Results 41 to 50 of about 16,913 (200)
Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation [PDF]
, 2020 Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled ...
Li, Xiaoxiao
core +3 more sources
Solution Structure of the Core NFATC1/DNA Complex [PDF]
Cell, 1998 The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
Zhou, Pei +4 more
openaire +2 more sources
Sumolierung moduliert die NFATc1-vermittele Lymphokin Genexpression
, 2007 Die Aktivität von Transkriptionsfaktoren kann durch die Modifikation mit SUMO positiv oder negativ beeinflusst werden, indem Protein-Protein-Interaktionen als auch die subzelluläre bzw. subnukleäre Lokalisation verändert werden.
Nayak, Arnab
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OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice. [PDF]
PLoS ONE, 2013 BACKGROUND: Our previous studies have shown that OX40-OX40L interaction regulates the expression of nuclear factor of activated T cells c1(NFATc1) in ApoE(-/-) mice during atherogenesis.
Jinchuan Yan +3 more
doaj +1 more source
Fehlende NFATc1-SUMOylierung verhindert Autoimmunität und Alloreaktivität
, 2023 SUMOylation, as a post-translational modification, plays a crucial role in several biological processes. Small ubiquitin-like modifier (SUMO) proteins can be reversibly linked to the lysine residues located within specific motifs on numerous target ...
Xiao, Yin
core +1 more source
Drug Design, Development and Therapy, 2020 Jiaxuan Peng,1,* Kangxian Zhao,2,* Jiling Zhu,3,* Yanben Wang,4,5 Peng Sun,2 Qichang Yang,2 Tan Zhang,4 Weiqi Han,4 Wenjun Hu,4 Wanlei Yang,4 Jianwei Ruan,6 Yu Qian1,2,4 1Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University ...
Peng J +11 more
doaj
Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis
International Archives of Otorhinolaryngology, 2016 Introduction The structural changes underlying permanent noise-induced hearing loss (NIHL) include loss of the sensory hair cells, damage to their stereocilia, and supporting tissues within the cochlear lateral wall.
Tengku Siti Hajar Haryuna +5 more
doaj +1 more source
iScience, 2022 Summary: The Mammary gland undergoes complicated epithelial remodeling to form lobuloalveoli during pregnancy, in which basal epithelial cells remarkably increase to form a basket-like architecture. However, it remains largely unknown how dormant mammary
Ruiqi Liu +11 more
doaj +1 more source
Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways. [PDF]
PLoS ONE, 2014 Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated.
Teruhito Yamashita +7 more
doaj +1 more source
Transkriptionelle Regulation von und durch NFATc1 in Lymphozyten
, 2013 The transcription factor NFATc1 has been shown to regulate the activation and differentiation of T-cells and B-cells, of DCs and megakaryocytes. Dysregulation of NFAT signaling was shown to be associated with the generation of autoimmune diseases ...
Rudolf, Ronald
core +2 more sources