Results 101 to 110 of about 52,306 (137)

Identification of crucial genes for polycystic ovary syndrome and atherosclerosis through comprehensive bioinformatics analysis and machine learning

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases in patients with PCOS.
Lirong Wang, Yanli Zhang, Fan Ji, Zhenmin Si, Chengdong Liu, Xiaoke Wu, Chichiu Wang, Hui Chang   +7 more
wiley   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides

Interdisciplinary Medicine, EarlyView.
Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi, Zelin Zheng, Wen Wang, Honggang Hu   +3 more
wiley   +1 more source

Bone‐targeted hybrid extracellular vesicles for alveolar bone regeneration

Interdisciplinary Medicine, EarlyView.
Prolonged tooth loss causes a blade‐like narrowing of the alveolar bone, severely impairing chewing function and aesthetics and complicating subsequent orthodontic or restorative treatments. Bone morphogenetic protein‐2 (BMP‐2) can induce bone formation, but may cause many side effects in vivo due to insufficient cell targeting.
Anqi Liu, Gang Yang, Yijie Zhao, Jiajia Deng, Jialiang Liu, Kairun Zhang, Li Mei, Yan Liu, Tingjiao Liu   +8 more
wiley   +1 more source

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, EarlyView.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

Chinese herbal medicine‐derived extracellular vesicle‐like particles: Therapeutic potential and future research approaches

Interdisciplinary Medicine, EarlyView.
This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao, Zheng‐ting Wu, Qi You, Yuan‐yuan Xia, Qing Zhao, Carine de Marcos Lousa, Ke‐wei Zhao   +6 more
wiley   +1 more source

Morphologic and Histologic Assessment of Porcine Model of Legg−Calvé−Perthes Disease at a Clinically Relevant Time Point

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Previous studies using the porcine model of Legg−Calvé−Perthes Disease (LCPD) focused on treatments initiated 1 week following osteonecrosis (ON) induction, which represents the early avascular necrosis (AVN) stage (Stage Ia). Most patients, however, present to the clinic during later stages, like the late AVN (Stage Ib) or the early ...
Phillip Taboada, Daniel Trautmann, Garrett Croley, Joonoh Lee, Zhuo Deng, Harry K. W. Kim   +5 more
wiley   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

Peri‐implant inflammation increases the risk of osteonecrosis in mice treated with bisphosphonate

Journal of Periodontology, EarlyView.
Abstract Background Bisphosphonates (BPs) are effective in managing bone diseases due to their anti‐resorptive properties but are linked to medication‐related osteonecrosis of the jaw (MRONJ), particularly concerning dental implants. This study explored the combined impact of ligature‐induced peri‐implant inflammation and zoledronic acid (ZA), a BP ...
Ana Bujila, Davi N. A. Silva, Sepehr Monajemzadeh, Taciane M. da Silveira, Naseim Elzakra, Maísa Casarin, Kimberly Flores, Clara Magyar, Julie Marchesan, Reuben Kim, Sotirios Tetradis, Flavia Q. Pirih   +11 more
wiley   +1 more source

GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic‐associated steatotic liver disease (MASLD) encompasses common comorbidities including low bone mineral density (BMD) and hyperuricemia (HU), yet relevant genetic analyses are limited. This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low BMD in patients with MASLD ...
Tzu‐Hao Li, Yu‐Shin Huang, Chia‐Chen Ma, Shin‐Yu Tsai, Hung‐Cheng Tsai, Hsiao‐Yun Yeh, Hsiao‐Chin Shen, Shiao‐Ya Hong, Chien‐Wei Su, Hwai‐I Yang, Ying‐Ying Yang, Ming‐Chih Hou   +11 more
wiley   +1 more source