Results 91 to 100 of about 61,543 (261)

BMI mediates the association of serum uric acid with bone health: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES)

BMC Musculoskeletal Disorders
Background The associations between serum uric acid and osteoporosis or osteopenia remain controversial, and few studies have explored whether BMI acts as a mediators in the association between the SUA and OP/ osteopenia.
Jiayuan Tu, Xiaoqiao Mo, Xiangda Zhang, Zihao Chen, Lijuan Xi, Chunhui Wu, Xiangchan Zeng, Tian Xie   +7 more
doaj   +1 more source

Osteopenia-osteoporosis discrimination in postmenopausal women by 1H NMR-based metabonomics

PLoS ONE, 2019
This is a report on how 1H NMR-based metabonomics was employed to discriminate osteopenia from osteoporosis in postmenopausal women, identifying the main metabolites associated to the separation between the groups. The Assays were performed using seventy-
T. A. Pontes, A. D. Barbosa, R. D. Silva, M. R. Melo-Júnior, R. O. Silva   +4 more
semanticscholar   +1 more source

De Novo Heterozygous ZFX Frameshift Variant in a Female With an X‐Linked Neurodevelopmental Disorder

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 521-530, February 2026.
ABSTRACT Germline ZFX variants are associated with an X‐linked neurodevelopmental disorder, with 14 males and 16 females reported to date. We describe a 20‐year‐old female with a heterozygous ZFX frameshift variant, p.(Met666Valfs*2), identified by genome sequencing, previously reported in an affected male.
Iftekhar A. Showpnil, Allison Daley, Emily R. Sites, Shayne M. Plourde, Jesse M. Hunter, Dennis W. Bartholomew, April N. Lehman, Daniel C. Koboldt, Rolf W. Stottmann   +8 more
wiley   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway

Journal of Translational Medicine, 2019
Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism.
Hongqi Zhang, Long-jie Wang, Shaohua Liu, Jiong Li, Lige Xiao, Guanteng Yang   +5 more
semanticscholar   +1 more source

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi, Clifton J. Holmes, Chao Cao, Vasavi Shabrish, Aman P. Aher, Karen Shen, Paul K. Commean, Dwight A. Towler, Dominic N. Reeds, Gretchen A. Meyer, Bettina Mittendorfer   +10 more
wiley   +1 more source

Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study

PLoS ONE, 2017
Context Sleep deprivation has detrimental metabolic consequences. Osteopenia and sarcopenia usually occur together and increase risk of fractures and disease.
E. Lucassen, R. de Mutsert, S. le Cessie, N. Appelman‐Dijkstra, F. Rosendaal, D. van Heemst, M. den Heijer, N. Biermasz   +7 more
semanticscholar   +1 more source

Association of Sarcopenia and Lower Bone Density With Positional Vertigo in the Morning: Insights From a Nationwide Survey

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background This study aimed to identify associations of sarcopenia, obesity and low bone mineral density (BMD) with morning positional vertigo (PV) and to examine whether these associations differ according to vestibular function status in a nationally representative sample of Korean adults.
Eun Ji Kim, Eunjin Kwon, Sukyoung Jung, Ji‐Soo Kim, Seong‐Hae Jeong   +4 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

A 50‐year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies

Biological Reviews, Volume 101, Issue 1, Page 437-485, February 2026.
ABSTRACT Sheep and deer calcanei are important models for studying cortical (compact) and trabecular (cancellous) bone adaptation because they are amenable to direct strain measurement (due to lack of surrounding muscles), experience relatively simple/unidirectional bending, exhibit osteon remodelling, and have the most pronounced regional variations ...
John G. Skedros
wiley   +1 more source