Results 171 to 180 of about 100,119 (298)

Runt-related transcription factor 2 transcriptionally represses sirtuin 1 to regulate osteoclastogenesis and tooth eruption. [PDF]

J Dent Sci
Li J, Yan C, Sun X, Zhang C, Wang X, Liu Y, Zheng S.   +6 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

1α,25-(OH)2-D3 promotes osteoclast-precursor autophagy and osteoclast differentiation by promoting BECN1 transcription. [PDF]

Genet Mol Biol
Li X, Liu H, Zhu Y.
europepmc   +1 more source

Peri‐implant disease pathogenesis animal models: Consensus report of Workgroup 1 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis, Leonardo Mancini, Panos Afouxenides, Andrea Roccuzzo, IADR IRG Peri‐implantitis Best Evidence Consensus Working Group 1, Tara Aghaloo, Georgios Belibasakis, Nagihan Bostanci, Li Dehua, Nikolaos Donos, Alpdogan Kantarci, Alireza Moshaverinia, Flavia Pirih, Mia Rakic, Frank Schwarz, Sukirth Ganesan   +15 more
wiley   +1 more source

Comparative Pharmacological Effects of Tetracycline Derivatives on Osteoclast- and Osteoblast-Related Phenotypes and Skeletal Accumulation. [PDF]

Pharmaceuticals (Basel)
Shimochi S, Hrovat K, Sarwar U, Bergara-Muguruza L, Alho A, Laine M, Otaka A, Iwasaki Y, Paatero I, Gursoy UK, Mäkelä K, Savontaus E, Salonen J, Nakamura M.   +13 more
europepmc   +1 more source

Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment

Journal of Periodontology, EarlyView.
Abstract Background Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently ...
Nicholas Mazzara, Kesley Martin, Rana Dabaja, Justin Redmond, Victoria Maglaras, Maxwell Mianecki, Harout Ashekian, Joseph T. Decker, Ann M. Decker   +8 more
wiley   +1 more source

Metabolic reprogramming in macrophages: the central role of lipid metabolism in bone homeostasis. [PDF]

Bone Res
Li L, Zhang Y, Huang S, Xiao Y, Liu G, Wu Z, Hu Y, Gong S, Mao J, Song K, Li Q.   +10 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Reprogramming bone homeostasis: The recoupling-oriented framework of bidirectional regulation strategies for osteoporosis. [PDF]

iScience
Niu J, Li Z, Zou Y, Wang Z, Kang J, Zhang Y, Wang S, Liu R, Han X.   +8 more
europepmc   +1 more source

Effect of SSRIs on human osteoclast formation and function

, 2008
Effect of SSRIs on human osteoclast formation and ...
G Nicholson (9895088), Seetal Dodd (13093767), J Hodge (7836056), Lana Williams (13082460), Michael Berk (13060851)   +4 more
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