Results 31 to 40 of about 46,379 (288)

Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis

, 2010
Bisphosphonates are the leading drugs for the treatment of osteoporosis. In ­randomized controlled trials (RCTs), alendronate, risedronate, and zoledronate have shown to reduce the risk of vertebral, nonvertebral, and hip fractures, whereas RCTs with ...
Graham Russell, Cooper, Cyrus, Ebetino, F. Hal, Cooper, C, Russell, RG, Pazianas, Michael, Ebetino, FH, Russell, R. Graham G., Pazianas, M   +8 more
core   +1 more source

iNOS expression and osteocyte apoptosis in idiopathic, non-\ud traumatic osteonecrosis [PDF]

, 2015
Background and purpose\ud \ud Non-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty.
Kalhor, Ali, Lu, Shifeier, Crawford, Ross, Xiao, Yin, Wang, Jun, Ni, Jiang-Dong   +5 more
core   +1 more source

The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis

Lipids in Health and Disease, 2018
Background The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH).
Yangquan Hao, Hao Guo, Zhaochen Xu, Handeng Qi, Yugui Wang, Chao Lu, Jie Liu, Puwei Yuan   +7 more
doaj   +1 more source

Cuidados na avaliação e atendimento odontológico em pacientes usuários de bisfosfonatos: uma revisão de literatura. [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Os bisfosfonatos são análogos estruturais do pirofosfato, que apresentam elevada afinidade pelo tecido ósseo.
Dengo, Suhéllen Vicenzi
core  

Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression [PDF]

, 2017
Johann Lechner,1 Sabine Schuett,2 Volker von Baehr2 1Clinic for Integrative Dentistry, Munich, 2Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany Abstract: Of the definitions listed in the ...
Volker von Baehr, Lechner J, Sabine Schuett, Schuett S, Johann Lechner, von Baehr V   +5 more
core   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Radiographic sclerosis with intraoperative fragile bone in skeletal fluorosis: a case report

Frontiers in Surgery
IntroductionSkeletal fluorosis is a rare toxic osteopathy characterized by massive bone fluoride fixation. The disease is an endemic problem in some parts of the world and is the result of the prolonged ingestion or inhalation of large amounts of ...
Weikun Hou, Lin Liu, Wensen Jing, Chao Lu, Yangquan Hao   +4 more
doaj   +1 more source

Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Frontiers in Bioengineering and Biotechnology, 2021
Osteonecrosis without effective early treatment eventually leads to the collapse of the articular surface and causes arthritis. For the early stages of osteonecrosis, core decompression combined with bone grafting, is a procedure worthy of attention and ...
Hengliang Dong, Tongtong Zhu, Mingran Zhang, Dapeng Wang, Xukai Wang, Guanning Huang, Shuaishuai Wang, Minglei Zhang   +7 more
doaj   +1 more source

Uso da laserterapia na osteonecrose e osteorradionecrose dos maxilares [PDF]

, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.A osteonecrose dos maxilares (ONM) pode ser dividida em dois grandes grupos: Osteonecrose relacionada com medicamentos (ONMRM) e a Osteorradionecrose (ORN).
Silva, Gabriel Xavier da
core  

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source