Results 261 to 270 of about 141,561 (326)

The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects. [PDF]

Ann Med
Wei L, Yue Q, Yang D, Miao S, Lu M, Zhang Z, Liang X, Zhang X, Zhang Y.   +8 more
europepmc   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Localized therapeutic strategy based on microRNA-21-loaded mesoporous silica nanoparticles hydrogel improves bone repair in medication-related osteonecrosis of the jaw. [PDF]

J Orthop Surg Res
Li Y, Huang S, Xing Y, Chen Z, Yu D.
europepmc   +1 more source

Supplementary Video S4 from Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer

Huijuan Fan, Zhanao Xu, Ke Yao, Bingxin Zheng, Yuan Zhang, Xuxiang Wang, Tengjiang Zhang, Xuan Li, Haitian Hu, Bin Yue, Zeping Hu, Hanqiu Zheng   +11 more
openalex   +1 more source

New Technologies Empower Hemophilic Arthropathy Treatment: Focusing on Regenerative Medicine, Molecular Targeting, and Gene Therapy

Medicine Bulletin, EarlyView.
ABSTRACT Hemophilic arthropathy (HA), a major complication of hemophilia, is a chronic osteoarthropathy driven by repeated joint bleeding. Although traditional therapies such as coagulation factor replacement, physical rehabilitation, and surgery can manage symptoms, they cannot fundamentally repair established joint damage or break the pathological ...
Lin Sun, Yingnan Wang, Leyuan Zhao, Liqiang Lu, Fushan Hou, Chuan Yin, Kun Zhang, Yongqiang Hao, Jingke Fu   +8 more
wiley   +1 more source

Immune-Guided Bone Healing: The Role of Osteoimmunity in Tissue Engineering Approaches. [PDF]

Int J Mol Sci
Munaò S, Armeli A, Bonfiglio D, Iaconis A, Calabrese G.   +4 more
europepmc   +1 more source

Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling

Pan Liu, Jiezhong Deng, Yusheng Yang, Wei Bai, Shiwu Dong, Zehua Zhang   +5 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Scaffold-Mediated Microenvironmental Modulation Targeting Osteoclasts for ONFH Niche Reprogramming. [PDF]

Research (Wash D C)
Quan H, He Y, Xiao P, Zhu Z, Zhou X, Li ZA, Lei Y, Jiang H, Huang W.   +8 more
europepmc   +1 more source