Results 21 to 30 of about 99,821 (371)
MACROPHAGE-DERIVED OSTEOPONTIN (SPP1) PROTECTS FROM NON-ALCOHOLIC STEATOHEPATITIS.
Gastroenterology, 2023 BACKGROUND & AIMS Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning degeneration and fibrosis, all of which increase the risk of progression to end-stage liver disease. Osteopontin (OPN, SPP1)
Hui-Jing Han +11 more
semanticscholar +1 more source
Osteopontin as a Biomarker in Chronic Kidney Disease
Biomedicines, 2023 Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing.
Satyesh K Sinha +4 more
semanticscholar +1 more source
Milk Osteopontin and Human Health
Nutrients, 2023 Osteopontin (OPN) is a multifunctional protein found in all vertebrates. OPN is expressed in many different cell types, and is consequently found in most tissues and physiological secretions.
E. S. Sørensen, B. Christensen
semanticscholar +1 more source
Osteopontin, a bridge links osteoarthritis and osteoporosis
Frontiers in Endocrinology, 2022 Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints.
Ruiping Bai, Yu-Sheng Li, Fangjie Zhang
semanticscholar +1 more source
Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
Nature Communications, 2022 Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone metabolism are not well understood. Here, we report that macrophages in
Bingyang Dai +20 more
semanticscholar +1 more source
Acta Neuropathologica, 2022 Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke.
Daniel Spitzer +21 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 Ovarian cancer is the leading cause of gynecological malignancy-related deaths, due to its widespread intraperitoneal metastases and acquired chemoresistance.
Jin Qian +12 more
semanticscholar +1 more source
Osteopontin in Bone Metabolism and Bone Diseases
Medical Science Monitor, 2020 Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone
Jinyan Si +5 more
semanticscholar +1 more source
Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface
Frontiers in Cell and Developmental Biology, 2023 Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines +4 more
doaj +1 more source
Genetic modifiers of Duchenne muscular dystrophy and dilated cardiomyopathy [PDF]
, 2015 OBJECTIVE: Dilated cardiomyopathy (DCM) is a major complication and leading cause of death in Duchenne muscular dystrophy (DMD). DCM onset is variable, suggesting modifier effects of genetic or environmental factors.
Angelini, Corrado +22 more
core +8 more sources