Results 1 to 10 of about 23,381 (306)

Alterations of bone proteins in medication‐related osteonecrosis of the jaw [PDF]

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +4 more sources

CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma [PDF]

Haematologica, 2011
Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene ...
Esperanza Such, José Cervera, Evangelos Terpos, José V Bagán, Amparo Avaria, Inés Gómez, María Margaix, Mariam Ibañez, Irene Luna, Lourdes Cordón, Mónica Roig, Miguel A. Sanz, Meletios A. Dimopoulos, Javier de la Rubia   +13 more
doaj   +3 more sources

Effect of metformin on inflammation and bone damage in a rat model of medication‐related osteonecrosis of the jaw [PDF]

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract This study investigated how chronic metformin administration modulates the cellular profile and inflammatory markers in a zoledronic acid‐based rat model of medication‐related osteonecrosis of the jaw (MRONJ). Male Wistar rats were allocated to different treatments: (i) naïve, (ii) MRONJ (zoledronic acid, 0.2 mg/kg, i.v.
Liviane Maria Alves Rabelo, Mariana Vasconcelos Guimarães, Aurilene Gomes Cajado, José Vitor Mota Lemos, Felipe Domingos de Sousa, Nylane Maria Nunes Alencar, Vilma de Lima, Paulo Goberlânio de Barros Silva, Ana Paula Negreiros Nunes Alves, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima‐Júnior   +10 more
wiley   +2 more sources

Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphpsphonates [PDF]

, 2016
Chemotherapy-associated osteonecrosis of the jaw caused by bisphosphonates is an exposure of necrotic bone with more than eight weeks of evolution that is attributable to bisphosphonates and no prior radiation therapy.
Bermúdez Bejarano, Elena Beatriz, Castillo de Oyagüe, Raquel, Gutiérrez Corrales, Aida, Gutiérrez Pérez, José Luis, Machuca Portillo, Guillermo, Romero Ruiz, Manuel María, Serrera Figallo, María Angeles, Torres-Lagares, Daniel   +7 more
core   +11 more sources

What Do Prescribers of Bone Modifying Agents Know about Medication-Related Osteonecrosis of the Jaw? Is Current Prevention Enough?

Applied Sciences, 2022
Osteonecrosis of the jaw represents interference by external and internal factors in the natural bone remodeling system. Numerous bone remodeling agents (BMAs), such as bisphosphonates, denosumab, and tyrosine kinase inhibitors, can lead to medication ...
Mihai Vlad Golu, Ionela Pașcanu, Cornelia Togănel, Cecilia Petrovan, Adina Cosarcă, Despina Luciana Bereczki Temistocle, Alina Ormenișan   +6 more
doaj   +1 more source

Prediction of medication-related osteonecrosis of the jaw (MRONJ) using automated machine learning in patients with osteoporosis associated with dental extraction and implantation: a retrospective study

Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2023
Objectives This study aimed to develop and validate machine learning (ML) models using H2O-AutoML, an automated ML program, for predicting medication-related osteonecrosis of the jaw (MRONJ) in patients with osteoporosis undergoing tooth extraction or ...
Dahui Kwack, S. Park
semanticscholar   +1 more source

Medication-related osteonecrosis of the jaw: A disease of significant importance for older patients.

Journal of The American Geriatrics Society, 2023
BACKGROUND Medication-related osteonecrosis of the jaw (MRONJ) is clinically defined as a non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with anti-resorptive, anti-angiogenic ...
Bridget Boston, D. Ipe, B. Căpitănescu, Andrei Gresita, S. Hamlet, R. Love, M. Hadjiargyrou, Chien-Ling Huang, I. Nusem, R. Miroiu, A. Popa-Wagner, P. Warnke, E. Petcu   +12 more
semanticscholar   +1 more source

Clinical significance of drug cessation on medication-related osteonecrosis of the jaw in patients with osteoporosis

Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2023
Objectives Suspending bisphosphonates (BPs) to reduce the risk and severity of medication-related osteonecrosis of the jaw (MRONJ) remains controversial. In this study, we quantitatively evaluated the clinical significance of BP suspension before surgery
Kezia Rachellea Mustakim, M. Eo, J. Lee, M. Seo, S. Kim   +4 more
semanticscholar   +1 more source

The effect of drug holiday before tooth extraction on the development of medication-related osteonecrosis of the jaw in cancer patients receiving intravenous bisphosphonates

Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2023
Objectives Drug holidays are suggested to reduce the formation of osteonecrosis in patients under intravenous (IV) bisphosphonates (BPs) therapy. The objectives of this study are to evaluate the incidence of medication-related osteonecrosis of the jaw ...
Ç. Karaca, Göknur Topaloğlu-Yasan, S. Adiloğlu, Ecem Usman   +3 more
semanticscholar   +1 more source

Association between periodontal disease, tooth extraction and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study.

The Journal of Periodontology, 2022
BACKGROUND We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which is a major risk factor for MRONJ occurrence. METHODS This retrospective,
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, Hong-Pyo Lee, Hyo-Jung Lee   +6 more
semanticscholar   +1 more source