CXCL5 suppresses osteoclastogenesis and protects against lipoteichoic acid-induced bone loss by modulating PLCγ2 and c-Fos signalling in gram-positive periprosthetic joint infection. [PDF]
Bone Joint ResChang Y +5 more
europepmc +1 more source
Biochemical bone biomarkers in plasma cell dyscrasias
British Journal of Haematology, EarlyView.Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador +4 more
wiley +1 more source
Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling. [PDF]
Mol CellsKim JH +5 more
europepmc +1 more source
Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis [PDF]
, 2018 Bukowska-Straková, Karolina +8 more
core +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Translational Nanomedicine for Osteoporosis: Bridging Bone Signaling Networks and Targeted Delivery Systems. [PDF]
Int J NanomedicineLiu J, Shi S, Huang H, Wang C, Liu Y.
europepmc +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases. [PDF]
Cell DiscovZhu S, Yan MQ, Masson A, Chen W, Li YP.
europepmc +1 more source
Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology
Clinical Endocrinology, EarlyView.ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth +7 more
wiley +1 more source