Results 191 to 200 of about 182,622 (382)

Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts

, 1989
Antonio Malgaroli, Jacopo Meldolesi, Alberta Zallone, Anna Teti   +3 more
openalex   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

Advanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang, Yuxiao Wang, Yang Ding, Xiang Chen, Shuhan Li, Wenqi Zhou, Rui Ma, Maomao Tang, Xinyuan Shao, Zixuan Shu, Ning He, Xiaodong Ma, Jian Guo, Chengjun Peng, Shuangying Gui   +14 more
wiley   +1 more source

TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1

Cell Death and Disease
Osteoporosis (OP) is a disorder of bone remodeling caused by an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Therefore, inhibiting excessive osteoclast activity is one of the promising strategies for treating OP.
Pengfei Zhu, Huaqiang Tao, Kai Chen, Miao Chu, Qiufei Wang, Xing Yang, Jun Zhou, Huilin Yang, Dechun Geng   +8 more
doaj   +1 more source

NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects

Advanced Science, EarlyView.
A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates
Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang   +9 more
wiley   +1 more source

Osteoclast differentiation antigen.

Histology and histopathology, 1996
Osteoclasts are the primary cells which perform bone resorption. The origin of these multinucleated giant cells is the haematopoietic stem cells. The differentiation pathway of the osteoclasts has so far been well studied and the cell-lineage of these bone resorbing cells is considered to be close but not identical to the monocytes/macrophages.
Kukita, T., Kukita, A.
openaire   +2 more sources

Interfacial Coordination‐Engineered Emulgel Modulates the Osteo‐Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway‐Induced Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of HIPPE‐QU‐mediated periodontal regeneration. a) Fabrication process and microstructure of HIPPE‐QU. b) Antimicrobial and immunomodulatory HIPPE‐QU hydrogel for periodontal regeneration. HIPPE‐QU hydrogel co‐delivers HA‐Cu, GNPs, and QU, providing antimicrobial effects and reprogramming the immune microenvironment to promote ...
Hui Zhang, Xiao Huang, Rui Chen, Weimin Lin, Linke Li, Xi Peng, Xinxi Yang, Xingyu Chen, Tailin Guo, Jie Weng, Jianshu Li, Quan Yuan, Huan Tan, Mengyuan Wang   +13 more
wiley   +1 more source

The preosteoclast and its cytodifferentiation into the osteoclast: Ultrastructural and histochemical studies of rat fetal parietal bone.

, 1983
Sadakazu Ejiri
openalex   +1 more source

Magnetized Cell‐Scaffold Constructs for Bone Tissue Engineering: Advances in Fabrication and Magnetic Stimulation

Advanced Science, EarlyView.
This review highlights the synthesis and applications of magnetized cells (MCs) and magnetized scaffolds (MSs) in advancing bone tissue engineering strategies. It further demonstrates how magnetic particles (MPs) improve scaffold properties and how external magnetic fields enhance mesenchymal stem cell adhesion, proliferation, and osteogenic ...
Elio Cinar SanSegundo, Mohammad J. Mirzaali, Lidy E. Fratila‐Apachitei, Amir A. Zadpoor   +3 more
wiley   +1 more source

Osteoclast enlargement in endstage renal disease

, 1985
Michael Kaye, Steven W. Zucker, Yvan G. Leclerc, Sarah Prichard, Anthony B. Hodsman, P. E. Barre   +5 more
openalex   +1 more source