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Mechanotransduction in osteogenesis
Bone & Joint Research, 2020 Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a
S. Stewart +4 more
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Stem Cells International, 2021 The combination of osteogenesis and angiogenesis dual-delivery trace element-carrying bioactive scaffolds and stem cells is a promising method for bone regeneration and repair.
Zhen Tan +6 more
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FKBP5 promotes osteogenic differentiation of mesenchymal stem cells through type-I interferon pathway Inhibition [PDF]
Cellular and Molecular Life SciencesThe decreased osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is an important factor causing bone loss. Nevertheless, its deep molecular mechanism has still not been fully clarified.
Jun Tang +9 more
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Management of Osteogenesis Imperfecta [PDF]
Frontiers in Endocrinology, 2020 Osteogenesis imperfecta (OI) is the term used to describe a group of rare inherited skeletal disorders characterized by a greatly increased risk of fragility fractures (1). Mutations in several genes can cause OI but the condition is most commonly caused
S. Ralston, M. Gaston
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The Lancet, 2016 Osteogenesis imperfecta is a phenotypically and molecularly heterogeneous group of inherited connective tissue disorders that share similar skeletal abnormalities causing bone fragility and deformity. Previously, the disorder was thought to be an autosomal dominant bone dysplasia caused by defects in type I collagen, but in the past 10 years ...
A. Forlino, J. Marini
semanticscholar +4 more sources
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2006 Osteogenesis imperfecta is an inherited disorder of the connective tissue. The extreme bone fragility seen in patients suffering from osteogenesis imperfecta pose a series of problems with regard to behavior management and rendering of quality dental ...
Gupte Tejashri +4 more
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Genetic heterogeneity in osteogenesis imperfecta. [PDF]
Journal of Medical Genetics, 1979 David Sillence, A Senn, D. M. Danks
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Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes
Biology, 2021 The Fas ligand (FasL) is known from programmed cell death, the immune system, and recently also from bone homeostasis. As such, Fas signalling is a potential target of anti-osteoporotic treatment based on the induction of osteoclastic cell death.
Adela Kratochvilova +6 more
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A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
Nature, 2021 Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic stem cells and early restricted progenitors1–6.
Bo Shen +22 more
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Der Orthopäde, 2012 The classic Sillence classification of the four types of osteogenesis imperfecta (OI) has been extended by six additional forms in recent years. OI is a heterogeneous disease, which can exhibit a mild, moderate and severe clinical picture. The clinical variability is expressed by a different frequency of fracture incidences and bone deformity risks so ...
Morello, Roy, Esposito, Paul W.
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