Results 11 to 20 of about 99,821 (371)

Osteopontin in Cardiovascular Diseases [PDF]

Biomolecules, 2021
Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally.
K. Shirakawa, M. Sano
semanticscholar   +4 more sources

Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Cells, 2019
The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function.
Anne-Sophie Lamort, Ioanna Giopanou, Ioannis Psallidas, Georgios T. Stathopoulos   +3 more
doaj   +2 more sources

Osteopontin in Cancer: Mechanisms and Therapeutic Targets

International Journal of Translational Medicine, 2022
Despite significant advances in the understanding of cancer biology, cancer is still a leading cause of death worldwide. Expression of the tumor microenvironment component, osteopontin, in tumor tissues, plasma, and serum, has been shown to be associated
Yoshinobu Kariya, Yukiko Kariya
doaj   +2 more sources

Osteopontin is a therapeutic target that drives breast cancer recurrence

Nature Communications
Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes.
Yu Gu, Tarek Taifour, Tung Bui, Dongmei Zuo, Alain Pacis, Alexandre Poirier, Sherif Attalla, Anne-Marie Fortier, Virginie Sanguin-Gendreau, Tien-Chi Pan, Vasilios Papavasiliou, Nancy U. Lin, Melissa E. Hughes, Kalie Smith, Morag Park, Michel L. Tremblay, Lewis A. Chodosh, Rinath Jeselsohn, William J. Muller   +18 more
doaj   +2 more sources

The Yin-Yang of osteopontin in nervous system diseases: damage versus repair

Neural Regeneration Research, 2021
Osteopontin is a broadly expressed pleiotropic protein, and is attracting increased attention because of its role in the pathophysiology of several inflammatory, degenerative, autoimmune, and oncologic diseases.
Giuseppe Cappellano, Domizia Vecchio, Luca Magistrelli, Nausicaa Clemente, Davide Raineri, Camilla Barbero Mazzucca, Eleonora Virgilio, Umberto Dianzani, Annalisa Chiocchetti, Cristoforo Comi   +9 more
doaj   +2 more sources

Osteopontin in Pulmonary Hypertension

Biomedicines, 2023
Pulmonary hypertension (PH) is a pathological condition with multifactorial etiology, which is characterized by elevated pulmonary arterial pressure and pulmonary vascular remodeling.
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov   +4 more
doaj   +4 more sources

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin‐3hiCD206+ macrophages is ...
Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Atsushi Anzai, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Seien Ko, Shinichi Goto, Genki Ichihara, Keiichi Fukuda, Tohru Minamino, Motoaki Sano   +13 more
doaj   +2 more sources

Osteopontin binds ICOSL promoting tumor metastasis [PDF]

Communications Biology, 2020
ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the
Davide Raineri, Chiara Dianzani, Giuseppe Cappellano, Federica Maione, Gianluca Baldanzi, Ilaria Iacobucci, Nausicaa Clemente, Giulia Baldone, Elena Boggio, Casimiro Luca Gigliotti, Renzo Boldorini, José María Rojo, Maria Monti, Leila Birolo, Umberto Dianzani, Annalisa Chiocchetti   +15 more
openalex   +2 more sources

Osteopontin [PDF]

Springer Reference Medizin, 2019
S. Holdenrieder
semanticscholar   +2 more sources

Mesothelin and osteopontin [PDF]

European Respiratory Journal, 2013
From the Authors: We would like to thank Gunnar Hillerdal for his interest in our article 1 and for giving us the opportunity to make some comments regarding multimodality therapy and early stage disease. Sugarbaker et al . 2 reported a groundbreaking result in 1999: patients with early stage malignant pleural mesothelioma (MPM) had a 5-year ...
Pantazopoulos, I., Xanthos, T., Boura, P., Syrigos, K.   +3 more
openaire   +6 more sources