Results 41 to 50 of about 46,379 (288)

Existing hip joint disease is associated with an increased incidence of hip fracture in adults: A retrospective survey of 9710 individuals from a single center

Heliyon
Objective: In hip disease patients, pain and movement restrictions might cause changes in bone strength and increase the likelihood of falls, finally leading to hip fracture.
Bo Liu, Xiao Chen, Mengnan Li, Xiaoxuan Zhang, Binquan Zhang, Huijie Li   +5 more
doaj   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, EarlyView.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Medication-Related Osteonecrosis of the Jaws (MRONJ): Etiological Update

, 2014
Osteonecrosis of the jaws (ONJ) is an uncommon but severe bone disease, can be related to various medicaments (MRONJ) including bisphosphonates (BRONJ), antiangiogenic and antiresorptive medicaments such as Denosumab (DRONJ), human monoclonal antibody to
TENORE, GIANLUCA, ROMEO, Umberto, GAIMARI, GIANFRANCO, Gianfranco Gaimari, Orlando Brugnoletti, Mohamed Mohsen, BRUGNOLETTI, Orlando, Gianluca Tenore, BOVE, Ercole, PALAIA, GASPARE, Lino Bove, Rossella Lo Giudice, Gaspare Palaia, Umberto Romeo   +13 more
core   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw [PDF]

, 2021
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose
Carlos Navarro Cuéllar, Zamorano León, José Javier, Rodríguez Pérez, Irene, Bacián Martínez, Sandra, Navarro Vila, Carlos, Ignacio Navarro Cuéllar, Edurne Palacios Weiss, José Luis del Castillo Pardo de Vera, García-Hidalgo Alonso, María Isabel, Amo Fernández de Velasco, Álvaro del, Pujol Romanyá, Roser, Margarita Escrig de Teijeiro, Palacios Weiss, Edurne, Navarro Cuéllar, Carlos, Álvaro del Amo Fernández de Velasco, María Isabel García-Hidalgo Alonso, Sandra Bacián Martínez, José J. Zamorano-León, López Farre, Antonio José, Arturo Sánchez-Pérez, Roser Pujol Romanyá, Antonio López-Farré, Navarro Cuéllar, Ignacio, Escrig de Teijeiro, Margarita, Sánchez-Pérez, Arturo, Irene Rodríguez Pérez, Castillo Pardo de Vera, José Luis del, Carlos Navarro Vila   +27 more
core   +1 more source

Osteonecrosis of the Jaw [PDF]

Journal of Oncology Practice, 2006
This review looks at osteonecrosis in the stomatognathic system (mainly the jaws). Osteonecrosis of the jaw (ONJ) is a rare but serious clinical condition. It affects patients treated with bisphosphonates, and also with denosumab, mainly in oncological doses. In osteoporosis, it is a problem of relatively small significance. Article presents a thorough
openaire   +2 more sources

Osteonecrosis

, 2017
In this book there are chapters written by great specialists, both doctors and dentists, addressing a very important subject for clinical practice and research: osteonecrosis. In addition to a general review of the subject matter in the introduction, you

core   +1 more source

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

Hip Arthroscopy in Adults Aged 40 or Older Produces Clinically Meaningful Symptom Improvement but Carries a Substantial Risk of Conversion to Total Hip Arthroplasty: A Systematic Review

Arthroscopy, EarlyView.
Purpose To report conversion rates to total hip arthroplasty (THA), patient‐reported outcome measures, and complication rates in adults aged ≥ 40 years undergoing hip arthroscopy since 2016. Methods MEDLINE, EMBASE, and PubMed were searched from January 2016 to March 2025, and pertinent data were abstracted from eligible studies according to the ...
Helena Son, Benjamin Blackman, Joshua Dworsky‐Fried, Dan Cohen, Yoan Bourgeault‐Gagnon, Axel Öhlin, Nicole Simunovic, Iqbal Multani, Tyler M. Hauer, Craig S. Mauro, Olufemi Ayeni   +10 more
wiley   +1 more source

Knee osteonecrosis incidence from two real-world data sources

Osteoarthritis and Cartilage Open, 2021
Background: Anti-nerve growth factor (NGF) has shown promise for osteoarthritis (OA) pain efficacy, but an unanticipated joint safety signal occurred in trials.
Jean W. Liew, Seoyoung C. Kim, Christine Peloquin, David T. Felson, Yinzhu Jin, Joyce Lii, Tuhina Neogi   +6 more
doaj   +1 more source