Results 101 to 110 of about 13,264 (178)

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Clinical and Translational Medicine
Background The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons.
Bao Sun, Jin‐Gang Yang, Zhe Wang, Zheng Wang, Wei Feng, Xing Li, Sheng‐Nan Liu, Jiang Li, Ya‐Qin Zhu, Ping Zhang, Wei Wang   +10 more
doaj   +1 more source

Autoregulation of NFATc1 gene

, 2008
Die Familie der NFAT-Transkriptionsfaktoren (NFATc1-c4) ist im Zuge einer Immunreaktion endscheidend an der transkriptionellen Regulation der Genexpression beteiligt. Wurden NFAT-Faktoren zunächst als T-zell-spezifische Aktivatoren von Zytokinpromotoren beschrieben, so hat sich inzwischen gezeigt, dass sie in einer Vielzahl von Geweben eine wichtige ...
openaire   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

NFATC1 Gene [PDF]

, 2020
openaire   +1 more source

NFATc1 as a Therapeutic Target in Burkitt’s Lymphoma [PDF]

, 2015
Das Burkitt Lymphom (BL) ist ein sehr aggressives, aus dem Keimzentrum entsprungenes, B Zell Lymphom. Es tritt meisten in Kindern aus Äquatorialafrika auf, welche sowohl das EB-Virus als auch den Malariaerreger in sich tragen. Neben dieser endemischen Form gibt es auch eine sporadische und eine Immundefizienz-assozierte Form.
openaire  

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

NFATC1 wt Allele [PDF]

, 2020
openaire   +1 more source

NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy. [PDF]

Stem Cell Reports
Li F, Yu C, Yao L, Tang Y, Yang X, Wang Y, Liu J, Yin B, Wang H, Yu F.   +9 more
europepmc   +1 more source

Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis. [PDF]

Signal Transduct Target Ther
Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanjiv K, Chemin K, Wermeling F, Henriksson M, Slipicevic A, Jakobsson PJ, Chatzidionysiou K, Helleday T.   +16 more
europepmc   +1 more source

Conserved noncoding sequence-9 regulates NFATc1-mediated IL-10 expression in B cells to control inflammatory responses. [PDF]

Sci Adv
Kim SW, Noh J, Park HE, So KH, Hwang W, Kim GC, Kim CJ, So JS, Im SH.   +8 more
europepmc   +1 more source