Results 1 to 10 of about 99,821 (371)

Clinical and Molecular Implications of Osteopontin in Heart Failure

Current Issues in Molecular Biology, 2022
The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners ...
Argen Mamazhakypov, Meerim Sartmyrzaeva, Akpay Sh. Sarybaev, Ralph Schermuly, Akylbek Sydykov   +4 more
doaj   +2 more sources

Osteopontin‐induced lncRNA HOTAIR expression is involved in osteoarthritis by regulating cell proliferation

BMC Geriatrics, 2021
Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang, Ailijiang Asila, Yingjie Deng, Jun Liao, Zhenfeng Liu, Rui Fang   +5 more
doaj   +2 more sources

Serum osteopontin as a prognostic biomarker in acute exacerbations of chronic obstructive pulmonary disease [PDF]

Frontiers in Immunology
Osteopontin, a phosphorylated glycoprotein, is highly expressed in lung tissues and is elevated in inflammatory diseases. However, its role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains unclear.
Kai-Shu Ma, Li-Na Li, Li-Na Li, Yi-Cheng Ma, Ru-Liu Fan, Gang Chen, Hui Zhao, Hui Zhao, Kai-Xin Qu, Lin Fu, Lin Fu   +10 more
doaj   +2 more sources

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts.
Kate M. Herum, Andreas Romaine, Ariel Wang, Arne Olav Melleby, Mari E. Strand, Julian Pacheco, Bjørn Braathen, Pontus Dunér, Theis Tønnessen, Ida G. Lunde, Ivar Sjaastad, Cord Brakebusch, Andrew D. McCulloch, Maria F. Gomez, Cathrine R. Carlson, Geir Christensen   +15 more
doaj   +2 more sources

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]

, 2018
Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V., Filardi, Tiziana, Lenzi, A., Massoud, R., Morano, S., Nieddu, L., Romagnoli, E., Russo, C., Tavaglione, F., Turinese, Irene   +9 more
core   +3 more sources

In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers [PDF]

BMC Cardiovascular Disorders, 2012
Background Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates
Bishop Emma, Theophilus Eugenia H, Fearon Ian M   +2 more
doaj   +2 more sources

Immunohistochemical Staining Properties of Osteopontin and Ki-67 in Feline Meningiomas

Animals
The high recurrence rate of feline meningioma despite the generally benign histomorphology warrants additional markers of clinical aggressiveness. The Ki-67 index is commonly used as prognostic marker for meningioma recurrence in people. Osteopontin (OPN)
Gabriele Gradner, Janina Janssen, Anna Oevermann, Alexander Tichy, Stefan Kummer, Stefanie Burger, Ingrid Walter   +6 more
doaj   +2 more sources

Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. [PDF]

PLoS Medicine, 2005
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung.
Annie Pardo, Kevin Gibson, José Cisneros, Thomas J Richards, Yinke Yang, Carina Becerril, Samueal Yousem, Iliana Herrera, Victor Ruiz, Moisés Selman, Naftali Kaminski   +10 more
doaj   +2 more sources

Assessing the Level and Diagnostic Accuracy of Osteopontin and Oral Health Status in Periodontitis Patients with/without Type-2 Diabetes Mellitus

Brazilian Dental Science, 2022
Objective: Periodontitis is a multifactorial inflammatory disease usually terminated with tooth loss when untreated. Type-2 diabetes mellitus (T2DM) have shown to exacerbate periodontitis.
Ahmed Makki A. Al-Qarakhli, Firas B. Al-Taweel, Lubaba A. Abdul Ameer, Saif S. Saliem, Ali A. Abdulkareem   +4 more
doaj   +1 more source

Osteopontin Is Associated with Multiple Sclerosis Relapses

Biomedicines, 2023
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease ...
Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Ennio Iezzi, Giovanni Galifi, Fortunata Carbone, Teresa Micillo, Ettore Dolcetti, Federica Azzolini, Antonio Bruno, Angela Borrelli, Georgia Mandolesi, Valentina Rovella, Marianna Storto, Annamaria Finardi, Roberto Furlan, Diego Centonze, Giuseppe Matarese   +17 more
doaj   +1 more source