Results 211 to 220 of about 31,404 (249)

Role of Relaxin in Human Osteoclastogenesis

Annals of the New York Academy of Sciences, 2009
Recently, we have demonstrated that INSL3 is important for bone metabolism, and in this study we analyzed the possible role of the cognate hormone relaxin on human osteoclasts. In fact, previous studies showed an effect of relaxin on peripheral blood mononuclear cells (PBMCs), the precursors of osteoclasts.
FACCIOLLI A, FERLIN, ALBERTO, GIANESELLO, LISA, PEPE A, FORESTA, CARLO   +4 more
openaire   +3 more sources

Action of RANKL and OPG for Osteoclastogenesis

Critical Reviews™ in Eukaryotic Gene Expression, 2009
Osteoclasts develop from hematopoietic cells of the monocyte-macrophage lineage. The coculture system of osteoblasts and hematopoietic cells was devised to examine osteoclastogenesis in vitro. Experiments using the coculture system have established the concept that osteoblasts are crucially involved in osteoclastogenesis.
Yasuhiro, Kobayashi, Nobuyuki, Udagawa, Naoyuki, Takahashi   +2 more
openaire   +2 more sources

The role of the chemokine CXCL12 in osteoclastogenesis

Trends in Endocrinology & Metabolism, 2007
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the ...
Gronthos, S., Zannettino, A.
openaire   +3 more sources

Osteoclastogenesis: The Role of Calcium and Calmodulin

Critical Reviews in Eukaryotic Gene Expression, 2005
Enhanced osteoclastogenesis is an important pathological feature in several aging-associated bone diseases. Thus, research activities on osteoclastogenesis have been intense during the last ten years. There has been great progress made in this field, however, and in this review, we will focus on current advances in understanding the role of Ca2 ...
Liang, Zhang, Margaret A, McKenna, Nasser, Said-Al-Naief, Xiaojun, Wu, Xu, Feng, Jay M, McDonald   +5 more
openaire   +2 more sources

Membrane Nanotube Formation in Osteoclastogenesis

2015
Membrane tunneling nanotubes (TNTs) are unique intercellular structures, which enable rapid transport of various materials and rapid communication between cells present in a long distance. During osteoclastogenesis, mononuclear osteoclast precursors form abundant TNTs in prior to cell-cell fusion.
Toshio, Kukita, Akira, Takahashi, Jing-Qi, Zhang, Akiko, Kukita   +3 more
openaire   +2 more sources

RANKL-independent modulation of osteoclastogenesis

Journal of Oral Biosciences, 2019
Osteoclasts are functional cells required for bone resorption. They are derived from hematopoietic precursors and undergo a series of differentiation and fusion steps in response to various humoral factors. Depending on the importance in osteoclastogenesis, the pathways for the differentiation of hematopoietic precursors to mature osteoclasts can be ...
Wei, Feng, Jie, Guo, Minqi, Li
openaire   +2 more sources

[BMP and osteoclastogenesis].

Clinical calcium, 2006
Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the ...
Midori, Nakamura, Nobuyuki, Udagawa, Yohei, Yamamoto, Hiroshi, Nakamura   +3 more
openaire   +1 more source

The Negative Role of IDS in Osteoclastogenesis

2007
Osteoclasts play an important role in bone metabolism by resorbing the bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells (DCs). Two essential cytokines, macrophage colony-stimulating factor (M-CSF) and TRANCE (also called RANKL, OPGL, and ODF), enable osteoclast ...
Junwon, Lee, Seoung-Hoon, Lee, Yongwon, Choi, Nacksung, Kim   +3 more
openaire   +2 more sources

Rho GTPase Techniques in Osteoclastogenesis

2011
Historically, in vitro culturing of primary osteoclasts involved co-culturing of mononuclear monocytes with bone marrow stromal cells, thereby providing the cytokines required for osteoclast formation and multinucleation. Since the identification and cloning of receptor activator of nuclear factor kappa B ligand (RANKL), culturing primary osteoclasts ...
Roland, Leung, Michael, Glogauer
openaire   +2 more sources

S6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin

Phytomedicine
Over-activation of osteoclastogenesis is a significant factor contributing to bone loss, leading to increased resorption of bone. Columbianadin (CBN), a compound derived from Angelicae Pubescentis Radix, has traditionally been used in Chinese medicine to treat bone-related disorders.
Qiu Wei, Zi-Chang Niu, Xiao-Yu Fu, Ming-Hui OuYang, Xiao-Tong Guo, Jin Li, Yan-Xu Chang, Hao-Ping Mao, Xiu-Mei Gao   +8 more
openaire   +2 more sources