Results 201 to 210 of about 31,404 (249)

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Journal of Cellular Physiology, 2023
AbstractOsteoclasts, the bone‐resorbing cells, are essential for the bone remodeling process and are involved in the pathophysiology of several bone‐related diseases. The extensive corpus of in vitro research and crucial mouse model studies in the 1990s demonstrated the key roles of monocyte/macrophage colony‐stimulating factor, receptor activator of ...
Aleena Anwar, Leena Sapra, Navita Gupta, Rudra P. Ojha, Bhupendra Verma, Rupesh K. Srivastava   +5 more
openaire   +2 more sources

Osteoclastogenesis and arthritis

Clinical and Experimental Medicine, 2010
There is emerging interest for osteoclasts as key players in the erosive and inflammatory events leading to joint destruction in chronic arthritis. In fact, chronic inflammatory joint diseases such as psoriatic arthritis and rheumatoid arthritis are often characterized by destruction of juxta-articular bone and erosions due to the elevated activity of ...
MARUOTTI, NICOLA, CANTATORE, FRANCESCO PAOLO, Grano M, Colucci S, d'Onofrio F   +4 more
openaire   +3 more sources

Cytokine-Mediated Immunomodulation of Osteoclastogenesis

Bone, 2022
Cytokines are an important set of proteins regulating bone homeostasis. In inflammation induced bone resorption, cytokines, such as RANKL, TNF-α, M-CSF, are indispensable for the differentiation and activation of resorption-driving osteoclasts, the process we know as osteoclastogenesis.
Ting Zheng, Baohong Zhao, Pengcheng Zhou
exaly   +3 more sources

Osteoclastogenesis on Tissue-Engineered Bone

Tissue Engineering, 2004
Bone remodeling plays an important role in bone function. To date, bone tissue-engineering research has focused primarily on bone formation from osteoblasts. This study demonstrates that osteoclastogenesis can occur on a mineralized polymer scaffold. Porcine bone marrow-derived mesenchymal stem cells (pMSCs) and hematopoietic cells were isolated from ...
Keisuke, Nakagawa, Harutsugi, Abukawa, Michael Y, Shin, Hidetomi, Terai, Maria J, Troulis, Joseph P, Vacanti   +5 more
openaire   +2 more sources

The roles of interferons in osteoclasts and osteoclastogenesis

Joint Bone Spine, 2016
Interferons (IFNs) play essential roles in regulating osteoclast differentiation and bone resorption. Over the last decade, we have seen tremendous developments in our understanding of the mechanisms by which interferons regulate osteoclastogenesis. Of the type I interferons, IFN-β inhibits osteoclastogenesis via autoregulatory or exogenous regulatory ...
Qi Xiong, Lihai Zhang, Wei Ge, Peifu Tang   +3 more
openaire   +2 more sources

The use of apocynin inhibits osteoclastogenesis

Cell Biology International, 2019
AbstractReactive oxygen species (ROS) are produced by NADPH oxidase (NOX), an enzyme that reduces oxygen by using NADPH as a substrate. Apocynin (APO) is a catechol that is used as a NOX inhibitor, and N‐acetyl‐cysteine ​​(NAC) can reduce intracellular ROS levels. In this work, the effect of APO and NAC on osteoclast formation were evaluated.
Mariana Pena Ribeiro, Soares, Danielle Pereira, Silva, Isadora Akemi, Uehara, Erivan Schnaider, Ramos, Paulo Vinicius Gil, Alabarse, Sandra Yasuyo, Fukada, Felipe Cordero, da Luz, Leda Quercia, Vieira, Ana Paula Lima, Oliveira, Marcelo José Barbosa, Silva   +9 more
openaire   +2 more sources

IGF2 modulates the microenvironment for osteoclastogenesis

Biochemical and Biophysical Research Communications, 2009
We previously reported that hypoxic stress enhanced osteoclast differentiation via increasing insulin-like growth factor 2 (IGF2) production. However, the mechanisms underlying IGF2 stimulation remains unknown. In this study, we investigated the molecular mechanisms of osteoclastogenesis by IGF2 treatment.
Kimihisa, Nakao, Mineyoshi, Aoyama, Hayato, Fukuoka, Masataka, Fujita, Ken, Miyazawa, Kiyofumi, Asai, Shigemi, Goto   +6 more
openaire   +2 more sources

The role of physical forces in osteoclastogenesis

Journal of Cellular Physiology, 2019
AbstractThe movements of life at every level from organs, tissues, cells to sub‐cells, are all conducted in certain physical environments. In the human body, skeletal tissue among all connective tissues is influenced the most by physical forces. Studying the biological behavior of bone cells under different physical environments is helpful in further ...
Qinyu Ma, Zaisong Ma, Mengmeng Liang, Fei Luo, Jianzhong Xu, Ce Dou, Shiwu Dong   +6 more
openaire   +2 more sources