomas Karonitsch, V Itier, ZQ Wang   +57 more
core   +2 more sources

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling

PLOS ONE, 2016
Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of pyruvate to lactate, in RANKL-induced osteoclast differentiation is not known.
Heejin Ahn, Kyunghee Lee, Jin Man Kim, So Hyun Kwon, Seoung Hoon Lee, Soo Young Lee, Daewon Jeong   +6 more
openaire   +4 more sources

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

Immunity, Inflammation and Disease, 2020
Background We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies.
Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto   +11 more
doaj   +1 more source

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Journal of Hematology & Oncology, 2019
Background Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome.
Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. Göthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp, Andreas Burchert   +13 more
doaj   +1 more source

Melphalan modifies the bone microenvironment by enhancing osteoclast formation [PDF]

, 2017
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development.
Baldock, Brown, Choi, Cobb, Croucher, Dunstan, Gertz, Gillespie, Hamilton, Jemal, Kanagawa, Limaye, Martin, Martin, McCarty, Parfitt, Price, Quinn, Quinn Julian, Reagan, Rizzoli, Rosiñol, Schneider, Sexton, Thompson, Toyama, Zannettino   +26 more
core   +4 more sources

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Transcription factor decoy against NFATc1 in human primary osteoblasts

International Journal of Molecular Medicine, 2011
The present study describes, for the first time, the removal of the nuclear factor of activated T cells cytoplasmic 1 (NFATc1) by a decoy approach in human primary osteoblasts (hOBs). hOBs with different NFATc1 expression levels were used. The functionality of endogenous NFAT proteins in our experimental model was analyzed by monitoring the ...
PENOLAZZI, Maria Letizia, Lisignoli G, LAMBERTINI, Elisabetta, TORREGGIANI, Elena, Manferdini C, LOLLI, Andrea, VECCHIATINI, Renata, Ciardo F, Gabusi E, Facchini A, GAMBARI, Roberto, PIVA, Maria Roberta   +11 more
openaire   +4 more sources