Results 281 to 290 of about 130,158 (334)

Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens

PROTEOMICS, EarlyView.
ABSTRACT Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients’ response to commonly used therapeutic regimens.
Foteini Paradeisi, Aggeliki Tserga, Vasiliki Lygirou, Manousos Makridakis, Rafael Stroggilos, Grigoris Georgiou, George M. Spyrou, Ioannis V. Kostopoulos, Christine‐Ivy Liacos, Aikaterini Termentzi, Meletios A. Dimopoulos, Ourania Tsitsilonis, Antonia Vlahou, Efstathios Kastritis, Jerome Zoidakis   +14 more
wiley   +1 more source

TNF receptor-associated factors: promising targets of natural products for the treatment of osteoporosis. [PDF]

Front Physiol
Yang X, Zhao L, Pang Y.
europepmc   +1 more source

The effect of extracellular pH on the adherence and differentiation of isolated rat osteoclasts.

, 1998
Tomoyuki Teramoto
openalex   +2 more sources

Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2–HO‐1 Pathway

Phytotherapy Research, EarlyView.
ABSTRACT Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from Salvia miltiorrhiza, has been widely used to treat cardiovascular and cerebrovascular disorders,
Hao Qiu, Chenhui Cai, Ying Zhang, Sizhen Yang, Xu Hu, Tongwei Chu   +5 more
wiley   +1 more source

Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression. [PDF]

Int J Biol Sci
Law YY, Rengamanar H, Wu CY, Liaw CC, Ghule SS, Wu YY, Lai KY, Thuong LHH, Ho TL, Lin AY, Fong YC, Tsai CH, Tang CH.   +12 more
europepmc   +1 more source

Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice. [PDF]

Arthritis Res Ther
Fukuda Y, Shimamura M, Etani Y, Noguchi T, Kurihara T, Goshima A, Miura T, Hirao M, Ochiai N, Ju N, Sugimoto A, Kanamoto T, Nakata K, Okada S, Ebina K.   +14 more
europepmc   +1 more source

Effects of psoriatic arthritis‐targeted drugs on bone remodeling: Clinical evidence and molecular pathways

Rheumatology &Autoimmunity, EarlyView.
Mechanisms and therapeutic targets in psoriatic arthritis: balancing inflammatory bone resorption and bone formation. Abstract Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by diverse clinical manifestations. Of particular concern, osteopenia and osteoporosis are prevalent in 45.27% and 12.94% of PsA patients, respectively ...
Yingchao Sun, Cheng Xu, Mingli Ouyang, Yongmei Han   +3 more
wiley   +1 more source

Direct and indirect effects of transforming growth factor-beta on osteoclast-mediated bone remodeling using a new in vitro bone matrix model. [PDF]

JBMR Plus
Chiba-Ohkuma R, Karakida T, Yamamoto R, Yamakoshi Y.   +3 more
europepmc   +1 more source

Built‐In Electric Field Accelerates Nanotopography‐Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling

Small Science, EarlyView.
Nanotopography improves the piezoelectric properties of BaTiO3 due to decreased Young's modulus. Nanotopography‐mediated mechanical stress dominantly boosts osteogenesis and angiogenesis via Piezo2/Piezo1/Ca2+ signaling. Augmented electric stimulation improves mechanical stress‐mediated osteogenic/angiogenic enhancement via PI3K/AKT/mTOR/GSK3β‐1 ...
Jingyan Huang, Dongheng Lu, Cairong Xiao, Jiezhong Guan, Xiaoshuang Wang, Changhao Li, Peng Yu, Yan Wang   +7 more
wiley   +1 more source

Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics. [PDF]

Mater Today Bio
Guo W, Yang Z, Liu F, Song J, Yang W, Li Y, Hu W, Wang K.   +7 more
europepmc   +1 more source