Results 61 to 70 of about 99,821 (371)

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection

EMBO Molecular Medicine, 2021
Graphical Abstract This study independently confirms increased levels of osteopontin in COVID‐19 patients but also suggests that osteopontin cannot be used as a biomarker of SARS‐CoV‐2 infection, as elevated levels of circulating osteopontin are found in
Giuseppe Cappellano, Hugo Abreu, Davide Raineri, Lorenza Scotti, Luigi Castello, Rosanna Vaschetto, Annalisa Chiocchetti   +6 more
doaj   +1 more source

Osteopontin Activation and Microcalcification in Venous Grafts Can Be Modulated by Dexamethasone

Cells, 2023
Background: Osteopontin has been implicated in vascular calcification formation and vein graft intimal hyperplasia, and its expression can be triggered by pro-inflammatory activation of cells.
Liam W. McQueen, Shameem S. Ladak, Georgia R. Layton, Kerry Wadey, Sarah J. George, Gianni D. Angelini, Gavin J. Murphy, Mustafa Zakkar   +7 more
doaj   +1 more source

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

Mesothelin and osteopontin as diagnostic and prognostic markers of malignant pleural mesothelioma in Egyptian patients undergoing pleurodesis

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Purpose: In malignant pleural mesothelioma (MPM), early assessment of disease status is important. We evaluated the role of mesothelin and osteopontin biomarkers in distinguishing MPM from benign pleural disease. We also, evaluated whether mesothelin and
Fawzy M. Amany, Nagat Ali Mohamed, Reda El-Ghamry, Alaa Brik, Abdel Maged Salem, Amira Shoukry, Azza El-Sebaey   +6 more
doaj   +1 more source

Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype [PDF]

, 2010
Background Recent studies have indicated the presence of multipotent mesenchymal stromal cells (MSCs) in human lung diseases. Excess airway smooth muscle, myofibroblasts and activated fibroblasts have each been noted in asthma, suggesting that ...
Adam M Goldsmith, Amy E Baek, Antonia P Popova, Bentley, J Kelley, J Kelley Bentley, Jing Lei, Marc B Hershenson, Marisa J Linn, Paul D Bozyk   +8 more
core   +6 more sources

Serum osteopontin can improve papillary thyroid cancer risk assessment of Bethesda III thyroid nodules: a preliminary study

Endocrine Oncology, 2023
Objective: Thyroid cancer can be detected in 5–10% of patients with thyroid nodules. Management may be a challenge if fine-needle aspiration biopsy yields Bethesda III findings. Most of these cases undergo surgery and are ultimately found benign. Our aim
T U Kars, M Kulaksızoğlu, İ Kılınç
doaj   +1 more source

Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]

, 2010
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core   +1 more source

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the αXβ2 Integrin [PDF]

The Journal of Immunology, 2009
Abstract Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process ...
Schack, Lotte, Stapulionis, Romualdas, Christensen, Brian, Kofod-Olsen, Emil, Sørensen, Uffe B. Skov, Vorup-Jensen, Thomas, Sørensen, Esben S, Höllsberg, Per   +7 more
openaire   +3 more sources

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source