Results 31 to 40 of about 99,821 (371)
Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer
Archives of Medical Science, 2020 Introduction Triple-negative breast cancer (TNBC) is associated with lack of expression of estrogen and progesterone receptors and HER2 and is the subgroup of breast cancers with the worst prognosis.
Magdalena Niedolistek +11 more
doaj +1 more source
Scientific Reports, 2022 Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain barrier (BBB).
Daniel Spitzer +11 more
doaj +1 more source
Osteopontin Takes Center Stage in Chronic Liver Disease
Hepatology, 2020 Osteopontin (OPN) was first identified in 1986. The prefix osteo‐ means bone; however, OPN is expressed in other tissues, including liver. The suffix ‐pontin means bridge and denotes the role of OPN as a link protein within the extracellular matrix ...
Zhuolun Song +7 more
semanticscholar +1 more source
Disease Models & Mechanisms, 2013 SUMMARY Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests ...
Kitipong Uaesoontrachoon +3 more
doaj +1 more source
Separation Options for Phosphorylated Osteopontin from Transgenic Microalgae Chlamydomonas reinhardtii. [PDF]
, 2018 Correct folding and post-translational modifications are vital for therapeutic proteins to elicit their biological functions. Osteopontin (OPN), a bone regenerative protein present in a range of mammalian cells, is an acidic phosphoprotein with multiple ...
Guo, Shengchun +5 more
core +2 more sources
Osteopontin in chronic obstructive pulmonary disease: Smokers and ex-smokers
Egyptian Journal of Chest Disease and Tuberculosis, 2015 Background: COPD is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between osteopontin, smoking and COPD needs to be clarified.
Ahmed A Ali +4 more
doaj +1 more source
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice. [PDF]
PLoS ONE, 2010 Metastasis to the lung may be the final step in the breast cancer-related morbidity. Conventional therapies such as chemotherapy and surgery are somewhat successful, however, metastasis-related breast cancer morbidity remains high. Thus, a novel approach
Kyeong-Nam Yu +17 more
doaj +1 more source
Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation
Cancers, 2020 Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade (ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment. Durable efficacy has been achieved in many types of human cancers.
Hannah R. Moorman +5 more
semanticscholar +1 more source
Journal of Hematology & Oncology, 2011 The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis.
Kotsis Vasileios +7 more
doaj +1 more source
Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]
, 2016 In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R +7 more
core +2 more sources