Results 81 to 90 of about 182,622 (382)

When is it an osteoclast? [PDF]

Journal of Clinical Pathology, 1984
Using acid phosphatase as a marker, osteoclasts were examined from single sections of undemineralised iliac crest biopsies from patients with renal failure and from normal controls. Eighty one per cent of the cells from controls and 56% of the cells from patients with renal failure appeared to be non-nucleated or mononucleated.
openaire   +3 more sources

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats

Scientific Reports, 2023
When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that ...
Shohei Shigemi, Tadasu Sato, Mayuri Sakamoto, Takehiro Yajima, Takahiro Honda, Hiroka Tsumaki, Toru Deguchi, Hiroyuki Ichikawa, Tomohiro Fukunaga, Itaru Mizoguchi   +9 more
doaj   +1 more source

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts

Frontiers in Immunology, 2022
Osteoclasts are polykaryons formed by cell–cell fusion of highly motile progenitors of the myeloid lineage. Osteoclast activity can preserve skeletal strength and bone homeostasis.
Bettina Groetsch, Elisabeth Schachtschabel, Philipp Tripal, Benjamin Schmid, Ana-Suncana Smith, Georg Schett, Aline Bozec   +6 more
doaj   +1 more source

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

International Journal of Molecular Sciences, 2018
Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts.
Kyunghee Lee, Incheol Seo, M. Choi, Daewon Jeong   +3 more
semanticscholar   +1 more source

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]

, 2017
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S, Kim, Bo-Mi, Kim, Hae-Rim, Kim, Kyoung-Woon, Lee, Kyung-Ann, Lee, Sang-Heon   +5 more
core   +1 more source

The pathobiology of the osteoclast. [PDF]

Journal of Clinical Pathology, 1985
This article reviews recent information concerning the origin of osteoclasts and the local and systemic regulation of their activity. It appears that much of the environmental responsiveness of osteoclasts is mediated by cells of the osteoblastic lineage, which exert a major influence on the localisation, induction, stimulation, and inhibition of ...
openaire   +2 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral Science
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step.
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu   +9 more
doaj   +1 more source

Metabolic properties of the osteoclast [PDF]

Bone, 2018
Osteoclasts are defined as cells capable of excavating 3-dimensional resorption pits in bone and other mineralised tissues. They are derived from the differentiation/fusion of promonocytic precursors, and are usually large, multinucleated cells. In common with other cells from this myeloid lineage such as macrophages and dendritic cells, they are ...
Arnett, TR, Orriss, IR
openaire   +4 more sources