Results 251 to 260 of about 100,119 (298)
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Cathepsins in the osteoclast

Journal of Electron Microscopy, 2003
The mechanism by which bone collagen and other organic components are degraded by the osteoclast during osteoclastic bone resorption was unclear until the 1980s. Studies conducted since the early 1990s have identified lysosomal proteases, mainly cathepsins that are active at low pH, involved in osteoclastic bone resorption.
Tetsuya, Goto   +2 more
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Histogenesis of Osteoclasts

Journal of Dental Research, 1966
SYNOPSIS IN INTERLINGUA HISTOGENESE DE OSTEOCLASTAS.— Rattos blanc esseva subjicite a duo injectiones de 200 unitates de Parathormon con un intervallo de 12 horas. Tres horas post le prime injection, thymidina a tritium esseva administrate.
P D, Toto, J J, Magon
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Osteoclast radicals

Journal of Cellular Biochemistry, 1994
AbstractIn biological research, new ideas arise and quickly spread to encompass the entire field. Thus, the evolution of molecular biology has significantly changed our methods of approaching our research. A similar far‐reaching finding has been the advent of radical reactions into biology.
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The birth of the osteoclast

Annals of the New York Academy of Sciences, 2010
Thirty‐five years ago it had become clear that the osteoclast was not a bone cell but an immigrant into bone, derived from the hemopoietic system. Among hemopoietic cells, mononuclear phagocytes seemed the most likely precursors. However, for the progeny of wandering cells such as those to achieve nonrandom localization implies control by the local ...
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Long bone osteoclasts display an augmented osteoclast phenotype compared to calvarial osteoclasts

Biochemical and Biophysical Research Communications, 2010
Osteoclasts are multinucleated cells specialized in degrading bone and characterized by high expression of the enzymes tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CtsK). Recent studies show that osteoclasts exhibit phenotypic differences depending on their anatomical site of action.
Serhan, Zenger   +2 more
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Multinuclearity of Osteoclasts

Nature, 1963
THE origin and function of the multinuclear osteoclast cell are of continuing interest among contemporary investigators, and have a long history among investigations on amphibian regeneration1,2.
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Osteoclast diseases

Microscopy Research and Technique, 2003
AbstractOsteoclasts are the only cells capable of resorbing mineralised bone, dentine and cartilage. Osteoclasts act in close concert with bone forming osteoblasts to model the skeleton during embryogenesis and to remodel it during later life. A number of inherited human conditions are known that are primarily caused by a defect in osteoclasts. Most of
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The osteoclast and periodontitis

Journal of Clinical Periodontology, 1986
Abstract. The osteoclast may play an important rô le in the variable rate of osseous destruction seen in periodontitis. Current understanding of various aspects of the osteoclast may help explain this fact. This review paper will first look at two theories of cell origin of the osteoclast: the multipotential osteoprogenitor cell theory and the ...
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The Origin of the Osteoclast

Clinical Orthopaedics and Related Research, 1979
The origin of the osteoclast has long been controversial. Various approaches such as traditional light microscopy, electron microscopy, microcinephotography, autoradiography, parabiosis, quail-chick nuclear marker, etc, have been used in attempts to resolve the problem.
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Generation of Osteoclasts In Vitro, and Assay of Osteoclast Activity

2007
Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte-macrophage lineage. The authors have developed a mouse marrow culture system and a coculture system of mouse osteoblasts and hemopoietic cells, in which osteoclasts are formed in response to various osteotropic factors such as 1alpha,25-dihydroxyvitamin D3, parathyroid ...
Naoyuki, Takahashi   +3 more
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