Results 231 to 240 of about 53,100 (272)

Osteoclastogenesis on Tissue-Engineered Bone

Tissue Engineering, 2004
Bone remodeling plays an important role in bone function. To date, bone tissue-engineering research has focused primarily on bone formation from osteoblasts. This study demonstrates that osteoclastogenesis can occur on a mineralized polymer scaffold. Porcine bone marrow-derived mesenchymal stem cells (pMSCs) and hematopoietic cells were isolated from ...
Keisuke, Nakagawa, Harutsugi, Abukawa, Michael Y, Shin, Hidetomi, Terai, Maria J, Troulis, Joseph P, Vacanti   +5 more
openaire   +2 more sources

RANKL-independent modulation of osteoclastogenesis

Journal of Oral Biosciences, 2019
Osteoclasts are functional cells required for bone resorption. They are derived from hematopoietic precursors and undergo a series of differentiation and fusion steps in response to various humoral factors. Depending on the importance in osteoclastogenesis, the pathways for the differentiation of hematopoietic precursors to mature osteoclasts can be ...
Wei, Feng, Jie, Guo, Minqi, Li
openaire   +2 more sources

Halenaquinone inhibits RANKL-induced osteoclastogenesis

Bioorganic & Medicinal Chemistry Letters, 2014
Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts.
Sachiko, Tsukamoto, Tomoharu, Takeuchi, Tetsuro, Kawabata, Hikaru, Kato, Michiko, Yamakuma, Kanae, Matsuo, Ahmed H, El-Desoky, Fitje, Losung, Remy E P, Mangindaan, Nicole J, de Voogd, Yoichiro, Arata, Hideyoshi, Yokosawa   +11 more
openaire   +2 more sources

Membrane Nanotube Formation in Osteoclastogenesis

2015
Membrane tunneling nanotubes (TNTs) are unique intercellular structures, which enable rapid transport of various materials and rapid communication between cells present in a long distance. During osteoclastogenesis, mononuclear osteoclast precursors form abundant TNTs in prior to cell-cell fusion.
Toshio, Kukita, Akira, Takahashi, Jing-Qi, Zhang, Akiko, Kukita   +3 more
openaire   +2 more sources

Rho GTPase Techniques in Osteoclastogenesis

2011
Historically, in vitro culturing of primary osteoclasts involved co-culturing of mononuclear monocytes with bone marrow stromal cells, thereby providing the cytokines required for osteoclast formation and multinucleation. Since the identification and cloning of receptor activator of nuclear factor kappa B ligand (RANKL), culturing primary osteoclasts ...
Roland, Leung, Michael, Glogauer
openaire   +2 more sources

Bortezomib Inhibits Human Osteoclastogenesis.

Blood, 2006
Abstract Enhanced osteoclastogenesis in cancer-induced bone disease may be caused by intercellular interactions between tumor cells and cells of the bone marrow microenvironment. In multiple myeloma, overexpression of RANKL in the bone marrow microenvironment may lead to the activation of TRAF-signaling and in consequence to increased NF-
Orhan Sezer, Kurt Possinger, Jan Sterz, Christian Jakob, Ulrike Heider, Martin Kaiser, Maren Mieth, Claudia Fleissner, Holger Krebbel, Monica Hecht, Ivana Zavrski   +10 more
openaire   +1 more source

Neutrophil extracellular traps inhibit osteoclastogenesis

Biochemical and Biophysical Research Communications
Neutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone.
Kento Numazaki, Hiroyuki Tada, Takashi Nishioka, Eiji Nemoto, Kenji Matsushita, Itaru Mizoguchi, Shunji Sugawara   +6 more
openaire   +2 more sources

[BMP and osteoclastogenesis].

Clinical calcium, 2006
Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the ...
Midori, Nakamura, Nobuyuki, Udagawa, Yohei, Yamamoto, Hiroshi, Nakamura   +3 more
openaire   +1 more source

Macrophage migration inhibitory factor inhibits osteoclastogenesis

Bone, 2009
MIF is an important regulator of innate and adaptive immunity, which is produced by a variety of cell types including activated T cells and macrophages. We examined the effects of MIF on osteoclastogenesis in bone marrow (BM) cultures from WT and MIF-deficient (KO) mice as well as the bone mass of MIF KO mice.
Claire, Jacquin, Boguslawa, Koczon-Jaremko, Hector L, Aguila, Lin, Leng, Richard, Bucala, George A, Kuchel, Sun-Kyeong, Lee   +6 more
openaire   +2 more sources

IGF2 modulates the microenvironment for osteoclastogenesis

Biochemical and Biophysical Research Communications, 2009
We previously reported that hypoxic stress enhanced osteoclast differentiation via increasing insulin-like growth factor 2 (IGF2) production. However, the mechanisms underlying IGF2 stimulation remains unknown. In this study, we investigated the molecular mechanisms of osteoclastogenesis by IGF2 treatment.
Kimihisa, Nakao, Mineyoshi, Aoyama, Hayato, Fukuoka, Masataka, Fujita, Ken, Miyazawa, Kiyofumi, Asai, Shigemi, Goto   +6 more
openaire   +2 more sources