Results 41 to 50 of about 48,007 (294)

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

open access: yesAdvanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao   +7 more
wiley   +1 more source

Osteonecrosis of the Jaw [PDF]

open access: yesJournal of Oncology Practice, 2006
This review looks at osteonecrosis in the stomatognathic system (mainly the jaws). Osteonecrosis of the jaw (ONJ) is a rare but serious clinical condition. It affects patients treated with bisphosphonates, and also with denosumab, mainly in oncological doses. In osteoporosis, it is a problem of relatively small significance. Article presents a thorough
openaire   +2 more sources

Cellular-Based Therapy for Osteonecrosis

open access: yes, 2009
This review article describes bone remodeling in the context of osteonecrosis as a bone disease, the use of stem cells in bone and vascular diseases, and cellular therapy in osteonecrosis. © 2009 Elsevier Inc. All rights reserved.SCOPUS: re.jinfo:eu-repo/
Hauzeur, J.-P.   +3 more
core   +1 more source

Management of Osteonecrosis of the Hip Complicated with Fracture: A Case Report [PDF]

open access: yes, 2012
A 47-year-old gentleman, with underlying seborrhoeic dermatitis that was treated with steroid therapy, and hepatitis B, presented with pain in his right hip.
Chiu CK, Kareem BA, Chua YCJ, Wazir NN
core   +2 more sources

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

open access: yesAGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Osteonecrosis of the Talus

open access: yes, 2014
Osteonecrosis of the talus (ONT) refers to the death of osteocytes and subsequent structural changes leading to talus collapse and secondary ankle joint osteoarthritis. ONT is a rarer disease than osteonecrosis of the femoral head (ONFH); however it is a
Kyoung Min Lee   +5 more
core   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco   +7 more
wiley   +1 more source

Emerging therapies with potential risks of medicine-related osteonecrosis of the jaw: a review of the literature

open access: yes, 2020
In the past, osteonecrosis of the jaw (ONJ) was generally reported with bisphosphonate drugs; hence, the term BRONJ (bisphosphonate-related osteonecrosis of the jaw) was initially proposed.
Bakr, Mahmoud M   +7 more
core   +1 more source

Utility of quantitative standardized uptake value from pre-operative bone SPECT/CT for predicting post-surgical MRONJ healing response

open access: yesEJNMMI Research
Background Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition often associated with long-term use of anti-resorptive medications.
Jung-Hyun Park   +3 more
doaj   +1 more source

Comparing robot-assisted and conventional surgery in knee replacement: A meta-analysis of surgical-site wound complications and recovery outcomes

open access: yesAsian Journal of Surgery
Objective: This meta-analysis aims to assess the impact of robotic and open-cut forms on postoperative complications in knee replacement surgeries. Method: A comprehensive and systematic search was conducted on four significant databases using keywords ...
Hu Liang, Yangquan Hao, Wenxing Yu
doaj   +1 more source

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