Results 241 to 250 of about 53,100 (272)
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PPAR-γ regulates osteoclastogenesis in mice
Nature Medicine, 2007Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Regulation of osteoclast function is central to the understanding of bone diseases such as osteoporosis, rheumatoid arthritis and osteopetrosis.
Yihong, Wan +2 more
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Determination of chitinases family during osteoclastogenesis
Bone, 2014Mammalian chitinases consisting of CHIA, CHIT1, CHI3L1, CHI3L2 and CHID1 exert important biological roles in the monocyte lineage and chronic inflammatory diseases. Pathological bone resorption is a cause of significant morbidity in diseases affecting the skeleton such as rheumatoid arthritis, osteoporosis, periodontitis and cancer metastasis.
DI ROSA, MICHELINO DANIELE ANTONIO +6 more
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[Epigenetic regulation during osteoclastogenesis].
Clinical calcium, 2012Osteoclasts are differentiated from hematopoietic stem cells and become multinucleated giant cells through cell-fusion by a number of regulators. Among such regulators, transcription factors play pivotal roles by reorganizing gene networks. Recently, epigenetic regulators like histone modifiers and chromatin remodelers have emerged to be prerequisite ...
Min Young, Youn +2 more
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[Osteoclastogenesis and bone resorption].
Nihon rinsho. Japanese journal of clinical medicine, 2009Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte-macrophage lineage cells. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of NF-kappa B ligand (RANKL), in mice induces ...
Midori, Nakamura +3 more
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Cytokines, hematopoiesis, osteoclastogenesis, and estrogens
Calcified Tissue International, 1992S C, Manolagas, R L, Jilka
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[Inflammatory cytokines for osteoclastogenesis].
Nihon rinsho. Japanese journal of clinical medicine, 2005Bone homeostasis is maintained by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Osteoclast maturation requires stimulation by RANKL on osteoblasts and various stimuli. Pro-inflammatory cytokines such as IL-1 and TNF-alpha cause an imbalance in bone metabolism by favouring bone resorption via the induction of RANKL ...
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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
Nature, 2000Hiroshi Takayanagi +2 more
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