Results 251 to 260 of about 130,158 (334)

RNA Binding Protein YTHDF2 Inhibits Synovial Fibroblast Inflammation and Bone Injury in Rheumatoid Arthritis by Reducing the mRNA Stability of IL‐6R

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study examined YTHDF2's role in modulating IL‐6R signaling to regulate synovial fibroblast inflammation and bone damage in rheumatoid arthritis (RA). Synovial tissues of RA patients were collected. Human fibroblast‐like synoviocyte (FLS), MH7A cell line, was induced with TNF‐α and transfected. Cell proliferation was assessed using MTT and
Yan Zhang, Xu‐Qing Cao, Xiao‐Li Ma, Yin‐Yan Guo, Tao Zhang, Li‐Li Wu, Ya‐Shan Yang, Chun‐Fang Hao, Wei‐Li Liu, Jiang‐Tao Guo   +9 more
wiley   +1 more source

Tectorigenin Ameliorates Glucocorticoid-Induced Osteoporosis by Inhibiting the NF-κB Signal Pathway and Modulating Treg-Th17 Cell Balance. [PDF]

J Cell Mol Med
Peng P, Wong P, Lv Z, Tian J, He W, Wei Q, Mo H, He M.   +7 more
europepmc   +1 more source

Morroniside Improves Diabetic Osteoporosis via the AGE/RAGE/Wnt/β‐Catenin Signaling Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Morroniside has been shown to possess various pharmacological activities, including anti‐inflammatory and antioxidative effects. This study investigates the potential mechanisms by which morroniside ameliorates diabetic osteoporosis (DOP). In vivo experiments were conducted to evaluate biochemical parameters in rats under different treatment ...
Lu Yang, Kai Wang, Zhao‐Hui Zeng, Hai‐En Zhao, Li‐Min Bai   +4 more
wiley   +1 more source

Exercise-Mediated Skeletal Muscle-Derived IL-6 Regulates Bone Metabolism: A New Perspective on Muscle-Bone Crosstalk. [PDF]

Biomolecules
Zhu C, Ding X, Chen M, Feng J, Zou J, Zhang L.   +5 more
europepmc   +1 more source

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

Engineering Efferocytosis for Bone Regeneration

Macromolecular Bioscience, EarlyView.
The repair of bone tissue in acute and chronic injuries is a significant long‐standing clinical challenge. Biomaterials‐based interventions are well‐positioned to interrogate mechanisms of efferocytosis due to their ability to provide support and guide cellular activity.
Jacob Miszuk, Linna Zhong, Hongli Sun
wiley   +1 more source

Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis. [PDF]

Research (Wash D C)
Yuan P, Feng Z, Yang H, Xue H, Xie H, Dai Z, Wang H, Liu Y, Pan B, Song H, Ye H, Xie Z, Shi P, Sun X.   +13 more
europepmc   +1 more source

Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine

Macromolecular Bioscience, EarlyView.
This review analyses multifunctional injectable hydrogels, natural or synthetic, physically or chemically crosslinked, that deliver exosomes, stem cells, and other bioactive cues to inflamed or damaged oral tissues. We discuss their immunomodulatory, antimicrobial, angiogenic, and osteogenic capacities, highlighting advances that enable regenerative ...
Renan Dal‐Fabbro, Arwa Daghrery, Caroline Anselmi, Igor Paulino M. Soares, Alexandre Henrique dos Reis‐Prado, Pedro Henrique Chaves de Oliveira, Marco C. Bottino   +6 more
wiley   +1 more source

Correction: Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy. [PDF]

Front Immunol
Huang B, Yuan Q, Sun J, Wang C, Yang D.
europepmc   +1 more source