Results 131 to 140 of about 100,119 (298)

Differences in predominant collagen fiber orientation between dorsal and plantar trabecular bone tracts of adult mule deer calcanei suggest strain‐mode‐specific adaptation

The Anatomical Record, EarlyView.
Polarized microscopic images of the outer bone cortex (a and b) and deeper trabecular bone (c and d) of the deer calcaneus in thin cross‐sections. The brighter gray levels reflect more oblique‐to‐transverse collagen fibers in the compression/dorsal bone (a, c) and the darker gray levels reflect more longitudinal collagen in the tension/plantar bone (b,
John G. Skedros, John T. Cronin, Chad S. Mears, Brett W. Richards   +3 more
wiley   +1 more source

Osteoclast apoptosis during RANKL—induced differentiation.

, 2015
(A) Representative images of TRAP staining from female (top) and male (bottom) on days 5 and 7 of osteoclast culture (B) Osteoclast enumeration on days 5 and 7 from female (left) and male (right) dOCPlo cells.
Matthias Gaestel (131424), Michael S. Valerio (735366), Bethany A. Herbert (735365), Keith L. Kirkwood (307242)   +3 more
core   +1 more source

Integrated microanatomy and microstructure of the maxillary tooth plate reveal a reinforced feeding system and tougher diet in Late Triassic Hyperodapedontinae (Rhynchosauria, Archosauromorpha)

The Anatomical Record, EarlyView.
Abstract Hyperodapedontine rhynchosaurs possessed a unique oral apparatus, long interpreted as an adaptation for processing abrasive and resistant plant material. However, the microanatomical and histological evidence supporting this interpretation remains poorly documented.
Caio A. Scartezini, Pedro L. B. Pruciano, Brodsky D. M. Farias, Marina B. Soares   +3 more
wiley   +1 more source

In silico exploration of osteoclast precursor inhibition for preventing rapid bone loss after denosumab discontinuation

npj Systems Biology and Applications
Denosumab is a potent anti-resorptive drug for osteoporosis treatment that increases bone mass and reduces fracture risk. However, its discontinuation causes a rebound phenomenon where bone is rapidly lost by activated resorption, possibly because of the
Young Kwan Kim, Yoshitaka Kameo, Sakae Tanaka, Taiji Adachi   +3 more
doaj   +1 more source

Osteoclast formation and function in pigmented villonodular synovitis.

, 2011
Pigmented villonodular synovitis (PVNS) is a synovial tumour-like lesion that frequently causes osteolysis. PVNS contains numerous macrophages and osteoclast-like giant cells.
Helen Knowles, Duncan Whitwell, C L Max H Gibbons, Nicholas A Athanasou, Richard Taylor, Takesh G Kashima   +5 more
core   +1 more source

Cortical bone geometry and static gravitational loads in neosauropod dinosaurs: Implications for biomechanical constraints on terrestrial gigantism

The Anatomical Record, EarlyView.
Abstract Sauropod dinosaurs achieved unprecedented terrestrial gigantism, raising questions about the biomechanical limits of bone under extreme gravitational loads. We estimated static gravitational pressures (Pg) on appendicular cortical bone in neosauropods, including diplodocoids, brachiosaurids, and titanosaurs.
Tito Aureliano, Aline M. Ghilardi, Holly N. Woodward, Horácio W. L. Alves, Guilherme M. Sipahi   +4 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Human osteoclast ontogeny and pathological bone resorption. [PDF]

, 1999
Monocytes and macrophages are capable of degrading both the mineral and organic components of bone and are known to secrete local factors which stimulate host osteoclastic bone resorption.
Athanasou, N.A., Sabokbar, A.
core  

Synchronized Cell Cycle Arrest Promotes Osteoclast Differentiation

, 2016
Osteoclast progenitors undergo cell cycle arrest before differentiation into osteoclasts, induced by exposure to macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL).
Jin-Man Kim, Kyunghee Lee, Hyun-Sook Lim, Daewon Jeong, Minsuk Kwon, Taesoo Kim, So-Young Park   +6 more
core   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source