Results 111 to 120 of about 52,306 (137)

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

Nanofiber‐Coated CF/PEEK Composite: Boosting Osteogenesis for Enhanced Bone Grafting

Macromolecular Materials and Engineering, EarlyView.
Carbon‐fiber‐reinforced polyetheretherketone (CF/PEEK) with micro‐/nano‐topographical structures on its surface is obtained by electrospinning hydrophilic fibers incorporating hydroxyapatite and gelatin onto 3D‐printed CF/PEEK. This composite material promotes a significant increase in osteoblast mineralizing potential compared to non‐coated implants ...
Dan‐Lei Yang, Louise A. Stephen, Junaid Ahmad Qayyum, Dongmin Yang, Colin Farquharson, Norbert Radacsi   +5 more
wiley   +1 more source

Associations Between Lipids and Lipid‐Lowering Drug Target Genes and Osteomyelitis: A Mendelian Randomization Analysis

Medicine Advances, EarlyView.
In this study, we identified several SNPs in PCSK9 as genetic tools to comprehensively assess the influential role of PCSK9 in CHD, CRP, and osteomyelitis. PCSK9 is associated with a lower risk of osteomyelitis, and PCSK9 is also associated with a reduction in CRP concentrations. Our study supports the notion that WC may be a potential mediator between
Zhiyi Zhou, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Wanzhe Liao, Yahan Li, Linghui Liu, Ziyuan Lu   +8 more
wiley   +1 more source

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization

The Journal of Pathology, EarlyView.
Abstract Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a
Antonio Pea, Michele Bevere, Anastasios Gkountakos, Davide Pasini, Denise Fiorini, Andrea Mafficini, Stela Golovco, Michele Simbolo, Serena Pedron, Concetta Sciammarella, Paola Mattiolo, Aldo Mombello, Manuela Villanova, Carlotta Franzina, Francesca Masetto, Calogero Ciulla, Nicola Sperandio, Kohei Fujikura, Masha S. Ahadi, Jaswinder S. Samra, Amber L. Johns, Joanne Verheij, Martijn W.J. Stommel, Hjalmar van Santvoort, Leonor Schubert Santana, Giuseppe Malleo, Michele Milella, Lodewijk A. A. Brosens, Laura D. Wood, David K. Chang, Riccardo De Robertis, Mirko D'Onofrio, Anthony J. Gill, Roberto Salvia, Vincenzo Corbo, Rita T. Lawlor, Aldo Scarpa, Claudio Luchini   +37 more
wiley   +1 more source

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Phytochemical Analysis, EarlyView.
Abstract Introduction Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low‐toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic.
Sibel Kaymak, Ozan Baris Kurtur, Bahar Gok, Yasemin Budama‐Kilinc, Serda Kecel‐Gunduz, Ebru Özdemir Nath, Murat Kartal   +6 more
wiley   +1 more source

Massive Infiltrative Osteolysis of the Mandible in Oral Squamous Cell Carcinoma: A Case Report with a Review of the Literature

Precision Radiation Oncology, EarlyView.
Abstract Oral Squamous Cell Carcinoma (OSCC) is the most prevalent form of oral cancer, constituting over 90% of reported cases. This malignancy commonly infiltrates bone, making bone invasion a significant clinical issue. OSCC may invade bone via either an infiltrative or erosive pattern, with the pattern of invasion closely correlating with the ...
Smrithy Sivadas K, Ananya Madiyal, Vidya Ajila, Krishna Sharan, Yashika Jain   +4 more
wiley   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway

FASEB BioAdvances, EarlyView.
We constructed a COMMD10 knockdown model in endothelial cells and determined the influence of COMMD10 on angiogenesis and osteogenesis. The Rap1 signaling pathway is activated under low COMMD10 conditions and further enhances vascular formation and secreting pro‐osteogenic factors. Double knockdown of RAP1B and COMMD10 attenuated the angiogenic ability
Peiran Li, Yanxi Li
wiley   +1 more source

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

FASEB BioAdvances, EarlyView.
NPC1L1 Inhibits Osteogenesis via the C/EBPα/Cyp27a1/27‐OHC Axis in Osteoporosis Mechanism: ○NPC1L1 expression decreases during osteogenic differentiation. ○NPC1L1 knockdown enhances osteoblast differentiation, proliferation, and migration. ○NPC1L1 promotes cholesterol metabolism (independent of transport function), elevating Cyp27a1‐dependent 27 ...
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
wiley   +1 more source

Cochlear Cell Atlas of Two Laryngeal Echolocating Bats—New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat

Molecular Ecology Resources, EarlyView.
ABSTRACT Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high‐frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis
Xue Wang, Mingyue Bao, Hui Wang, Ruyi Sun, Wentao Dai, Keping Sun, Yue Zhu, Yingting Pu, Yujia Chu, Xintong Li, Tianhui Wang, Minjie Zhang, Aiqing Lin, Jiqian Li, Jiang Feng   +14 more
wiley   +1 more source