Results 161 to 170 of about 114,286 (188)

The Origin of the Osteoclast

Clinical Orthopaedics and Related Research, 1979
The origin of the osteoclast remains controversial even though investigations using light microscopy, tissue culture, electron microscopy, microcinematography, autoradiography, parabiosis, quail chick nuclear markers, giant lysosomal markers in beige mice, Y chromosomes, bone marrow cell culture, and monoclonal antibodies have been performed since its ...
Hiroo Yabe, Hiroshi Bun, Hideya Hanaoka
openaire   +4 more sources

Cathepsins in the osteoclast

Journal of Electron Microscopy, 2003
The mechanism by which bone collagen and other organic components are degraded by the osteoclast during osteoclastic bone resorption was unclear until the 1980s. Studies conducted since the early 1990s have identified lysosomal proteases, mainly cathepsins that are active at low pH, involved in osteoclastic bone resorption.
Teruo Tanaka   +2 more
openaire   +2 more sources

The origins of osteoclasts

Current Opinion in Rheumatology, 2004
It is now dogma that osteoclasts (OCs) arise from cells of the monocyte/macrophage lineage. However, data are accumulating suggesting that a relationship exists between B lymphocytes (B cells) and OC differentiation. Although the exact nature of this relation is unknown, it takes at least two forms.
Mark C. Horowitz, Joseph A. Lorenzo
openaire   +3 more sources

Transfection of Osteoclasts and Osteoclast Precursors

2011
Osteoclasts and their precursors have traditionally been considered difficult cells to transfect using standard approaches. Here, we describe several methods for transfection of mature osteoclasts and their precursors using the Amaxa™ Nucleofector system, lentiviruses, and adenoviruses.
David Mellis   +2 more
openaire   +3 more sources

Histogenesis of Osteoclasts

Journal of Dental Research, 1966
SYNOPSIS IN INTERLINGUA HISTOGENESE DE OSTEOCLASTAS.— Rattos blanc esseva subjicite a duo injectiones de 200 unitates de Parathormon con un intervallo de 12 horas. Tres horas post le prime injection, thymidina a tritium esseva administrate. Autoradiogrammas del maxillas esseva preparate ab specimens colligite inter hora 6 e hora 72 a partir del ...
Patrick D. Toto, John J. Magon
openaire   +3 more sources

Glucocorticoids and the Osteoclast

Annals of the New York Academy of Sciences, 2007
Abstract:  Glucocorticoid (GC)‐induced bone loss is the most common cause of secondary osteoporosis but its pathogenesis is controversial. GCs clearly suppress bone formation in vivo but the means by which they impact osteoblasts is unclear. Because bone remodeling is characterized by tethering of the activities of the two cells, the osteoclast is a ...
Haibo Zhao   +7 more
openaire   +2 more sources

THE OSTEOCLAST

Biological Reviews, 1949
SummaryOsteoclasts, Kölliker's universal agent of bone destruction, must still be regarded as enigmatical structures. It is likely that their life span is limited to a few days. Regarded by some as resulting from fusion of relatively immobile individuals of connective tissue type, and by others of mobile cells such as macrophages, it seems a ...
openaire   +3 more sources

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