Results 41 to 50 of about 15,571 (214)
NFATc1 regulates lymphatic endothelial development
Mechanisms of Development, 2009 NFATc1 transcription factor is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis and osteoclastogenesis. We identified a role for calcineurin-NFAT signaling in lymphatic development and patterning. NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial ...
Kulkarni, Rishikesh M. +2 more
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Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity
Journal of Experimental Medicine, 2020 Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its role in
Yin Xiao +16 more
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Atypical behavior of NFATc1 in cultured intercostal myofibers [PDF]
Skeletal Muscle, 2014 Abstract Background The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control the fiber type in response to muscle activity.
Robison, Patrick +2 more
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The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis [PDF]
International Journal of Molecular Sciences, 2020 The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation.
Jung Yun Kang +4 more
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DNA binding affinity of the mutated NFATC1 proteins. [PDF]
, 2013 A- NFATC1 extracts from HEK 293 cells transfected with Wt NFATC1 and Mutants (P66L – I701L – P66L/I701L) were resolved on an SDS-PAGE prior to gel shift assays.
Fadi Bitar (295982) +9 more
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Solution Structure of the Core NFATC1/DNA Complex [PDF]
Cell, 1998 The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
Zhou, Pei +4 more
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Die Bedeutung des Transkriptionsfaktors NFATc1 für frühe Differenzierungsprozesse der Thymozytenreifung [PDF]
, 2022 T lymphocytes (T cells) represent one of the major cell populations of the immune system. Named by the place of their development, the thymus, several types can be distinguished as the αβ T cells, the γδ T cells, the mucosa-associated invariant T cells ...
Giampaolo, Sabrina
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OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice. [PDF]
PLoS ONE, 2013 BACKGROUND: Our previous studies have shown that OX40-OX40L interaction regulates the expression of nuclear factor of activated T cells c1(NFATc1) in ApoE(-/-) mice during atherogenesis.
Jinchuan Yan +3 more
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Transcription factor decoy against NFATc1 in human primary osteoblasts. [PDF]
, 2011 The present study describes, for the first time, the removal of the nuclear factor of activated T cells cytoplasmic 1 (NFATc1) by a decoy approach in human primary osteoblasts (hOBs). hOBs with different NFATc1 expression levels were used.
LAMBERTINI, Elisabetta +23 more
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Drug Design, Development and Therapy, 2020 Jiaxuan Peng,1,* Kangxian Zhao,2,* Jiling Zhu,3,* Yanben Wang,4,5 Peng Sun,2 Qichang Yang,2 Tan Zhang,4 Weiqi Han,4 Wenjun Hu,4 Wanlei Yang,4 Jianwei Ruan,6 Yu Qian1,2,4 1Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University ...
Peng J +11 more
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