Results 191 to 200 of about 141,561 (326)

Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Accepted Article.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway. [PDF]

Front Pharmacol
Wei J, Xie J, He Z, Feng X.
europepmc   +1 more source

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation

, 2017
Yuusuke Sekiguchi, Hiroshi Mano, Sachie Nakatani, Jun Shimizu, Aya Kataoka, Kana Ogura, Yoshifumi Kimira, Midori Ebata, Masahiro Wada   +8 more
openalex   +2 more sources

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. [PDF]

, 1991
Hiroaki Kodama, M Nose, Shumpei Niida, Akira Yamasaki   +3 more
openalex   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Suppression of RANKL-Induced Osteoclast Differentiation to Alleviate Osteoporosis by Targeting PPP1R15A

, 2023
Zongbao Ding, Yan Chen, Yurong Zheng, YiYuan Wang, Wende Deng, Jiehuang Zheng, Yang Qin, Ziye Chen, Hui Jiang, Xiaojuan Li   +9 more
openalex   +1 more source

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies. [PDF]

Bone Res
de Molon RS, Vernal R, Oliveira GE, Steffens JP, Ervolino E, Theodoro LH, van den Beucken JJJP, Tetradis S.   +7 more
europepmc   +1 more source

An ultrastructural study of the distribution of microtubules in osteoclasts.

, 1984
Toshiki Sakuraoka
openalex   +1 more source

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures [PDF]

, 2014
D. P. Wornham, Mark Hajjawi, Isabel R. Orriss, Timothy R. Arnett   +3 more
openalex   +1 more source