Results 241 to 250 of about 13,217 (287)

Platelet-Rich Plasma in the Prevention and Treatment of Medication-Related Osteonecrosis of the Jaw: A Systematic Review and Meta-Analysis

The Journal of craniofacial surgery (Print)
Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a significant complication associated with bisphosphonates, impacting jaw osteoclasts, and causing altered bone remodelling.
Marwan H. Aljohani
semanticscholar   +1 more source

Factors affecting the quality of life of patients with medication-related osteonecrosis of the jaw during treatment: A quality-of-life survey and causal analysis.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
This prospective cohort study aimed to investigate the impact of medication-related osteonecrosis of the jaw (MRONJ) on health-related quality of life (HRQOL) and oral health-related QOL (OHRQOL) and the association between the downstaging of MRONJ and ...
K. Munakata, H. Miyashita, Yuka Yamada, T. Soma, R. Iwasaki, T. Nakagawa, S. Asoda   +6 more
semanticscholar   +1 more source

Osteonecrosis of the jaws and bisphosphonates

Current Osteoporosis Reports, 2008
Osteonecrosis of the jaws associated with bisphosphonate therapy was first identified in 2003 as a condition typified by exposed bone that does not heal after 8 weeks. Other signs and symptoms, such as pain and infection, may or may not be present. There is a strong need for consensus on a case definition for this condition. This condition has occurred
David G, Pendrys, Stuart L, Silverman
openaire   +2 more sources

Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw

Oral and Maxillofacial Surgery Clinics of North America, 2015
The relationship between osteonecrosis of the jaw and bisphosphonate therapy was initially established more than 10 years ago. Since that time our understanding of this disease process has evolved as the direct result of clinical, basic science, and ...
Ruggiero, S. L.
exaly   +2 more sources

Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2020
PURPOSE The aim of this study was to compare primary closure of the extraction socket to application of platelet-rich fibrin (PRF) without subsequent primary closure for the prevention of osteonecrosis of the jaw (ONJ) in patients administered ...
P. Poxleitner, David Steybe, P. Kroneberg, M. Ermer, Gül Merve Yalcin-Ülker, R. Schmelzeisen, P. Voss   +6 more
semanticscholar   +1 more source

Bisphosphonates and Osteonecrosis of the Jaws

Journal of Dental Education, 2008
AbstractBisphosphonates are important drugs that are increasingly prescribed to reduce the morbidity associated with osteoclast‐mediated bone diseases. Shortly after the turn of the century, a variety of case reports described a necrosis of the jaw bone in patients using bisphosphonates.
openaire   +2 more sources

Osteonecrosis of the jaw and bisphosphonates

BMJ, 2010
Low doses for osteoporosis seem to be safe Bisphosphonate associated osteonecrosis of the jaw is defined as exposed bone in the maxillofacial region for more than eight weeks in the absence of radiotherapy but the presence of bisphosphonate use. The condition is diagnosed clinically with exclusion of local malignancy. Other conditions may present in a
openaire   +2 more sources

Osteonecrosis of the jaw in patients treated with denosumab: A multicenter case series.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2018
PURPOSE Osteonecrosis of the jaw has been recently reported in patients receiving denosumab for the treatment of metastatic bone disease and osteoporosis. It is essential to investigate this disease as a new osteonecrosis entity in order to recognize its
Suad Aljohani, R. Gaudin, J. Weiser, M. Tröltzsch, M. Ehrenfeld, G. Kaeppler, R. Smeets, S. Otto   +7 more
semanticscholar   +1 more source

Gingival fibroblasts and medication-related osteonecrosis of the jaw: Results by real-time and wound healing in vitro assays.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2019
OBJECTIVE This study investigated the effects of bisphosphonates and denosumab on human gingival fibroblasts (HGFs) that could influence inflammation, wound healing, and angiogenesis in medication-related osteonecrosis of the jaw (MRONJ).
anna yuan, A. Munz, S. Reinert, S. Hoefert   +3 more
semanticscholar   +1 more source

Drug induced osteonecrosis of the jaw

Cancer Treatment Reviews, 2015
Despite the widespread use of bisphosphonates and their unequivocal efficacy for the treatment of various disease states, osteonecrosis of the jaw remains one of the most feared complications associated with their use. Current evidence, however, suggests that there is also a relationship between occurrence of osteonecrosis of the jaw and use of other ...
Issam S, Hamadeh, Bridget A, Ngwa, Yan, Gong   +2 more
openaire   +2 more sources