Results 101 to 110 of about 15,571 (214)

Transcriptional activity of the mutated NFATC1 proteins. [PDF]

, 2013
A- Wt NFATC1 or NFATC1 Mutants (P66L, I701L, P66L/I701L) were cotransfected with the human CCND1 promoter coupled luciferase reporter construct in the presence or absence of activated clacineurin (PPP3CA) in Hela cells. Six hours post transfection, media
Fadi Bitar (295982), Amin Yehya (295970), Ayman Soubra (295980), Serine Baydoun (295978), Georges Nemer (295984), Zahi Abdul-Sater (295968), Jean Beresian (295972), Kamel Shibbani (295979), Elie Salem (295974), Amina Kamar (295977)   +9 more
core   +1 more source

Analysis of NFATc1 gene expression using eGFP-BAC reporter mice [PDF]

, 2013
In Lymphozyten wird nach Antigenaktivierung die Expression des Nfatc1-Gens durch Aktivierung des P1-Promoters stark induziert. Dagegen ist die, durch den Promoter P2 vermittelte Expression ebenso wie die der anderen NFAT Faktoren c2 und c3 konstitutiv ...
Hock, Matthias
core  

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, Volume 159, Issue 5, Page 1296-1310, 1 September 2026.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis [PDF]

, 2005
NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system.
Takayanagi, Hiroshi, Sae Ochi, Serfling, Edgar, Takako Usami, Nishina, Hiroshi, Sato, Kojiro, Tak W. Mak, Edgar Serfling, Hiroshi Takayanagi, Morita, Ikuo, Hiroshi Nishina, Kojiro Sato, Ochi, Sae, Hiroki Yoshida, Yoshida, Hiroki, Usami, Takako, Erwin F. Wagner, Mak, Tak W., Wagner, Erwin F., Ikuo Morita, Masataka Asagiri, Asagiri, Masataka   +21 more
core   +1 more source

In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

Journal of Pharmacological Sciences, 2015
The mitogen activated protein kinase p38 plays a role in the receptor activator of NF-ĸB ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated the effect of p38 inhibitor doramapimod on the osteoclast differentiation ...
Seong-Hee Moon, Sik-Won Choi, Seong Hwan Kim   +2 more
doaj   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Journal of Hematology & Oncology, 2019
Background Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome.
Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. Göthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp, Andreas Burchert   +13 more
doaj   +1 more source

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Maximilian Fröhlich, Tamara Radišković, Valentina Hopl, Magdalena Prantl, Hadil Najjar, Selina Harant, Diana Thallinger, Muhammad Shehzad Anwar, Ferdinand Horvath, Julia Söllner, Yuliia Nazarenko, Matthias Sallinger, Nora Müller, Adéla Tiffner, Sarah Weiß, Herwig Grabmayr, Heinrich Krobath, Isabella Derler   +17 more
wiley   +1 more source

NFATC1 and PAX pathway in cardiac and ocular diseases - [PDF]

, 2015
Thesis. M.Sc. American University of Beirut. Department of Biochemistry and Molecular Genetics. Faculty of Medicine 2015. W 4 P762n 2015Advisor: Dr. Georges Nemer, Professor, Department of Biochemistry and Molecular Genetics.
Poladian, Sarin Nazar,
core  

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source